SimAmph: An agent-based simulation model for exploring the use of psychostimulants and related harm amongst young Australians

Perez, Pascal; Dray, Anne; Moore, David; Dietze, Paul; Bammer, Gabriele; Jenkinson, Rebecca; Siokou, Christine; Green, Rachael; Hudson, Susan L.; Maher, Lisa

doi:10.1016/j.drugpo.2011.05.017

Cited by 15 publications

(19 citation statements)

References 17 publications

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“…The studies we identified conceptualized, described or modelled systems of interest to alcohol-harm prevention research primarily in the United States (n = 38) [22,23,29,, Australia (n = 17) [28,31,[77][78][79][80][81][82][83][84][85][86][87][88][89][90][91] and the United Kingdom (n = 7) [26,[92][93][94][95][96][97]. We also found examples of generic alcohol systems (n = 16) [24,93,[98][99][100][101][102][103][104][105][106][107][108][109][110][111], as well as examples from Sweden (n = 2) [112,113], South Africa (n = 2) [114,115], Canada (n = 1) [116], Denmark (n = 1)…”

Section: Resultsmentioning

confidence: 99%

“…These refer to computational models which model non-linear causal relationships between system elements, which may operate at varying temporal and spatial scales in order to understand emergent patterns of system behaviour [22,31]. The majority of the dynamic simulations we identified described the process of developing, or developed, ABMs (n = 29) [28,31,[42][43][44][45][46]58,60,62,64,[74][75][76][77][78]81,83,84,[87][88][89][90]92,[96][97][98]107,119] or advocated for the use of, or developed, system dynamics (SD) models for alcohol-harm prevention (n = 9) [22,23,26,59,60,73,91,99,100]. ABMs model individual agents with different personal characteristics who interact with other agents according to 'rules' that govern their behaviour within a specific environment [42,83].…”

Section: Dynamic Simulation Modellingmentioning

confidence: 99%

“…Several models were explicitly theory-led [43,58,64,65,[74][75][76]92,116], whereas the majority drew on implicit theories. Most of the theories informing models were individual-level and concerned individuals' behaviours, particularly peer and social influences on alcohol consumption [58,59,64,65,81,92,96,98,104,107,119]. However, some studies theorized that drinking environments or societal norms and roles may also influence consumption and alcohol-related harms [42,43,[74][75][76].…”

Section: Dynamic Simulation Modellingmentioning

confidence: 99%

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Applying a complex systems perspective to alcohol consumption and the prevention of alcohol‐related harms in the 21st century: a scoping review

et al. 2021

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Background and Aims A complex systems perspective has been advocated to explore multi-faceted factors influencing public health issues, including alcohol consumption and associated harms. This scoping review aimed to identify studies that applied a complex systems perspective to alcohol consumption and the prevention of alcohol-related harms in order to summarize their characteristics and identify evidence gaps. Methods Studies published between January 2000 and September 2020 in English were located by searching for terms synonymous with 'complex systems' and 'alcohol' in the Scopus, MEDLINE, Web of Science and Embase databases, and through handsearching and reference screening of included studies. Data were extracted on each study's aim, country, population, alcohol topic, system levels, funding, theory, methods, data sources, time-frames, system modifications and type of findings produced. Results Eighty-seven individual studies and three systematic reviews were identified, the majority of which were conducted in the United States or Australia in the general population, university students or adolescents. Studies explored types and patterns of consumption behaviour and the local environments in which alcohol is consumed. Most studies focused on individual and local interactions and influences, with fewer examples exploring the relationships between these and regional, national and international subsystems. The body of literature is methodologically diverse and includes theory-led approaches, dynamic simulation models and social network analyses. The systematic reviews focused on primary network studies. ConclusionsThe use of a complex systems perspective has provided a variety of ways of conceptualizing and analyzing alcohol use and harm prevention efforts, but its focus ultimately has remained on predominantly individual-and/or local-level systems. A complex systems perspective represents an opportunity to address this gap by also considering the vertical dimensions that constrain, shape and influence alcohol consumption and related harms, but the literature to date has not fully captured this potential.

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Section: Resultsmentioning

confidence: 99%

Section: Dynamic Simulation Modellingmentioning

confidence: 99%

Section: Dynamic Simulation Modellingmentioning

confidence: 99%

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Applying a complex systems perspective to alcohol consumption and the prevention of alcohol‐related harms in the 21st century: a scoping review

et al. 2021

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“…Diverse modeling techniques (i.e. agent‐based modeling, SDM) have been utilized to study complex systems among various health‐related domains, including obesity , chronic disease , illicit drug use and health‐care .…”

Section: Computational Modeling and Simulationmentioning

confidence: 99%

Moving alcohol prevention research forward—Part II: new directions grounded in community‐based system dynamics modeling

et al. 2017

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“…Casein kinase 1 (CK1) was previously shown to phosphorylate TDP-43 in vitro and in vivo ( Hasegawa et al, 2008 ; Kametani et al, 2009 ; Nonaka et al, 2016 ). CK1 is a family of serine/threonine-selective kinases that phosphorylate key proteins in various physiological and pathological processes such as development, metabolism, cancer, and neurodegenerative disorders ( Cheong and Virshup, 2011 ; Cozza and Pinna, 2016 ; Cruciat, 2014 ; Jiang, 2017 ; Perez et al, 2012 ). In addition, CK1 inhibitors were shown to reduce TDP-43 phosphorylation and toxicity in a variety of models, including immortalized mammalian cell lines, fly and mouse neurons, and human cells derived from ALS and FTD patients ( Salado et al, 2014 ; Alquezar et al, 2016 ; Martínez-González et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

CHMP2B regulates TDP-43 phosphorylation and cytotoxicity independent of autophagy via CK1

Deng

Sun

Yue

et al. 2021

Journal of Cell Biology

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The ESCRT protein CHMP2B and the RNA-binding protein TDP-43 are both associated with ALS and FTD. The pathogenicity of CHMP2B has mainly been considered a consequence of autophagy–endolysosomal dysfunction, whereas protein inclusions containing phosphorylated TDP-43 are a pathological hallmark of ALS and FTD. Intriguingly, TDP-43 pathology has not been associated with the FTD-causing CHMP2BIntron5 mutation. In this study, we identify CHMP2B as a modifier of TDP-43–mediated neurodegeneration in a Drosophila screen. Down-regulation of CHMP2B reduces TDP-43 phosphorylation and toxicity in flies and mammalian cells. Surprisingly, although CHMP2BIntron5 causes dramatic autophagy dysfunction, disturbance of autophagy does not alter TDP-43 phosphorylation levels. Instead, we find that inhibition of CK1, but not TTBK1/2 (all of which are kinases phosphorylating TDP-43), abolishes the modifying effect of CHMP2B on TDP-43 phosphorylation. Finally, we uncover that CHMP2B modulates CK1 protein levels by negatively regulating ubiquitination and the proteasome-mediated turnover of CK1. Together, our findings propose an autophagy-independent role and mechanism of CHMP2B in regulating CK1 abundance and TDP-43 phosphorylation.

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SimAmph: An agent-based simulation model for exploring the use of psychostimulants and related harm amongst young Australians

Cited by 15 publications

References 17 publications

Applying a complex systems perspective to alcohol consumption and the prevention of alcohol‐related harms in the 21st century: a scoping review

Applying a complex systems perspective to alcohol consumption and the prevention of alcohol‐related harms in the 21st century: a scoping review

Moving alcohol prevention research forward—Part II: new directions grounded in community‐based system dynamics modeling

CHMP2B regulates TDP-43 phosphorylation and cytotoxicity independent of autophagy via CK1

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