Silver(<scp>i</scp>) complexes with different pyridine-4,5-dicarboxylate ligands as efficient agents for the control of cow mastitis associated pathogens

Andrejević, Tina P.; Milivojević, Dušan; Glišić, Biljana Đ.; Kljun, Jakob; Stevanović, Nevena Lj.; Vojnović, Sandra; Medic, Strahinja; Nikodinović‐Runić, Jasmina; Turel, Iztok; Djuran, Miloš I.

doi:10.1039/d0dt00518e

Cited by 20 publications

(22 citation statements)

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“…The light stability of the [Ag(MCZ) 2 NO 3 ] and [Ag(MCZ) 2 ClO 4 ] complexes and silver(I) salts (AgNO 3 , AgClO 4 ) was studied in normal daylight in air atmosphere and in the dark [20,55]. The 0.05 mol/L solutions of the compounds were applied onto the following backgrounds: tissue paper, paper, glass, and synthetic leather.…”

Section: Light Stability Of the Compoundsmentioning

confidence: 99%

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Synthesis, Spectroscopy, Light Stability, Single-Crystal Analysis, and In Vitro Cytotoxic Activity on HepG2 Liver Cancer of Two Novel Silver(I) Complexes of Miconazole

Stryjska

Radko

Chęcińska

et al. 2020

IJMS

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Two novel silver(I) complexes of the biologically active ligand miconazole in the form of Ag(MCZ)2X (MCZ = 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole]; X = NO3− (1), ClO4− (2)) were synthesized and fully characterized. The complexes were obtained by reactions of Ag(I) salts with miconazole (MCZ). Silver(I) complexes were characterized by elemental analysis, 1H-NMR and infrared (IR) spectroscopy, electrospray ionization (ESI)-MS spectrometry, and X-ray-crystallography. This work also presents a cytotoxicity study of the silver(I) complexes of miconazole and appropriate silver(I) salts using Balb/c 3T3 and HepG2 cell lines. The cytotoxicity of the compounds was assessed based on four biochemical endpoints: lysosomal activity (neutral red uptake (NRU) assay), mitochondrial activity (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay), total protein content (TPC assay), and cellular membrane integrity (lactate dehydrogenase (LDH) assay). The cancer HepG2 cells were more sensitive to the complexes tested, and the most affected endpoint was cellular membrane damage compared to Balb/c 3T3 fibroblasts. Moreover, study complexes inhibited the growth of cancer cells at submicromolecular concentrations (0.26–0.47 μM) lower than that required for the anticancer agent, cisplatin, in MTT, NRU, and TPC assays. Both complexes were characterized by higher toxicity to human cancer cells (HepG2) than silver(I) salts and the free ligand. Combination of Ag(I) salts with miconazole is associated with the marked improvement of cytotoxic activities that can be considered as the significant point in the construction of a new generation of antineoplastic agents.

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Section: Light Stability Of the Compoundsmentioning

confidence: 99%

“…The light stability of the [Ag(MCZ) 2 NO 3 ] and [Ag(MCZ) 2 ClO 4 ] complexes, as well as silver(I) salts, was studied in normal daylight in air atmosphere and in the dark [20,55]. The complexes were dissolved in acetonitrile, while the silver(I) salts were dissolved in water.…”

Section: Light Stability Of Compounds 1 Andmentioning

confidence: 99%

Synthesis, Spectroscopy, Light Stability, Single-Crystal Analysis, and In Vitro Cytotoxic Activity on HepG2 Liver Cancer of Two Novel Silver(I) Complexes of Miconazole

Stryjska

Radko

Chęcińska

et al. 2020

IJMS

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“…The highest concentration used was 200 µg/mL. Candida strains used in this study included: Candida albicans ATCC 10231, C. parapsilosis ATCC 22019, C. krusei ATCC 6258, and clinical isolates from veterinary and human samples C. albicans 1c, C. albicans 1f [67], C. albicans 11, C. albicans 13 [68] and recombinant C. albicans SC5314 RFP and C. albicans SC5314 GFP [69]. For the MIC assessment, the inoculums were 1 × 10 5 colony forming units (cfu)/mL.…”

