Simple extractive colorimetric determination of levofloxacin by acid–dye complexation methods in pharmaceutical preparations

Ashour, Safwan; Al-Khalil, Raghad

doi:10.1016/j.farmac.2005.06.007

Cited by 38 publications

(27 citation statements)

References 25 publications

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“…Fluorine, being highly electronegative, does not make available any free electron in the molecule to interact with the acidic dye and hence it does not show a characteristic color change. Valsartan dye complex behaves as a single unit held together by electrostatic force of attraction [14]. T he absorbance of valsartan shifted from 250 nm to 425 nm (bathochromic shift) after the complex formation with the dye solution.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous Spectrophotometric Determination of Valsartan and Ezetimibe in Pharmaceuticals

Ramachandran¹,

Mandal²,

Navalgund³

2011

Trop. J. Pharm Res

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Section: Discussionmentioning

confidence: 99%

Simultaneous Spectrophotometric Determination of Valsartan and Ezetimibe in Pharmaceuticals

Ramachandran¹,

Mandal²,

Navalgund³

2011

Trop. J. Pharm Res

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“…Therefore, ion-pair extractive spectrophotometry has received considerable attention for the quantitative determination of many pharmaceutical compounds [13,14,33,[53][54][55]. So far, there has been no ion-pair extractive spectrophotometry method reported for an estimation of fexofenadine hydrochloride and irbesartan with naphthol blue black.…”

Section: Introductionmentioning

confidence: 99%

Sensitive Extractional Colorimetric Analysis of Fexofenadine Hydrochloride and Irbesartan Bases Through Acid-Dye Complexation Using Naphthol Blue Black in Pure Form and Pharmaceuticals

Ashour¹

2017

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A simple, accurate and sensitive method has been presented for the determination of fexofenadine hydrochloride (FEX) and irbesartan (IRB) in bulk and pharmaceutical preparations. The method is based on the reaction of the above cited drugs with naphthol blue black (NBB) dye in solutions containing Britton buffer to form ion-pair complexes extractable with chloroform and subsequently measured spectrophotometrically at 625 nm. All the reaction conditions for the proposed methods have been studied. The reactions were extremely rapid at room temperature and the absorbance values remained unchanged for at least 24 hrs. Beer's law was obeyed in the concentration ranges 2.7-53.8 and 10-244 µg mL -1 with detection limit of 0.013 and 0.75 µg mL -1 for FEX and IRB, respectively. The proposed methods were applied successfully for the determination of FEX and IRB in pharmaceutical formulations. Interferences of the other ingredients and excipients were not observed. The results obtained were compared statistically with those obtained by the official method and showed no significant differences regarding accuracy and precision.

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“…The ion-pair extractive spectrophotometry has been applied to the estimation of numerous compounds; possessing basic moieties (secondary or tertiary amino group) by using an anionic dye as a reagent and organic solvent as an extractant. Bromophenol blue being an anionic dye has been reported to form ion-pair complexes thus offering simple and rapid spectrophotometric determination of therapeutically significant pharmaceutical compounds [33][34][35][36][37][38][39][40][41][42][43].…”

Section: Introductionmentioning

confidence: 99%

Development and validation of novel analytical methods for estimation of doxofylline in bulk and dosage forms

Sunil¹,

Saradhi

Sekaran³

et al. 2011

Eur. J. Chem.

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KEYWORDSThree simple, sensitive and accurate spectrophotometric methods (A, B and C) were developed to determine doxofylline in bulk and in its dosage forms. Method A is based on charge-transfer complex formation of the drug with p-chloranilic acid. Method B involves the formation of colored chloroform extractable ion-pair complex of the drug with bromophenol blue under acidic condition. Method C is based on ternary complex formation of the drug with molybdenum(V) thiocyanate binary complex. The colored products are quantitated spectrophotometrically at 540, 390 and 690 nm by methods A, B and C, respectively. The variables, which affected the reactions were carefully studied and optimized. The linear ranges for the proposed methods were 4-32 μg/mL (method A & B) and 2-16 μg/mL (method C). Analytical performance of the methods was statistically validated. The proposed methods were successfully applied to the analysis of doxofylline in its dosage forms and were found to be comparable with that of reference method.

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Simple extractive colorimetric determination of levofloxacin by acid–dye complexation methods in pharmaceutical preparations

Cited by 38 publications

References 25 publications

Simultaneous Spectrophotometric Determination of Valsartan and Ezetimibe in Pharmaceuticals

Simultaneous Spectrophotometric Determination of Valsartan and Ezetimibe in Pharmaceuticals

Sensitive Extractional Colorimetric Analysis of Fexofenadine Hydrochloride and Irbesartan Bases Through Acid-Dye Complexation Using Naphthol Blue Black in Pure Form and Pharmaceuticals

Development and validation of novel analytical methods for estimation of doxofylline in bulk and dosage forms

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