Similar Effects of Selective Laser Trabeculoplasty and Prostaglandin Analogs on the Permeability of Cultured Schlemm Canal Cells

Alvarado, Jorge A.; Iguchi, Rumiko; Martínez, Juan Gallardo; Trivedi, Sheetal; Shifera, Amde Selassie

doi:10.1016/j.ajo.2010.03.012

Cited by 51 publications

(50 citation statements)

References 23 publications

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“…Second, PGs and selective laser trabeculoplasty may share a common mechanism of pressure-lowering effects. 41 PGs affect SC endothelial cells directly or indirectly through modulating cytokine levels (IL-1a, IL-1b, TNF-a, and IL-8) produced by TM cells. 41,42 PGs can induce intercellular junction disassembling and a 4-to 16-fold increase in conductivity of cultured SC cells.…”

Section: Discussionmentioning

confidence: 99%

“…41 PGs affect SC endothelial cells directly or indirectly through modulating cytokine levels (IL-1a, IL-1b, TNF-a, and IL-8) produced by TM cells. 41,42 PGs can induce intercellular junction disassembling and a 4-to 16-fold increase in conductivity of cultured SC cells. Histologic examination in Bahler's study found that PGs can cause focal detachment and loss of SC endothelial cells and extracellular matrix in some areas of the TM.…”

Section: Discussionmentioning

confidence: 99%

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Expansion of Schlemm's Canal by Travoprost in Healthy Subjects Determined by Fourier-Domain Optical Coherence Tomography

Chen¹,

Huang²,

Zhang³

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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PURPOSE.To determine the effect of travoprost 0.004% on Schlemm's canal (SC) in healthy human eyes using Fourierdomain optical coherence tomography (FD-OCT).METHODS. Twelve healthy volunteers were recruited for a double-blind, placebo-controlled, randomized, and paired comparison study. Right eyes of subjects were randomly assigned to receive either travoprost 0.004% or placebo; the contralateral eye received the other treatment. FD-OCT imaging of SC and measurements of IOP were carried out before and at 1, 2, 4,6,8,12,24,36, 48, 60, 72, and 84 hours after eye drop instillation.RESULTS. After instillation of travoprost eye drops, IOP gradually reduced, and the SC lumens expanded, while those values remained unchanged in placebo treated eyes. At 8 hours after the travoprost administration, the mean SC area increased 90.30% and 90.20%, respectively, in the nasal and temporal quadrant of the treated eyes as compared with the placebo group. The SC area and IOP showed a similar pattern of changes at most time points examined. In travoprost-treated eyes, a statistically significant correlation between SC area and IOP is observed (r ¼ À0.2817; P ¼ 0.0004). Measurements of the SC area showed sufficient repeatability and reproducibility.CONCLUSIONS. SC can be noninvasively imaged and quantitatively assessed in the living healthy human eye by FD-OCT. Travoprost treatment leads to SC lumen expansion accompanied by a drop of IOP in the healthy eye, likely as a result of the enhancement of pressure sensitive trabecular meshwork outflow induced by travoprost. (Invest Ophthalmol Vis Sci.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Expansion of Schlemm's Canal by Travoprost in Healthy Subjects Determined by Fourier-Domain Optical Coherence Tomography

Chen¹,

Huang²,

Zhang³

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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“…Comparisons have been made between the effects of laser treatment and prostaglandins in SC monolayer permeability. Cells treated by laser, media conditioned from lasered cells, or prostaglandins all show a reduction in levels of tight junctions and a concomitant increase in cell conductivity [130]. Modulation of SC permeability by prostaglandins further indicates an effect on enhancement of outflow through the conventional pathway.…”

Section: Traditional Topical Medications In the Management Of Glaucomamentioning

confidence: 96%

Open-angle glaucoma: therapeutically targeting the extracellular matrix of the conventional outflow pathway

O’Callaghan

Cassidy

Humphries

2017

Expert Opinion on Therapeutic Targets

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Introduction:Ocular hypertension in open-angle glaucoma is caused by a reduced rate of removal of aqueous humour (AH) from the eye, with the majority of AH draining from the anterior chamber through the conventional outflow pathway, comprising the trabecular meshwork (TM) and Schlemm's Canal. Resistance to outflow is generated, in part, by the extracellular matrix (ECM) of the outflow tissues. Current pressure-lowering topical medications largely suppress AH production, or enhance its clearance through the unconventional pathway. However, therapies targeting the ECM of the conventional pathway in order to decrease intraocular pressure have become a recent focus of attention. Areas covered: We discuss the role of ECM of the TM in outflow homeostasis and its relevance as a target for glaucoma therapy, including progress in development of topical eye formulations, together with gene therapy approaches based on inducible, virally-mediated expression of matrix metalloproteinases to enhance aqueous outflow. Expert opinion: There remains a need for improved glaucoma medications that more specifically act upon sites causative to glaucoma pathogenesis. Emerging strategies targeting the ECM of the conventional outflow pathway, or associated components of the cytoskeleton of TM cells, involving new pharmacological formulations or genetically-based therapies, are promising avenues of future glaucoma treatment. ARTICLE HISTORY

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“…However, this last measure presents some controversial aspects. As mentioned above, the post-operative inflammation with its characteristic cytokine expression profile may play a pivotal role in the intraocular pressure-lowering effect of SLT via the enhancement of Schlemm's endothelial cells permeability (Alvarado et al, 2005;Alvarado, Iguchi, Martinez, Trivedi, & Shifera, 2010).…”

Section: Post-treatment Medicationsmentioning

confidence: 99%

Selective Laser Trabeculoplasty

Pignatto¹,

Veritti²,

Gabai³

et al. 2011

Glaucoma - Current Clinical and Research Aspects

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Similar Effects of Selective Laser Trabeculoplasty and Prostaglandin Analogs on the Permeability of Cultured Schlemm Canal Cells

Cited by 51 publications

References 23 publications

Expansion of Schlemm's Canal by Travoprost in Healthy Subjects Determined by Fourier-Domain Optical Coherence Tomography

Expansion of Schlemm's Canal by Travoprost in Healthy Subjects Determined by Fourier-Domain Optical Coherence Tomography

Open-angle glaucoma: therapeutically targeting the extracellular matrix of the conventional outflow pathway

Selective Laser Trabeculoplasty

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