Section: Crystallographic Data Collection and Refinement Of The Structuresmentioning

confidence: 99%

“…The effect on biofilms formation and eradication of pre-formed biofilms was determined for two selected Candida strains (C. albicans ATCC 10231 and C. parapsilosis ATCC 22019). Anti-biofilm assays were conducted using a previously reported methodology [67,70] with some modifications. In the biofilm inhibition and biofilm eradication assays, inoculums were 1 × 10 6 cfu/mL.…”

Section: Anti-biofilm Activity Assessmentmentioning

confidence: 99%

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Copper(II) and Zinc(II) Complexes with the Clinically Used Fluconazole: Comparison of Antifungal Activity and Therapeutic Potential

et al. 2020

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Copper(II) and zinc(II) complexes with clinically used antifungal drug fluconazole (fcz), {[CuCl2(fcz)2].5H2O}n, 1, and {[ZnCl2(fcz)2]·2C2H5OH}n, 2, were prepared and characterized by spectroscopic and crystallographic methods. The polymeric structure of the complexes comprises four fluconazole molecules monodentately coordinated via the triazole nitrogen and two chlorido ligands. With respect to fluconazole, complex 2 showed significantly higher antifungal activity against Candida krusei and Candida parapsilosis. All tested compounds reduced the total amount of ergosterol at subinhibitory concentrations, indicating that the mode of activity of fluconazole was retained within the complexes, which was corroborated via molecular docking with cytochrome P450 sterol 14α-demethylase (CYP51) as a target. Electrostatic, steric and internal energy interactions between the complexes and enzyme showed that 2 has higher binding potency to this target. Both complexes showed strong inhibition of C. albicans filamentation and biofilm formation at subinhibitory concentrations, with 2 being able to reduce the adherence of C. albicans to A549 cells in vitro. Complex 2 was able to reduce pyocyanin production in Pseudomonas aeruginosa between 10% and 25% and to inhibit its biofilm formation by 20% in comparison to the untreated control. These results suggest that complex 2 may be further examined in the mixed Candida-P. aeruginosa infections.

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Pyridine Derivatives as Biologically Active Precursors; Organics and Selected Coordination Complexes

Khan

2021

ChemistrySelect

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Pyridine (py) is an important heterocyclic compound and is an integral part of various natural products. There are various medicines containing py ring system being available in the market to combat different human ailments. Observing the medicine market, Omeprazole, a widely used py-based drug in medicinal market since 1998. Netupitant (an antiemitic drug, since 2014) is used in combination with another drug to prevent acute and delayed vomiting and nausea associated with cancer chemotherapy led the run towards development of anticancer drugs. Several drugs have been approved by FDA for the treatment of cancer in recent years such as, Abemaciclib (2015), Lorlatinib (2018), Apalutamide (2018) and Ivosidenib (2019). Research on py on the bases of these advancements is an evergreen field and associated with greater hopes to address several disease related issues. Several compounds are in the process of clinical trials and are expected to serve various purposes in days to come. This review article deals with recent findings in py chemistry and its coordination complexes. The medicinal efficiency has been argued for organic and inorganic derivatives. Selected biological applications are hereby discussed as follow up study of our report in 2015. Suitable literature prior to 2015 has also been incorporated in appropriate places in order to cover the scope in broader sense.

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Silver(i) complexes with different pyridine-4,5-dicarboxylate ligands as efficient agents for the control of cow mastitis associated pathogens

Abstract: Silver(i) complexes with pyridine-4,5-dicarboxylates show significant activity against clinical isolates from the milk of a cow diagnosed with mastitis.

Cited by 20 publications

References 62 publications

Synthesis, Spectroscopy, Light Stability, Single-Crystal Analysis, and In Vitro Cytotoxic Activity on HepG2 Liver Cancer of Two Novel Silver(I) Complexes of Miconazole

Synthesis, Spectroscopy, Light Stability, Single-Crystal Analysis, and In Vitro Cytotoxic Activity on HepG2 Liver Cancer of Two Novel Silver(I) Complexes of Miconazole

Copper(II) and Zinc(II) Complexes with the Clinically Used Fluconazole: Comparison of Antifungal Activity and Therapeutic Potential

Pyridine Derivatives as Biologically Active Precursors; Organics and Selected Coordination Complexes

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