Silver nanoparticle–induced nephrotoxicity in Clarias gariepinus: physio-histological biomarkers

Mahmoud, Usama M.; Mekkawy, Imam A.; Naguib, Mervat; Sayed, Alaa El‐Din H.

doi:10.1007/s10695-019-00686-7

Cited by 24 publications

(14 citation statements)

References 39 publications

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“…The results of the current study indicated that the level of GSH remains at a normal range in C. carpio when treated with green AgNPs as compared to Ch‐AgNPs and Ag salt. As the green AgNPs contain some ligands and Phyto groups which reduce the toxicity of the AgNPs (Mahmoud, Mekkawy, Naguib, & Sayed, 2019). There was an increment in the level of GSH was found in the green AgNPs when compared with the Ag salt (Naguib, Mahmoud, Mekkawy, & Sayed, 2020).…”

Section: Discussionmentioning

confidence: 99%

Comparative evaluation of the toxicological effect of silver salt (AgNO₃) and silver nanoparticles on Cyprinus carpio synthesized by chemicals and marine algae using scanning electron microscopy

Liaqat

Hanif

Bahadur

et al. 2021

Microscopy Res & Technique

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The widespread use of silver nanoparticles (AgNPs) results in the unintentional release into the water body. Therefore, understanding of the potentially harmful impacts of AgNPs and Ag‐salt on aquatic animals is a need of time. This study was design to analyze the oxidative stress and histopathological damages in Cyprinus carpio. The synthesis of AgNPs from Halymenia porphyraeformis and by reduction of chemical was done. Nanoparticles were characterized with UV–Visible spectroscopy, SEM, XRD, and FTIR analysis. The comparative toxicological effect of chemically synthesized silver nanoparticles (Ch‐AgNPs), green silver nanoparticles (Gr‐AgNPs), and Ag‐salt on C. carpio was analyzed. For oxidative stress analysis, different tests Lipid peroxidation (LPO), catalase, glutathione reduction (GST), and glutathione S‐transferase (GST) were performed. The highest LPO 245.168 ± 0.034 was recorded in Ch‐AgNPs‐treated gills and the lowest 56.4532 ± 0.02 was found in Gr‐AgNPs‐treated liver. Maximum GSH 56.4065 ± 0.13 was observed in Gr‐AgNPs liver and minimum 40.781 ± 0.54 was recorded in Ag‐salt gills. The maximum quantity of catalase 68.0162 ± 0.09 was noted in the Ag‐salt‐treated liver and the minimum was calculated 17.3665 ± 0.01 in the liver of Ch‐AgNPs and highest values of GST 765.829 ± 0.11 were recorded in gills of Gr‐AgNPs and lowest 633.08 ± 0.26 in the liver of Ch‐AgNPs‐treated fish. In conclusion, maximum destruction was found in the gills and liver of the fish treated with chemical and green AgNPs followed by Ag‐salt as compared to control. The adverse effects of AgNPs and Ag‐salt were probably related to the oxidative stress in the fish that lead to histopathological damage of its vital organs.

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Section: Discussionmentioning

confidence: 99%

Comparative evaluation of the toxicological effect of silver salt (AgNO₃) and silver nanoparticles on Cyprinus carpio synthesized by chemicals and marine algae using scanning electron microscopy

Liaqat

Hanif

Bahadur

et al. 2021

Microscopy Res & Technique

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“…The nephrotoxicity of various AgNP-treated organisms was also examined. In fish, for example, it has been demonstrated that AgNPs could be trapped or filtered through the renal system [131]. However, a comparison of silver concentrations in the urine and feces of rats receiving AgNP administration revealed that the amount of silver eliminated through the urinary system is significantly less than those eliminated by fecal excretion, suggesting biliary secretion of AgNPs over renal filtering [132].…”

Section: Applicability Of Agnps As Anti-cancer Agents 41 Safety Issues: Toxicology On Healthy Tissuesmentioning

confidence: 99%

Cancer Therapy by Silver Nanoparticles: Fiction or Reality?

