Silymarin nanoemulsion against human hepatocellular carcinoma: development and optimization

Ahmad, Usama; Singh, Satya Prakash; Ahmad, Farhan Jalees; Siddiqui, Sahabjada

doi:10.1080/21691401.2017.1324465

Cited by 51 publications

(28 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Advantages of nanoemulsion over microemulsion includes requirement of low surfactant concentration (about 20-25 % for microemulsion whereas 5-10 % is sufficient for nanoemulsion). Nanoemulsion can be formulated by either high energy or low energy methods [30,31]. Nanoemulsions have good sensorial properties (rapid penetration, merging textures) and own bioactive effects (especially hydrating power) which makes them superior to the other carriers [32].…”

Section: Nanoemulsions and Microemulsionsmentioning

confidence: 99%

Strategies in Development and Delivery of Nanotechnology Based Cosmetic Products

Ahmad

Khan

et al. 2018

Drug Res (Stuttg)

Self Cite

View full text Add to dashboard Cite

The science of formulation involving cosmetic ingredients has always been a challenge since the release of active components greatly depends upon the carrier system involved and the selectivity of skin barrier. The principle obstacle of the skin resides in the epidermis and it's hard for many active components to cross it. The formulation related factors like size of particles, viscosity and lipophilicity of the components also play an important role in permeation of the dermal composition. Though widely used; conventional creams and gels still struggle in terms of success. This work focuses on nano based formulation strategies for successful delivery of cosmetic agents. Novel strategies like nanoemulsion, nanogels, liposomes, aquasomes, niosomes, dendrimers and fullerenes have paved way for successful delivery of dermal formulations to desire depths in the skin.

show abstract

Section: Nanoemulsions and Microemulsionsmentioning

confidence: 99%

Strategies in Development and Delivery of Nanotechnology Based Cosmetic Products

Ahmad

Khan

et al. 2018

Drug Res (Stuttg)

Self Cite

View full text Add to dashboard Cite

show abstract

“…Briefly, cells (5 Â 10 4 cells/well) were seeded in a 24-well culture plate and allowed to attach for 24 h, followed by CANE (5, 25 and 50 lg/ml) treatment. After 24 h of treatment, cells were washed with PBS and subsequently incubated with 20 mM H 2 DCFDA dye for 30 min [18]. Cells were washed twice with PBS, and ROS formation was immediately detected using an EPI fluorescence microscope (Nikon, Japan).…”

Section: Oxidative Stress Stainingmentioning

confidence: 99%

Carvacrol nanoemulsion evokes cell cycle arrest, apoptosis induction and autophagy inhibition in doxorubicin resistant-A549 cell line

Khan

Bahuguna

Bhardwaj

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

View full text Add to dashboard Cite

Carvacrol is a monoterpenoid flavonoid found abundantly in thyme plants. Its physiochemical instability and partial solubility in water is the principal limitation for its industrial use. Hence, we made a carvacrol nanoemulsion (CANE) using ultrasonication method and characterized it by dynamic light scattering (DLS) technique which revealed a negative surface charge (-29.89 mV) with 99.1 nm average droplet size. CANE effectively induced apoptosis in doxorubicin-resistant A549 lung carcinoma cells (A549) evident by the elevated expression of apoptotic proteins such as Bax, Cytochrome C, and Cleaved caspase 3 and 9. Also, CANE displayed cell senescence leading to cell cycle arrest by reducing CDK2, CDK4, CDK6, Cyclin E, Cyclin D1 and enhancing p21 protein expression. In addition, a potential role of CANE in the inhibition of autophagy was noted by evaluating the reduced conversion of LC-3 I to II. Beside this, a down-regulation of important autophagy markers ATG5 and ATG7 and upregulation of p62 were detected in response to CANE. We conclude that the synthesized CANE has potential to cause cell senescence, cell cycle arrest, autophagy inhibition and apoptosis in A549 cells and could be used as a potential candidate for lung cancer therapy.

show abstract

“…6. Nanoemulsions have small-sized droplets having greater surface area providing greater absorption [20]. 7.…”

Section: Advantagesmentioning

confidence: 99%

Nanoemulsion: An Advanced Vehicle For Efficient Drug Delivery

et al. 2017

Self Cite

View full text Add to dashboard Cite

Advanced drug delivery system has now gained preference over the conventional drug delivery system. One such research is nanoemulsion which is famous among the researchers because of ease of formation, stability, clarity, increased absorption rate leading to increasing in bioavailability and potential to form a formulation with both lipophilic as well as the hydrophilic drug. Long lasting stability (up to years) and ability to encapsulate both lipophilic and hydrophilic drug has given this colloidal system a valuable position in drug delivery. This article contains information on components required for its fabrication, preparation methods and evaluation parameters along with its application in drug delivery and future aspects of this advanced drug delivery system.

show abstract

Silymarin nanoemulsion against human hepatocellular carcinoma: development and optimization

Abstract: Our results concluded that nanoemulsion may be an efficient carrier for oral delivery of silymarin against human hepatocellular carcinoma without damaging normal cells.

Cited by 51 publications

References 43 publications

Strategies in Development and Delivery of Nanotechnology Based Cosmetic Products

Strategies in Development and Delivery of Nanotechnology Based Cosmetic Products

Carvacrol nanoemulsion evokes cell cycle arrest, apoptosis induction and autophagy inhibition in doxorubicin resistant-A549 cell line

Nanoemulsion: An Advanced Vehicle For Efficient Drug Delivery

Contact Info

Product

Resources

About