Simultaneous Determination of Ephedrine and 2-Imidazolines in Pharmaceutical Formulations by Reversed-Phase Hplc

Orsi, Daniela; Gagliardi, Luigi; Cavazzutti, G.; Mediati, M. G.; Tonelli, Domenica

doi:10.1080/10826079508010447

Cited by 23 publications

(8 citation statements)

References 9 publications

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“…Several analytical methods are used to determine naphazoline (NPZ); most are photometric [25] and chromatographic methods. Different types of chromatographic method have been reported in the literature, including thin-layer chromatography [26,27], gas chromatography [28], and high-performance liquid chromatography [29,30,31,32,33,34]. The literature also contains a report of the use of a fluorimetric method [35] to determine naphazoline in ophthalmic solution at λ ex/em =280/327 nm, with a linear range between 0.1 and 0.5 mg mL -1 .…”

Section: Introductionmentioning

confidence: 99%

Comparison of three different phosphorescent methodologies in solution for the analysis of naphazoline in pharmaceutical preparations

Díaz¹,

Terrones

Segura‐Carretero³

et al. 2004

Analytical and Bioanalytical Chemistry

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We present results from a comparative study of three proposed phosphorimetric methods for determination of naphazoline (NPZ) in solution. The first method is based on use of micelles to stabilize phosphorescence signals in solutions at room temperature (MS-RTP). The second is based on the use of a heavy atom salt and sodium sulfite as an oxygen scavenger to obtain room-temperature phosphorescence (HAI-RTP) in solution. The last method employs an optical sensor for NPZ based on the phosphorescent properties of the analyte on a solid sensor phase. The aim of this work was to compare time consumption, simplicity, sensitivity, selectivity, detection, and quantification limits for use of these three phosphorimetric methods to determine naphazoline in pharmaceutical preparations. The most simple, sensitive, and reproducible of the three methods for naphazoline analysis is the HAI-RTP method. Detection limits are 4.9, 1.7, and 9.4 ng mL(-1), respectively, for the MS-RTP, HAI-RTP, and optosensor methods.

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Section: Introductionmentioning

confidence: 99%

Comparison of three different phosphorescent methodologies in solution for the analysis of naphazoline in pharmaceutical preparations

Díaz¹,

Terrones

Segura‐Carretero³

et al. 2004

Analytical and Bioanalytical Chemistry

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“…Several methods have been reported for the determination of SCG in pharmaceutical preparations such as spectrophotometry [3,4], electrophoresis [5], electrochemical [6,7] and HPLC methods [8][9][10][11][12][13][14]. OXMT has also been analyzed by several methods in pharmaceutical preparations such as spectrophotometry [3,[15][16][17][18][19][20][21][22][23], capillary electrophoresis [24,25], gas chromatography [26,27] and HPLC [28][29][30][31][32][33][34][35]. To the best of our knowledge, Abdel-Aziz et al [3] developed new accurate, sensitive and selective spectrophotometric and spectrofluorimetric methods for determination of SCG and OXMT.…”

Section: Introductionmentioning

confidence: 99%

Spectral resolution and simultaneous determination of oxymetazoline hydrochloride and sodium cromoglycate by derivative and ratio-based spectrophotometric methods

et al. 2015

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Sodium cromoglycate (SCG) and oxymetazoline hydrochloride (OXMT) are administered in combination for effective treatment of nasal congestion and allergy. In this work, SCG was determined using direct spectrophotometry by measuring its zero order absorption spectra at its λmax 320.6 nm where OXMT showed zero absorbance. On the other hand, four simple, sensitive and precise spectrophotometric methods were developed and validated for the determination of OXMT in the presence of SCG in their laboratory prepared mixtures and pharmaceutical formulation, without preliminary separation; Method A: first derivative spectrophotometric method [ 1 D], Method B: first derivative of ratio spectra method [ 1 DD], Method C: ratio difference spectrophotometric method [RDSM] and Method D: ratio subtraction method [RSM]. Ratio manipulating methods (Method B, C and D) were done using divisor of 10.00 µg/mL SCG. Linear correlation was obtained in range 4-22 µg/mL for OXMT by methods A, B and D and 6-22 µg/mL for method C. All methods were validated in compliance with the International Conference on Harmonization (ICH) guidelines and satisfactory results were obtained. No significant difference was noted between the developed methods and the official one with respect to accuracy and precision.

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“…Several different methods have been used for the determination of oxymetazoline hydrochloride OMCl, including high-performance liquid chromatography (HPLC), [2][3][4][5][6][7][8] gas chromatography, 9 a two-phase titration procedure 10 and spectrophotometric methods. [11][12][13][14][15][16] No potentiometric methods have yet been reported for the determination of OM.…”

Section: Introductionmentioning

confidence: 99%

Construction and Analytical Applications of Plastic Membrane Electrode for Oxymetazoline Hydrochloride

Issa

Zayed²

2004

ANAL. SCI.

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A new oxymetazoline (OM) ion-selective PVC membrane electrode based on the ion associate of OM with phosphotungstic acid was prepared. The electrode exhibits a linear response with a mean calibration graph slope of 57.16 mV decade -1 at 25˚C within the concentration range of 1.96 × 10 -5 -1 × 10 -2 M OMCl. The change in the pH within the range of 1.0 -9.4 did not affect the electrode performance. The standard electrode potentials were determined at different temperatures and used to calculate the isothermal coefficient of the electrode (-0.001233 V). The electrode showed a very good selectivity for OM with respect to a large number of inorganic cations and compounds. The standard addition method and potentiometric titration were applied to the determination of (OM) with RSD not exceeding 1.19%.

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Simultaneous Determination of Ephedrine and 2-Imidazolines in Pharmaceutical Formulations by Reversed-Phase Hplc

Cited by 23 publications

References 9 publications

Comparison of three different phosphorescent methodologies in solution for the analysis of naphazoline in pharmaceutical preparations

Comparison of three different phosphorescent methodologies in solution for the analysis of naphazoline in pharmaceutical preparations

Spectral resolution and simultaneous determination of oxymetazoline hydrochloride and sodium cromoglycate by derivative and ratio-based spectrophotometric methods

Construction and Analytical Applications of Plastic Membrane Electrode for Oxymetazoline Hydrochloride

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