The single‐electron transistor (SET) is a three‐terminal device, the electric characteristics of which are governed by the movement of single electrons. The SET's physical size is quite small and its performance, such as ON‐OFF current ratio, improves as its size is reduced. The SET is therefore thought to be a promising device for large‐scale and low‐power integrated circuits. In addition, its current characteristics are unique and much different from those of conventional transistors. This makes the SET one of the best functional devices, and a rich variety of architectures for SET‐based logic circuits have been proposed and experimentally tested. This chapter describes SET research from the viewpoint of logic‐circuit applications.