Silver Nanoparticles Incorporated in pH-Sensitive Nanocomposite Hydrogels Based on Carboxymethyl Chitosan-Poly (Vinyl Alcohol) for Use in a Drug Delivery System

Gholamali, Iman; Asnaashariisfahani, Manzarbanou; Alipour, Eskandar

doi:10.1007/s40883-019-00120-7

Cited by 80 publications

(44 citation statements)

References 46 publications

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“…The crosslinker not only create the sharping of structures, but also helps in gathering the structure by making colony because of coagulation of structures the complex viscosity, thermal stability, and processability behavior are increased which are explained in later part of the investigation. Our findings are in agreement with the previous work obtained from Ag NPs are formed in situ within the swollen CMCh‐PVA hydrogel to be used as a drug delivery system 63 . Similar SEM results are observed in work of Mascharak et al 64 …”

Section: Resultssupporting

confidence: 93%

“…Schematic illustration of ornidazole drug loaded and release profile of PPO/PEO‐C@Ag hybrid nanocomposite hydrogel is represented in Scheme 2. Our findings are in accordance with the previous work 63 . Those results are in accordance with the reported results during the study of novel magnetically responsive hydrogel are synthesized by radical polymerization of carboxymethyl cellulose (CMC) on acryl amide (Am) using N , N′ ‐methylene bis acrylamide (MBA) as a crosslinking agent as colon targeted drug delivery 81…”

Section: Resultssupporting

confidence: 93%

“…Our findings are in agreement with the previous work obtained from Ag NPs are formed in situ within the swollen CMCh-PVA hydrogel to be used as a drug delivery system. 63 Similar SEM results are observed in work of Mascharak et al 64…”

Section: Morphological Analysissupporting

confidence: 84%

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Polypropylene oxide/polyethylene oxide‐cellulose hybrid nanocomposite hydrogels as drug delivery vehicle

Prusty

Swain

2020

J of Applied Polymer Sci

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This article deals with the synthesis of hybrid nanocomposite hydrogels through the combination of cellulose (C), polypropylene oxide/poly ethylene oxide (PPO/PEO), and silver nanoparticles (AgNPs) by in situ polymerization technique for the in vitro release of ornidazole drugs. The structure of the resulted materials is identified using SEM, XRD, FTIR, XPS, and TGA spectroscopic techniques. The resulting structure, morphology, thermo responsive property, water retention, and swelling behavior of hydrogels are investigated. The rheological measurement is studied to establish the enhancement of the viscoelasticity and stiffness of hydrogels. The antibacterial activity of the biodegradable silver hybrid nanocomposite hydrogel is investigated by inhibition zone method against gram positive and negative bacteria. Maximum drug release of 96.4% is recorded at 7.4 pH in 5 h. The biocompatibility and cytotoxicity of the hybrid nanocomposite hydrogel are verified using mouse fibroblast cell line L-929 (ATCC CCL-1) cells for their possible use as controlled drug delivery vehicles. The nontoxic nature makes the materials more biocompatible and suitable to apply in the biological systems. Therefore, nontoxic and biocompatible natures of present materials with improved thermal and rheological properties support for their possible uses as drug delivery vehicles.

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Section: Resultssupporting

confidence: 93%

Section: Resultssupporting

confidence: 93%

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Polypropylene oxide/polyethylene oxide‐cellulose hybrid nanocomposite hydrogels as drug delivery vehicle

Prusty

Swain

2020

J of Applied Polymer Sci

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“…Additionally, chitosan/Ag-curcumin hydrogel has a swelling degree higher than chitosan hydrogel. This may be because the presence of Ag-curcumin nanoparticles in the hydrogel could expand and the network of formed hydrogel also enhanced the free spaces within its matrix; consequently, chitosan/curcumin-Ag hydrogel adsorbs extra water [31]. Such composite-based hydrogels have pH-sensitive properties; they can be used as drug release at a certain pH in a controlled manner.…”

