Silver nanoparticles: an upcoming therapeutic agent for the resistant Candida infections

Perween, Nusrat; Khan, Harris M; Fatima, Nazish

doi:10.15406/jmen.2019.07.00240

Cited by 14 publications

(17 citation statements)

References 31 publications

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“…Moreover, all C. auris strains tested here displayed susceptibility to AgNPs, irrespective of their growth characteristics, susceptibility profiles against conventional antifungal, or their geographical origin (clade). This has been observed in other microorganisms, including other Candida species, where the drug-resistant strains and drug-sensitive strains from the same species display a similar susceptibility (MIC value) to AgNPs [23,24]. Additionally, our results suggest that AgNPs antimicrobial performance is better than the main antifungals on all the tested C. auris CDC AR strains, according to their antifungal susceptibility profile reported by the CDC [25].…”

Section: Resultssupporting

confidence: 81%

Silver nanoantibiotics display strong antifungal activity against the emergent multidrug-resistant yeastCandida aurisunder both planktonic and biofilm growing conditions

Vázquez-Muñoz

López

López-Ribot

2020

Preprint

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Candida auris is an emergent multidrug-resistant pathogenic yeast with an unprecedented ability for a fungal organism to easily spread between patients in clinical settings, leading to major outbreaks in healthcare facilities. The formation of biofilms by C. auris contributes to infection and its environmental persistence. Most antifungals and sanitizing procedures are not effective against C. auris, but antimicrobial nanomaterials could represent a viable alternative to combat the infections caused by this emerging pathogen. We have previously described an easy and inexpensive method to synthesize silver nanoparticles (AgNPs) in non-specialized laboratories. Here we have assessed the antimicrobial activity of the resulting AgNPs on C. auris planktonic and biofilm growth phases. AgNPs displayed a strong antimicrobial activity against all the stages of all C. auris strains tested, representative of four different clades. Under planktonic conditions, MIC values of AgNPs against the different strains were <0.5 μg mL-1; whereas calculated IC50 values for inhibition of biofilms formation were < 2 μg mL-1 for all but one of the C. auris strains tested. AgNPs were also active against preformed biofilms formed by all different C. auris strains, with IC50 values ranging from 1.2 to 6.2 μg mL-1. Overall, our results indicate potent activity of AgNPs against strains of C. auris, both under planktonic and biofilm growing conditions, and indicate that AgNPs may contribute to the control of infections caused by this emerging nosocomial threat.

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Section: Resultssupporting

confidence: 81%

Silver nanoantibiotics display strong antifungal activity against the emergent multidrug-resistant yeastCandida aurisunder both planktonic and biofilm growing conditions

Vázquez-Muñoz

López

López-Ribot

2020

Preprint

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“…The antimicrobial effect of Pa-AgNPs against C. albicans was strong compared to the crude W.indica leaf extracts reported by Koma et al [17]. The results obtained justi es potent microbicidal activity of Pa-AgNPs that were also relevant with the reported literatures [45][46][47] of AgNPs. Presence of charge, size, shape, concentration, dissolution rate, species type, tolerance and time of exposure may attribute to the antimicrobial property of AgNPs [21,[48][49][50].…”

Section: Antimicrobial Screening Of Pa-agnpssupporting

confidence: 80%

Characterization, Antimicrobial and Antioxidant evaluation of biofabricated silver nanoparticles from endophytic Pantoea anthophila

