Simple and less cost but not effective

Amylin, bariatric surgery, and type 2 diabetes mellitus

“…3,[5][6][7][8] Among the aforementioned strategies, some of them are effective, but needing more efficacious and better tolerable treatment approaches, and by contrast, some of them are more effective, but costly, associated with a non-negligible risk of complications, and not all people are eligible for this strategy. 3,[5][6][7][8][9][10] Recently, bariatric surgery over the past 60 years has impressively attracted our attention not only in providing a means of achieving substantial weight loss but also in giving us many novel insights on the pathophysiology of obesity. 11 There are two main approaches currently performed widely as Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG), and the former creates a small gastric pouch around 30 mL being anastomosed to the proximal jejunum with a transection at 30-75 cm from the ligament of Treitz to form the "alimentary limb" which further connects the excluded biliopancreatic limb approximately 75-150 cm distal to the gastrojejunostomy to restore the continuity of the small intestine, and the latter involves dividing the stomach along its vertical length to create a sleeve and removing three-quarters of gastric volume, in both of which decrease the absorption of food intake and result in weight loss due to changes in the physiology of body weight regulation.…”