Simple and efficient synthesis of 2,4,5-triarylsubstituted imidazole derivatives via a multicomponent reaction using microwave irradiation

Hanoon, H. D.; M.Radhi, Sajid; Abbas, Sawsan Khudhair

doi:10.1063/1.5123062

Cited by 5 publications

(3 citation statements)

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“…The preparatory methods of imidazole nucleus have been tried with the possible greener approach with the high atom economy and less catalytic load to ally with the current pharmaceutical need. [ 22, 92–97 ]…”

Section: Synthesis Of Imidazolementioning

confidence: 99%

“…[91] The preparatory methods of imidazole nucleus have been tried with the possible greener approach with the high atom economy and less catalytic load to ally with the current pharmaceutical need. [22,[92][93][94][95][96][97] 4 | CONCLUSIONS It's been a long history of science; synthesizing heterocyclic inefficient and greener ways is still challenging for synthetic chemists. Various approaches have been published with or without catalyst and step and multi-component; however, the multi-component reaction tends toward the latest synthetic and accepted protocol.…”

Section: Imidazolementioning

confidence: 99%

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Versatile imidazole synthesis via multicomponent reaction approach

Chaudhary

Singla

Arya

et al. 2022

Journal of Heterocyclic Chem

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Chemists found Imidazole as a multipurpose nucleus, primarily notable for its biological role in drug discovery. This compilation of the reports gives information regarding the development and the previous background of the synthesis of the nucleus. However, the synthesis through multicomponent is taken to narrow the report. The importance of the multicomponent reactions with many nucleus has been part of the heavy literature; however, the synthesis of the bioactive scaffold as imidazole has been highlighted here with the essential points. The emphasis of the review is to show the multicomponent approach

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Section: Synthesis Of Imidazolementioning

confidence: 99%

Section: Imidazolementioning

confidence: 99%

Versatile imidazole synthesis via multicomponent reaction approach

Chaudhary

Singla

Arya

et al. 2022

Journal of Heterocyclic Chem

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“…An imidazolecontaining medications have been widely used to 32 treat a range of diseases, including antibiotic infections, in recent years. [5][6], antifungal [7][8], anti-inflammatory [9][10], antiviral [11][12], anti-parasitic [13][14], anticancer [10][11][12][13][14][15], antihistamine [16][17]and enzyme inhibition [15][16][17][18]. As demonstrated in Table 1, Imidazole and its derivatives are employed in a variety of medical applications.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of some Transition Metals Complexes with new Ligand Azo Imidazole Derivative

Ward

Musa

Nasif

2022

MJS

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AZO complexes synthesized by binding metal ions as Mn(II), Co(II), Ni(II) and Cu(II), with the ligand (L) [ethyl 4-((E)-(5-oxo-1-(((1E,2E)-3-phenylallylidene)amino)-2-thioxo-2,5-dihydro-1H-imidazol-4-yl)diazenyl)benzoate] was prepared from three steps ,first step preparation Schiff base product of condensation reaction by reaction Thiosemicarbazide with cinnamaldeyde, second step preparation the Imidazole ring close by reaction ligand 1 with chloroethylacetate, finally preparation Azo ligand(Diazanium compound) by reaction ligand 2 with benzocain. Characterized the ligands and complexes in their solid state using the elemental micro analysis (C.H.N.S), flame atomic absorption. UV-vis spectroscopy, FT-IR, magnetic susceptibility measurements, Mass spectrum, 1H-NMR spectra and electrical molar conductivity. These techniques produced comparable results with those obtained for the solid complexes. From the data of all techniques, octahedral geometry was proposed for Mn(II), Co(II), Ni(II) and Cu(II) complexes.

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