Kovács

Igaz

Gopisetty

et al. 2022

IJMS

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As an emerging new class, metal nanoparticles and especially silver nanoparticles hold great potential in the field of cancer biology. Due to cancer-specific targeting, the consequently attenuated side-effects and the massive anti-cancer features render nanoparticle therapeutics desirable platforms for clinically relevant drug development. In this review, we highlight those characteristics of silver nanoparticle-based therapeutic concepts that are unique, exploitable, and achievable, as well as those that represent the critical hurdle in their advancement to clinical utilization. The collection of findings presented here will describe the features that distinguish silver nanoparticles from other anti-cancer agents and display the realistic opportunities and implications in oncotherapeutic innovations to find out whether cancer therapy by silver nanoparticles is fiction or reality.

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“…Plasma creatinine and uric acid levels are indicators of the kidney function (Mahmoud et al, 2019), and it has been reported that anaesthesia may cause elevation in these blood parameters, which may be an indication of kidney dysfunction (Souza et al, 2017). However, the present results indicate that cineole at the tested concentrations has no negative effects on the kidney function in Caspian trout.…”

Section: Discussionmentioning

confidence: 99%

Effects of anaesthesia with 1,8‐cineole on haematological and plasma stress responses in Caspian trout, Salmo caspius , subadults

Mirghaed

Hoseini

Aydın

et al. 2021

Aquaculture Research

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In aquaculture practices, fish are often exposed to several stressors such as handling, weighing, tagging, artificial spawning, blood sampling, vaccination, measurement and transportation (Aydın & Orhan, 2021;Tarkhani et al., 2017). Immobilization of the fish in all these practices not only helps to reduce stress but also prevents physical damage (da Silva et al., 2021). Therefore, anaesthetic agents are important tools in aquaculture practices, and several drugs are available for fish anaesthesia, including tricaine methanesulfonate (which is the only anaesthetic approved in the United States and Canada) and clove oil (the most widely used herbal anaesthetic), among

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Silver nanoparticle–induced nephrotoxicity in Clarias gariepinus: physio-histological biomarkers

Cited by 24 publications

References 39 publications

Comparative evaluation of the toxicological effect of silver salt (AgNO₃) and silver nanoparticles on Cyprinus carpio synthesized by chemicals and marine algae using scanning electron microscopy

Comparative evaluation of the toxicological effect of silver salt (AgNO₃) and silver nanoparticles on Cyprinus carpio synthesized by chemicals and marine algae using scanning electron microscopy

Cancer Therapy by Silver Nanoparticles: Fiction or Reality?

Effects of anaesthesia with 1,8‐cineole on haematological and plasma stress responses in Caspian trout, Salmo caspius , subadults

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Silver nanoparticle–induced nephrotoxicity in Clarias gariepinus: physio-histological biomarkers

Cited by 24 publications

References 39 publications

Comparative evaluation of the toxicological effect of silver salt (AgNO3) and silver nanoparticles on Cyprinus carpio synthesized by chemicals and marine algae using scanning electron microscopy

Comparative evaluation of the toxicological effect of silver salt (AgNO3) and silver nanoparticles on Cyprinus carpio synthesized by chemicals and marine algae using scanning electron microscopy

Cancer Therapy by Silver Nanoparticles: Fiction or Reality?

Effects of anaesthesia with 1,8‐cineole on haematological and plasma stress responses in Caspian trout, Salmo caspius , subadults

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Product

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Comparative evaluation of the toxicological effect of silver salt (AgNO₃) and silver nanoparticles on Cyprinus carpio synthesized by chemicals and marine algae using scanning electron microscopy

Comparative evaluation of the toxicological effect of silver salt (AgNO₃) and silver nanoparticles on Cyprinus carpio synthesized by chemicals and marine algae using scanning electron microscopy