Simple and Fast Determination of Some Phenethylamines in Illicit Tablets by Base-Deactivated Reversed Phase HPLC

Longo, Marco; Martines, Cristina; Rolandi, L; Cavallaro, A.

doi:10.1080/10826079408013166

Cited by 18 publications

(9 citation statements)

References 14 publications

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“…The wavelength 210 nm had to be chosen because of lack of chromophoric groups in the amphetamine molecule. The second wavelength, 285 nm, was more specific for the methylenedioxylate group in the other amphetamines [12] and of the internal standard. In this way possible interferences were taken into account.…”

Section: Selectivitymentioning

confidence: 99%

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Analysis of ecstasy with a monolithic reversed-phase column

Schneider

Kovar

2003

Chromatographia

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SummaryA new, rapid, and precise liquid chromatographic method has been developed for simultaneous identification and quantification of amphetamine, N-methyl-3,4-methylenedioxymetamphetamine, N-ethyl-3,4-methylenedioxymetamphetamine, and N-methyl-l-(3,4-methylenedioxyphenyl)-2-butanamine in the presence of other constituents. The compounds were separated on a monolithic column with a gradient prepared from acetonitrile and 20 mM monobasic potassium buffer at a flow rate of 1.5 mL min 1 .Quantitation was performed with metoclopramide as internal standard. Use of different flow rates was investigated and enabled reduction of the separation time from 11 to 3.5 min for seven substances. The method was then applied to ten seized tablets to identify and quantify their active ingredients.als is now available commercially [16]. These Chromolith columns (Merck, Darmstadt, Germany), described as 'monolithic' in nature, consist of one rod of continuous porous silica [17]. Because of their special structure, these columns generate little back-pressure when high mobile-phase flow rates are used and therefore enable faster separations [18 20]. Thus the limitation of high back-pressures capable of destroying a packed column is of minor interest when using monolithic columns. Part of the development of our method was evaluation of this advantage when using the Chromolith SpeedROD RP-18e HPLC column to analyze the amphetamines.

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Section: Selectivitymentioning

confidence: 99%

“…A chromatogram obtained from all the substances is shown in Figure 2. Detection was performed by setting two different wavelengths (see Chromatographic Conditions), by adapting a method presented elsewhere [12]. The wavelength 210 nm had to be chosen because of lack of chromophoric groups in the amphetamine molecule.…”

Section: Selectivitymentioning

confidence: 99%

Analysis of ecstasy with a monolithic reversed-phase column

Schneider

Kovar

2003

Chromatographia

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“…A different approach to the analysis of basic drugs has been the use of base-deactivated columns ( 8 ) in which We describe here the simultaneous analysis of compounds I-IV by RP-HPLC performing the separation with an alkaline-stable stationary phase , namely AluspherR RPselect B. Validation data are presented for the determination of the drugs in commercial samples of rinological formulations.…”

Section: Simultaneous Determination Of Ephedrine and 2-imidazolines Imentioning

confidence: 99%

Simultaneous Determination of Ephedrine and 2-Imidazolines in Pharmaceutical Formulations by Reversed-Phase Hplc

Orsi¹,

Gagliardi²,

Cavazzutti³

et al. 1995

Journal of Liquid Chromatography

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A simpleIrapidl and accurate method for the determination of naphazoline, oxymetazoline, xylometazoline, and ephedrine in rhological solutions using reversed-phase HPLC was developed. It involves the use of alumina coated with polybutadl7ne as the stationary phase, acetonitrile-aqueous 10 M NaOH (10:90) as the initial mobile phase with a linear gradient from 10 to 80% acetonitrile in 25 min, and detection at 224 nm. The only sample preparation is its dilution with water. Linearity and precision of the method have been assessed. The assay results obtained for various formulations were in agreement with the declared amounts.

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“…A variety of analytical techniques, for example titrimetry [6], spectroscopy [7], capillary electrophoresis [8][9][10], liquid chromatography [11][12][13][14] and gas chromatography [15][16][17][18] have been used for quantization of amphetamine and methamphetamine in different real samples. Undoubtedly, GC coupled on-line to a MS detection system is the most powerful technique for identification and confirmation of amphetamines.…”

Section: Introductionmentioning

confidence: 99%