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The electrooxidation of ascorbic acid (AA), acetaminophen (AC), tryptophan (Trp), and their mixture has been studied using an 8,9-dihydroxy-7-methyl-12H-benzothiazolo[2,3-b]quinazolin-12-one modified carbon nanotubes paste electrode and cyclic voltammetry, chronoamperometry, electrochemical impedance spectroscopy and square wave voltammetry methods. The sensor exhibited potent and persistent electron mediating behavior followed by well separated oxidation peaks towards AA, AC and Trp with activation overpotential. The linear response range for AA, AC and Trp were 0.07-350, 3.0-600, and 10.0-700 mM, respectively. The modified electrode was used for the determination of these compounds in biological and pharmaceutical samples.

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Both trifluoromethyl and halide groups are widely found in medicinally and pharmaceutically important compounds and, moreover, organohalides are commonly used as versatile intermediates in synthetic organic chemistry.