Simple bone cysts in children treated with intracystic fibrin sealant injection

Tang, Xueyang; Liu, Lijun; Peng, Mingxing; Xiang, Bo

doi:10.1097/00029330-200603020-00018

Cited by 8 publications

(4 citation statements)

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“…In periodontal surgery, sealants are used to anchor gingival grafts and to enhance reconstructive procedures as well [134]. Contrary to experimental animal studies, no immunologic reactions have been reported with fibrin components in human thus far [135]. Although the results reported in several groups are promising, it is difficult to draw definitive conclusions because most of these studies are descriptive rather than evidencebased [105,136].…”

Section: Applications Of Fibrin Sealantsmentioning

confidence: 99%

A review on endogenous regenerative technology in periodontal regenerative medicine

et al. 2010

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Section: Applications Of Fibrin Sealantsmentioning

confidence: 99%

A review on endogenous regenerative technology in periodontal regenerative medicine

et al. 2010

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“…Injections can include steroids, 13 bone marrow, 14 demineralized bone matrix, 15 calcium sulfate pellets, 16 and fibrin sealant. 17 Mechanical disruption of the cyst lining or wall is done by curettage. Structural support can be done with flexible intramedullary nailing.…”

Section: Introductionmentioning

confidence: 99%

Treatment for unicameral bone cysts in long bones: an evidence based review

Donaldson

Chundamala²,

Yandow³

et al. 2010

Orthop Rev

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The purpose of this paper is to perform an evidence based review for treatment of unicameral bone cysts. A search of MEDLINE (1966 to 2009) was conducted and the studies were classified according to levels of evidence. This review includes only comparative Level I-III studies. The systematic review identified 16 studies. There is one level I study, one level II study and the remaining 14 studies are level III. Seven of the sixteen studies had statistically different results: three studies indicated that steroid injection was superior to bone marrow injection or curettage and bone grafting; one study indicated that cannulated screws were superior to steroid injections; one study indicated resection and myoplasty was superior to steroid injection; one study indicated a combination of steroid, demineralized bone matrix and bone marrow aspirate, and curettage and bone grafting were superior to steroid injection; and one study indicated that curettage and bone grafting was superior to non-operative immobilization. Based on one Level I study, including a limited number of individuals, steroid injection seems to be superior to bone marrow injection. As steroid injections have already demonstrated superiority over bone marrow injections in a randomized clinical trial, the next step would be a prospective trial comparing steroid injections with other treatments.

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“…Various treatment options have been reported including crushing of the cyst wall and grafting, 13 total resection with bone grafting, 14,15 curettage combined with bone grafting, 16 allografting with freeze-dried crushed cortical bone, 17 homologous cancellous bone chips, 18 high-porosity hydroxyapatite components 19 or plaster-of-Paris pellets 20 and cryosurgery, 21 injection of methylprednisolone, 1,22 injection of fibrin sealant, 23 bone marrow or bone substitutes, 24,25 decompression with drilling or screws, 26,27 and intramedullary nailing. 1,3,28 Initial treatment of simple bone cysts consisted of curettage and bone grafting, and the success has ranged from 55% to 65%.…”

Section: Discussionmentioning

confidence: 99%

“…The fibrin sealant may not only supply a fibrillar network as a scaffold for new bone deposition, but also induce osteogenic cell differentiation from mesenchymal stem cells, which accelerate tissue regeneration and mineralization. 23 A few authors have advocated percutaneous multiple drilling with Kirschner wires, 27,34 or prolonged decompression of the cyst using cannulated screws left in place without corticosteroid injection. 26 The mechanism of action of percutaneous drilling and decompression is based on the concept that the lesions are caused by fluid unable to escape from the bone because of venous obstruction.…”

Section: Discussionmentioning

confidence: 99%