Silymarin: A promising cardioprotective agent

Exploring the potential of silymarin in agriculture: A review

“…And other list of diseases such as anorexia disease, cancer disease, demulcent in catarrh and pleurisy, diabete estrogen-related diseases, hemorrhoids, hydrophaints, malaria, and spleen disease [30]. Also cardioprotective effects of silymarin is reported on chemotherapeutics such as doxorubicin and cisplatin [41]. And inflammatory disorders, renal disorders, skin disorders, lung disorders, and many more [31].…”

Nanocomposite of Palladium Nanoparticles Anchored on Boron Nitride Nanosheets as a Sensor for Liver Treatment Drug Silymarin

“…It is concluded that SMR can protect and regenerate damaged liver cells from the effects of alcohol and other toxic substances by motivating protein synthesis. − Additionally, overdosing on SMR (doses greater than 1500 mg per day) can cause annoying side effects such as nausea, headaches, diarrhea, heart problems, and sexual invalidism. This fact necessitates the need to control and accurately measure the concentration of SMR in biological compounds and pharmaceutical formulations. , …”

“…This fact necessitates the need to control and accurately measure the concentration of SMR in biological compounds and pharmaceutical formulations. 9,10 So far, various methods and techniques have been used to detect SMR. These include high-performance liquid chromatography (HPLC), 11,12 HPLC-ultraviolet detection (HPLC-UV), 13 HPLC-tandem mass spectrometry, 14 and spectrophotometry.…”

Choline Glycerophosphate and Silymarin Modulate Brain and Intestinal Injuries in Rats Exposed to Gamma-Radiation

“…Silymarin is a natural herbal product extracted from the seeds and fruits of Silybum marianum, commonly known as milk thistle, contains different avonolignans (silibinin, isosilibinin, silichristin and silidianin) and has been long used to treat liver diseases (Gillessen and Schmidt 2020). Several studies have shown a bene cial effect of Silymarin supplementation in various diseases such as diabetes, metabolic syndrome (Vahabzadeh et al, 2018), cardiovascular diseases (Taleb et al, 2018& Zalat et al, 2021, memory impairments and depression (El-Elimat et al, 2019), in addition to its protective effect against sepsis-induced hepatic and renal injury (Al-Kadi et al, 2020). It was reported that silymarin may act as a chemopreventive agent and has a chemosensitizing activity against various cancers (Delmas et al, 2020).…”

“…These results are in agreement with the previous studies which indicated that silymarin attenuated the oxidative stress in the brain of rats intoxicated with AlCl3 (Aboelwafa et al, 2020) and inhibited the toxic effect of microcystin-LR on mice by increasing the reduced glutathione which may reduce reduced lipid peroxidation and protein carbonyl content in the spleen and intestine (Al-hazmi et al2019). Due to the presence of phenolic hydroxyl groups in its structure, silymarin could attenuate the oxidative stress through scavenging free radicals, inhibiting the free radical formation and preserving the cellular antioxidant status, thus preventing peroxidation of membrane lipids(Zalat et al, 2021). Likewise, GPC administration reduced the reactive oxygen and nitrogen species production in rodent models of intestine and liver ischemia-reperfusion injuries (Tokes et al, 2015 and Stri er et al, 2016).…”