This study investigated the effects of Pictologics (PLS) method developed by Author (2004) on English vocabulary learning by Malaysian year six primary school students (N=118). It also examined the probable gender differences (N=54, p≤.01). In a pretest-posttest control-group design, students in two public schools in Penang, Malaysia, participated in this experiment. They were almost equally divided into the treatment group which received their training with PLS, and the control group that received their training via a conventional method. A 50-item TOEFL vocabulary test was the instrument. The data revealed that students under PLS obtained a significantly higher gain score in the vocabulary test. However, the difference between the vocabulary gain score between the male and female students in the treatment group was not significant. Briefly introducing PLS in light of the schema theory, this paper encourages teachers to be trained and students be taught to sufficiently use the PLS techniques to enhance teaching and learning English vocabulary.