Simple and Convenient Synthesis of (±)-Bakuchiol

Abstract

A simple and convenient synthesis of (±)-bakuchiol has been developed. The key intermediate was obtained in only one step from the easily available starting material, citral, by an 1,4-addition procedure. (±)-Bakuchiol was finally produced in 4 steps to give 50% overall yield.

Bakuchiol – a natural meroterpenoid: structure, isolation, synthesis and functionalization approaches

“…In the same year, Chen and Li (2008) 56 demonstrated simple and convenient synthetic route for rac -bakuchiol. Here, they prepared key intermediate 33 via 1,4 addition of citral (32) with vinylmagnesium bromide under Cu( i ) catalyst.…”