Silver nanoparticle-induced alteration of mitochondrial and ER homeostasis affects human breast cancer cell fate

Dey, Smita; Fageria, Leena; Sharma, Ankita; Mukherjee, Sudeshna; Pande, Surojit; Chowdhury, Rajdeep; Chowdhury, Shibasish

doi:10.1016/j.toxrep.2022.10.017

Cited by 18 publications

(7 citation statements)

References 43 publications

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“…Activation of this signaling pathway resulted in an increase in cytoplasmic calcium levels and activation of caspase -12 [ 109 ]. Similar effects were also reported on the human breast cancer cells MDA-MB-231 and MCF-7 [ 110 , 111 ]. In addition, AgNPs also activate the IRE1 (endoribonuclease) branch of the UPR, which results in the cytosolic splicing of XBP1, a transcription factor that can subsequently translocate to the nucleus.…”

Section: The Potential Of Agnps In Nano-oncologysupporting

confidence: 82%

The Role of Silver Nanoparticles in the Diagnosis and Treatment of Cancer: Are There Any Perspectives for the Future?

Takáč

Michalková

Čižmáriková

et al. 2023

Life

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Cancer is a fatal disease with a complex pathophysiology. Lack of specificity and cytotoxicity, as well as the multidrug resistance of traditional cancer chemotherapy, are the most common limitations that often cause treatment failure. Thus, in recent years, significant efforts have concentrated on the development of a modernistic field called nano-oncology, which provides the possibility of using nanoparticles (NPs) with the aim to detect, target, and treat cancer diseases. In comparison with conventional anticancer strategies, NPs provide a targeted approach, preventing undesirable side effects. What is more, nanoparticle-based drug delivery systems have shown good pharmacokinetics and precise targeting, as well as reduced multidrug resistance. It has been documented that, in cancer cells, NPs promote reactive oxygen species (ROS) production, induce cell cycle arrest and apoptosis, activate ER (endoplasmic reticulum) stress, modulate various signaling pathways, etc. Furthermore, their ability to inhibit tumor growth in vivo has also been documented. In this paper, we have reviewed the role of silver NPs (AgNPs) in cancer nanomedicine, discussing numerous mechanisms by which they render anticancer properties under both in vitro and in vivo conditions, as well as their potential in the diagnosis of cancer.

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Section: The Potential Of Agnps In Nano-oncologysupporting

confidence: 82%

The Role of Silver Nanoparticles in the Diagnosis and Treatment of Cancer: Are There Any Perspectives for the Future?

Takáč

Michalková

Čižmáriková

et al. 2023

Life

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“…It was also shown that AgNPs trigger apoptosis by increasing the amount of ROS and then changing the mitochondrial membrane potential of cells. In accordance with these results, the apoptosis-inducing ability of AgNPs in cancer cells was confirmed by recent reports [ 3 , 37 ].…”

Section: Discussionsupporting

confidence: 91%

“…These ROS molecules might cause oxidative stress within cancer cells, leading to DNA damage, protein denaturation, and ultimately cell death. Additionally, AgNPs have been shown to disrupt the mitochondrial function of cancer cells, further impairing their survival and proliferation [ 1 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Anticancer Action of Silver Nanoparticles in SKBR3 Breast Cancer Cells through Promotion of Oxidative Stress and Apoptosis

Vahabirad,

Daei,

Abbasalipourkabir

et al. 2024

BioMed Research International

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Silver nanoparticles (AgNPs) are known as one of the highly utilized NPs owing to their unique characteristics in the field of cancer research. The goal of this research was to explore the oxidative stress, apoptosis, and angiogenesis in SKBR3 breast cancer cells after exposure to AgNPs. The survival rate of SKBR3 cancer cells and MCF-10A normal breast cells was assessed under the effects of different concentrations (0, 32, 64, 128, and 250 μg/ml) by MTT method. The oxidative condition was assessed by measuring reactive oxygen species (ROS) production, total oxidant status (TOS), total antioxidant capacity (TAC), malondialdehyde (MDA), and antioxidant enzyme activity (CAT, GPx, and CAT) using colorimetric-based kits. Flow cytometry and Hoechst 33258 staining were performed to investigate the induction of apoptosis. Furthermore, the expression of Bcl-2-associated X protein (Bax), B-cell lymphoma 2 (Bcl-2), and caspase 3 and 7 activity was measured. The cell migration and vascular endothelial growth factor-A (VEGF-A) gene expression, protein kinase B (AKT), phosphatidylinositol 3-kinase (PI3K) were also studied. The MTT results indicated that AgNPs inhibit the SKBR3 cells’ viability in a concentration-dependent way. Besides, AgNPs markedly induced oxidative stress via increasing TOS content, MDA production, reduction of TAC, and regulation of antioxidant enzyme level. Additionally, AgNPs promoted apoptosis as revealed by an enhancement in Bax/Bcl-2 expression ratio. Findings also indicated that AgNPs suppress the expression of genes (VEGF-A, AKT, and PI3K) involved in angiogenesis. Altogether, our data revealed that AgNPs initiate oxidative stress and apoptosis in SKBR3 breast cancer cells, dose dependently.

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“…the killing of the breast cancer and neuroblastoma cells. [89,90] In the family of metallic nanoparticles, quantum dots gained huge attention in last half a century due to their applications in bioimaging and therapeutic field. Interestingly, cadmium telluride quantum dots (CdTe QDs) were found to be rapidly localized into the ER of the HUVEC cells through endocytosis and induced significant ER stress by upregulating the ER stress marker GRP78/GRP94, PERK and eIF2α.…”

Section: Reviewmentioning

confidence: 99%

Biomaterials for Targeting Endoplasmic Reticulum in Cancer

Mishra,

Sengupta,

Basu

2024

Chemistry An Asian Journal

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Endoplasmic reticulum (ER) is one of the most important sub‐cellular organelles which controls myriads of biological functions including protein biosynthesis with proper functional folded form, protein misfolding, protein transport into Golgi body for secretion, Ca2+ homeostasis and so on. Subsequently, dysregulation in ER function leads to ER stress followed by disease pathology like cancer. Hence, targeting ER in the cancer cells emerged as one of the futuristic strategies for cancer treatment. However, the major challenge is to selectively and specifically target ER in the sub‐cellular milieu in the cancer tissues, due to the lack of ER targeting chemical moieties to recognize the ER markers. To address this, in last decade, numerous biomaterials were explored to selectively impair and image ER in cancer cells to induce ER stress. This review outlines those biomaterials which consists of carbon and silicon materials, lipid nanoparticles (liposomes and micelles), supramolecular self‐assembled nanostructures, cell membrane coated nanoparticles and metallic nanoparticles. Moreover, we also discussed the challenges and possible solutions of this promising field to usher the readers towards next‐generation ER targeted cancer therapy.

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Silver nanoparticle-induced alteration of mitochondrial and ER homeostasis affects human breast cancer cell fate

Cited by 18 publications

References 43 publications

The Role of Silver Nanoparticles in the Diagnosis and Treatment of Cancer: Are There Any Perspectives for the Future?

The Role of Silver Nanoparticles in the Diagnosis and Treatment of Cancer: Are There Any Perspectives for the Future?

Anticancer Action of Silver Nanoparticles in SKBR3 Breast Cancer Cells through Promotion of Oxidative Stress and Apoptosis

Biomaterials for Targeting Endoplasmic Reticulum in Cancer

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