Section: Ph-sensitivity On Swelling Behavior Of Chitosan and Chitosanmentioning

confidence: 99%

“…As reported, silver nanoparticles can interact with the cell membrane via the moiety of silver ions and interrupt the bacterial cell wall's electrical balance. After membrane destruction, DNA and RNA together with other cytoplasmic fluids are emitted, into the extracellular matrix prior to the death of the cell [31,36]. Also, the action effect of curcumin molecules act as both stabilizing and reducing agent resulting in a higher bactericidal effect.…”

Section: Antibacterial Activitymentioning

confidence: 99%

Antibacterial Properties and pH Sensitive Swelling of Insitu Formed Silver-Curcumin Nanocomposite Based Chitosan Hydrogel

El‐Hady

Saeed

2020

Polymers

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A simple method was used to prepare curcumin/silver nanocomposite based chitosan hydrogel. In an alkaline medium, chitosan and chitosan nanocomposite hydrogels were prepared using the physical crosslinking method. The prepared hydrogels were stable for a long period at room temperature. In one step, silver nanoparticles were prepared insitu using silver nitrate solution and curcumin oxide within the hydrogel network formation. In the meantime, curcumin compound served as both a reducing and stabilizing agent. The structure and surface morphology of nanocomposite hydrogels were characterized by FTIR, SEM, and EDX analysis confirmed the formation of silver nanoparticles within the hydrogel network. Moreover, Images of TEM showed a spherical shape of silver nanoparticles with an average size of 2–10 nm within the matrix of the hydrogel. The formation mechanism of nanocomposite based hydrogel was reported. Besides that, the effect of chitosan and silver nitrate concentrations were studied. The swelling capacity of the prepared nanocomposite hydrogels was also performed at different pH of 4, 7, and 9. From the experimental results, the swelling capacity of hydrogels depends on the concentrations of chitosan and silver nitrate. The prepared composite based hydrogel exceeds a higher swelling degree than chitosan hydrogels at low pH. The antibacterial activity of the nanocomposite hydrogels was also examined; the results showed that the prepared nanocomposite hydrogels outperformed the pure chitosan hydrogels. This shows them to be a promising material for the biomedical field as a wound dressing and drug release.

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Polymeric Nanoplatforms for the Delivery of Antibacterial Agents

Chen

Huang

Jin

2022

Macro Chemistry & Physics

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Antibiotic therapy is the first choice for the treatment of bacterial infections in the clinic. However, the continuously increasing bacterial resistance makes traditional antibiotic therapy difficult to achieve ideal therapeutic performance, necessitating the development of new antibacterial strategies. Polymeric nanoparticles have received much attention in biomedical applications. They can be used as nanocarriers to deliver a variety of antibacterial agents to the infected area. Compared to traditional drug delivery systems, polymeric nanoparticles show various advantages, including improved drug stability, long circulation time, controlled drug release, selective drug accumulation, and so on. This review summarizes the current applications of polymeric nanoparticles for the delivery of antibacterial agents. First, an extensive review of the applications of polymeric nanoplatforms in the delivery of various antibacterial drugs is conducted. The mechanisms and strategies of various stimuli-responsive polymeric nanoplatforms are then discussed, especially focusing on how to improve the antibacterial efficacy and reduce the side effects. Finally, the challenges of future developments of polymeric nanoplatforms in the delivery of antibacterial agents are discussed.

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Silver Nanoparticles Incorporated in pH-Sensitive Nanocomposite Hydrogels Based on Carboxymethyl Chitosan-Poly (Vinyl Alcohol) for Use in a Drug Delivery System

Cited by 80 publications

References 46 publications

Polypropylene oxide/polyethylene oxide‐cellulose hybrid nanocomposite hydrogels as drug delivery vehicle

Polypropylene oxide/polyethylene oxide‐cellulose hybrid nanocomposite hydrogels as drug delivery vehicle

Antibacterial Properties and pH Sensitive Swelling of Insitu Formed Silver-Curcumin Nanocomposite Based Chitosan Hydrogel

Polymeric Nanoplatforms for the Delivery of Antibacterial Agents

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