Simple, Fast, and Sensitive detection of artemisinin in human serum and Artemisia annua using microsensor array coupled with electrochemiluminescent imaging technique

Tang, Xiao-Chong; Xiao, Yingying; Li, Ping; Qi, Lian‐Wen

doi:10.1016/j.talanta.2018.12.016

Cited by 5 publications

(5 citation statements)

References 31 publications

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“…As comparison, the artemisinin levels found in extracts in previously published papers range from 60 µg/mL [29] to 200-500 µg/mL [30] to 6-17 mg/mL [31]. Artemisinin levels in the original plant material can also vary widely according to the source and the author, from 10-22 pg/mg of dry weight (D.W.) [32] to 1-10 µg/mg D.W. [33], and from 100-200 ng/mg D.W. in Chinese plants to 10-15 µg/mg D.W. in selected Chinese and Vietnamese hybrids [34].…”

Section: Analysis Of a Annua Extractsmentioning

confidence: 99%

Analysis of Artemisia annua extracts and related products by high performance liquid chromatography-tandem mass spectrometry coupled to sample treatment miniaturisation

Protti

Mandrioli

Mandrone

et al. 2019

Journal of Pharmaceutical and Biomedical Analysis

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Section: Analysis Of a Annua Extractsmentioning

confidence: 99%

Analysis of Artemisia annua extracts and related products by high performance liquid chromatography-tandem mass spectrometry coupled to sample treatment miniaturisation

Protti

Mandrioli

Mandrone

et al. 2019

Journal of Pharmaceutical and Biomedical Analysis

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“…Most of these analytical techniques or assays for artemisinin ( 1 ) reported until the end of year 2016 have been well documented and appraised in the book published by Tu . However, since then, several modified, and somewhat more precise and fast analytical protocols (Table ), mainly involving various HPLC systems, have been reported in the literature. The following subsections will summarise and appraise those new published protocols.…”

Section: Discussionmentioning

confidence: 99%

“…A microsensor array coupled with electrochemiluminescence imaging technique, which is a widely used analytical technique with the advantages of high sensitivity and low background signal, was used for the detection of artemisinin ( 1 ) in human serum and A. annua. The microsensor array was constructed by integrating a patterned indium tin oxide glass plate with two perforated hydrophobic paper covers. This method could show a good selectivity and stability towards artemisinin detection.…”

Section: Discussionmentioning

confidence: 99%

“…11 Microsensor array coupled with electrochemiluminescent imaging A microsensor array coupled with electrochemiluminescence imaging technique for the detection of artemisinin (1) in human serum and A. annua. 35 Raman spectroscopic analysis Qualitative and quantitative analysis of artemisinin (1) was performed using Raman spectroscopy. 36 Sensitive fluorescent assay or fluorescencebased sensing A method for the determination of artemisinin (1) by using graphene quantum dots as the fluorescent probes.…”

Section: Lc-ms Methodsmentioning

confidence: 99%

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A review on the latest advances in extraction and analysis of artemisinin

Nahar

Chen

Sarker

2019

Phytochemical Analysis

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Introduction Artemisinin (1), a well‐known natural antimalarial drug, is a sesquiterpene lactone that contains a unique peroxide bridge. Since its discovery, the amount of research into the analysis of artemisinin has increased considerably, and it has been further intensified since the Noble Prize win by Tu Youyou in the year 2015 for the discovery of artemisinin. Objective To review literature on the extraction and analysis of artemisinin, published during 2017–present, and to present an appraisal of those methods. Methodology Extensive literature search was carried out which involved, but not limited to, the use of, various databases, like Web of Knowledge, PubMed and Google Scholar, and relevant published materials including published books. The keywords used, in various combinations, with artemisinin being present in all combinations, in the search were artemisinin, Artemisia annua, analysis, extraction, quantitative, qualitative and quality control. Results During the period covered in this review, several methods of analysis of artemisinin have been reported, the most of which were liquid chromatography (LC)‐based methods. However, the use of new methods like near‐infrared analysis, fluorometirc analysis and molecular imprinting, and a significant increase in the use of computational tools have been observed. Mainly several methods involving supercritical fluid extraction and ultrasound‐assisted extraction of artemisinin have dominated the extraction area. Conclusions Newer analytical tools, as well as improved protocols for the known analytical tools, for qualitative and quantitative determination of artemisinin (1), have been made available by various researchers during the period covered by this review. Supercritical fluid extraction and ultrasound‐assisted extraction are still the methods of choice for extraction of artemisinin.

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“…Researchers, including Liu et al, have made advancements in this area by developing self-healing hydrogels for ECLbased sensing applications. [93][94][95][96][97][98][99] They prepared the transparent self-healing oxidized sodium alginate/hydrazide polyethy-lene glycol (OSA/PEG-DH) hydrogel by dynamically crosslinking covalent acylhydrazone bond. The IL 2-hydroxy-N,N,Ntrimethylethanaminium chloride and the luminescent reagent N-(aminobutyl)-N-(ethylisoluminol) (ABEI) were simultaneously immobilized in the OSA/PEG-DH hydrogel to obtain the ABEI/IL/OSA/PEG-DH hydrogel.…”

Section: Electrochemical Sensingmentioning

confidence: 99%

Hydrogels for Chemical Sensing and Biosensing

Li,

Dai,

2023

Macromol. Rapid Commun.

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The development and synthesis of hydrogels for chemical and biosensing are of great value. Hydrogels can be tailored to its own physical structure, chemical properties, biocompatibility, and sensitivity to external stimuli when being used in a specific environment. Herein, hydrogels and their applications in chemical and biosensing are mainly covered. In particular, it is focused on the manner in which hydrogels serve as sensing materials to a specific analyte. Different types of responsive hydrogels are hence introduced and summarized. Researchers can modify different chemical groups on the skeleton of the hydrogels, which make them as good chemical and biosensing materials. Hydrogels have great application potential for chemical and biosensing in the biomedical field and some emerging fields, such as wearable devices.

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Simple, Fast, and Sensitive detection of artemisinin in human serum and Artemisia annua using microsensor array coupled with electrochemiluminescent imaging technique

Cited by 5 publications

References 31 publications

Analysis of Artemisia annua extracts and related products by high performance liquid chromatography-tandem mass spectrometry coupled to sample treatment miniaturisation

Analysis of Artemisia annua extracts and related products by high performance liquid chromatography-tandem mass spectrometry coupled to sample treatment miniaturisation

A review on the latest advances in extraction and analysis of artemisinin

Hydrogels for Chemical Sensing and Biosensing

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