Nirmala

Sridevi

2021

Preprint

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Endophyte mediated nanoparticles fabrication was emerging as a new frontier in nanomedicines that produce high biocompatible and functionalized silver nanoparticles. In this study, silver nanoparticles were successfully biosynthesized from the extracellular extract of endophytic bacterium Pantoea anthophila isolated from the stem of Waltheria indica for the first time. The synthesised nanoparticles were characterized by UV-Visible and Fourier Transform Infra-Red spectroscopy. The structural analysis is done by X-ray diffraction and the stability was studied by dynamic light scattering and particle size analyser. The size and shape were observed by Transmission Electron Microscope, Scanning Electron Microscope and Energy Dispersive X-Ray spectrum. Further, the nanoparticles were evaluated for antimicrobial and antioxidant properties. Synthesized nanoparticle showed a strong absorption band in the UV-Visible range at 410 nm. The average particle size was found to be 16.8 nm with spherical shaped, crystalline nature. Good zones of inhibition at various ranges were detected against a broad range of human pathogenic bacteria and fungi. A strong free radical scavenging activity of silver nanoparticles with IC50 values 30.75, 19.47, 34.59, 41.12, 27.24, 28.16, 36.21 µg/ml was obtained that was comparable to the reference. The study suggests that the silver nanoparticles can be biosynthesised from endophytic P. anthophila metabolites with significant therapeutic potential. With proper validation, the biosynthesised silver nanoparticles can be developed as a promising antiviral and anticancer drug candidate.

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“…Moreover, the aggregating phenotype may be associated with their drug susceptibility (Szekely et al, 2019). This has been observed in other microorganisms, including other Candida species, where the drug-resistant strains and drug-sensitive strains from the same species display a similar susceptibility (MIC value) to AgNPs (Romero-Urbina et al, 2015;Perween et al, 2019). Additionally, our results suggest that AgNPs antimicrobial performance is better than the main antifungals on all the tested C. auris CDC AR strains, according to their antifungal susceptibility profile reported by the CDC (CDC, 2020).…”

Section: Discussionmentioning

confidence: 83%

Silver Nanoantibiotics Display Strong Antifungal Activity Against the Emergent Multidrug-Resistant Yeast Candida auris Under Both Planktonic and Biofilm Growing Conditions

2020

View full text Add to dashboard Cite

Candida auris is an emergent multidrug-resistant pathogenic yeast with an unprecedented ability for a fungal organism to easily spread between patients in clinical settings, leading to major outbreaks in healthcare facilities. The formation of biofilms by C. auris contributes to infection and its environmental persistence. Most antifungals and sanitizing procedures are not effective against C. auris, but antimicrobial nanomaterials could represent a viable alternative to combat the infections caused by this emerging pathogen. We have previously described an easy and inexpensive method to synthesize silver nanoparticles (AgNPs) in non-specialized laboratories. Here, we have assessed the antimicrobial activity of the resulting AgNPs on C. auris planktonic and biofilm growth phases. AgNPs displayed a strong antimicrobial activity against all the stages of all C. auris strains tested, representative of four different clades. Under planktonic conditions, minimal inhibitory concentration (MIC) values of AgNPs against the different strains were <0.5 μg ml −1 ; whereas calculated IC 50 values for inhibition of biofilms formation were <2 μg ml −1 for all, but one of the C. auris strains tested. AgNPs were also active against preformed biofilms formed by all different C. auris strains, with IC 50 values ranging from 1.2 to 6.2 μg ml −1. Overall, our results indicate potent activity of AgNPs against strains of C. auris, both under planktonic and biofilm growing conditions, and indicate that AgNPs may contribute to the control of infections caused by this emerging nosocomial threat.

show abstract

Silver nanoparticles: an upcoming therapeutic agent for the resistant Candida infections

Cited by 14 publications

References 31 publications

Silver nanoantibiotics display strong antifungal activity against the emergent multidrug-resistant yeastCandida aurisunder both planktonic and biofilm growing conditions

Silver nanoantibiotics display strong antifungal activity against the emergent multidrug-resistant yeastCandida aurisunder both planktonic and biofilm growing conditions

Characterization, Antimicrobial and Antioxidant evaluation of biofabricated silver nanoparticles from endophytic Pantoea anthophila

Silver Nanoantibiotics Display Strong Antifungal Activity Against the Emergent Multidrug-Resistant Yeast Candida auris Under Both Planktonic and Biofilm Growing Conditions

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