Simple Noninvasive Measurement of Skin Autofluorescence

Meerwaldt, Robbert; Links, Thera P.; Graaff, Reindert; Thorpe, Suzannne R.; Baynes, John W.; Hartog, Jasper W. L.; Gans, Rijk O. B.; Smit, Andries J.

doi:10.1196/annals.1333.036

Cited by 166 publications

(161 citation statements)

References 27 publications

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“…Although the reference standard for measuring AGE levels in tissues is biochemical determination in skin biopsies, skin autofluorescence (SAF) has emerged as a noninvasive, accurate, and practical method for the analysis of AGE levels in skin 11, 12. SAF‐indicated AGE levels are elevated in diabetes mellitus and end stage renal disease, and some studies suggest that they are associated with CVD independent of known CVD risk factors 13, 14, 15.…”

mentioning

confidence: 99%

Skin Autofluorescence–Indicated Advanced Glycation End Products as Predictors of Cardiovascular and All‐Cause Mortality in High‐Risk Subjects: A Systematic Review and Meta‐analysis

Cavero‐Redondo

Soriano-Cano

Álvarez‐Bueno

et al. 2018

JAHA

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BackgroundChronic deposits of advanced glycation end products produced by enzymatic glycation have been suggested as predictors of atherosclerotic‐related disorders. This study aimed to estimate the relationship between advanced glycation end products indicated by skin autofluorescence levels and the risk of cardiovascular and all‐cause mortality based on data from observational studies.Methods and ResultsWe systematically searched Medline, Embase, the Cochrane Central Register of Controlled Trials, the Cochrane Database of Systematic Reviews, and the Web of Science databases from their inceptions until November 2017 for observational studies addressing the association of advanced glycation end products by skin autofluorescence levels with cardiovascular and all‐cause mortality. The DerSimonian and Laird random‐effects method was used to compute pooled estimates of hazard ratios and their respective 95% confidence intervals for the risk of cardiovascular and all‐cause mortality associated with levels of advanced glycation end products by skin autofluorescence. Ten published studies were included in the systematic review and meta‐analysis. Higher skin autofluorescence levels were significantly associated with a higher pooled risk estimate for cardiovascular mortality (hazard ratio: 2.06; 95% confidence interval, 1.58–2.67), which might not be important to moderate heterogeneity (I2=34.7%; P=0.163), and for all‐cause mortality (hazard ratio: 1.91; 95% confidence interval, 1.42–2.56) with substantial heterogeneity (I2=60.8%; P=0.0.18).ConclusionsOur data suggest that skin autofluorescence levels could be considered predictors of all‐cause mortality and cardiovascular mortality in patients at high and very high risk.

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mentioning

confidence: 99%

Skin Autofluorescence–Indicated Advanced Glycation End Products as Predictors of Cardiovascular and All‐Cause Mortality in High‐Risk Subjects: A Systematic Review and Meta‐analysis

Cavero‐Redondo

Soriano-Cano

Álvarez‐Bueno

et al. 2018

JAHA

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“…[11] A black light tube, with a peak wavelength of 370 nm is used to illuminate a small region of the skin on the forearm. An optical fiber detects the emission and reflected excitation light, and a spectrometer is used to measure the intensity spectrum.…”

Section: Introductionmentioning

confidence: 99%

Assessment of advanced glycated end product accumulation in skin using auto fluorescence multispectral imaging

Larsson

Favilla²,

Strömberg

2017

Computers in Biology and Medicine

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We proposed a non-invasive, contact-less novel technique for quantifying fluorescent AGE deposits in skin tissue using a multi-spectral imaging camera setup (MSI) during ultraviolet (UV) exposure. Imaging involved applying a region-of-interest mask, avoiding specular reflections and a simple calibration. Results of a study conducted on 16 subjects with skin types ranging from fair to deeply pigmented skin, showed that AGE measured with MSI in forearm skin was significantly correlated with the AGE reference method (AGE Reader on forearm skin, R = 0.68, p = 0.005). AGE measured in facial skin was borderline significantly related to AGE Reader on forearm skin (R = 0.47, p = 0.078). These results support the use of the technique in devices for non-touch measurement of AGE content in either facial or forearm skin tissue over time.

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“…Recently, a non-invasive method to measure the skin's content of AGEs using their autofl ourescent characteristic, the AGE-Reader (DiagnOptics B.V., Groningen, The Netherlands), has been developed (107)(108)(109). The in vivo measurements of fl uorescent AGEs correlated strongly with those taken from skin biopsies specimens, as well as with the non-fl uorescent forms of AGEs (110)(111)(112).…”

Section: Age Evaluation Methodsmentioning

confidence: 99%

Glycation: Implication in Perceived Age and Dermatology

2014

RoJCED

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Perceived age comprises different facial features and it is associated with multiple external factors, one of which is high levels of serum glucose. Modern Western diet is associated with systemic elevated sugar levels. Excess sugars react with proteins, forming protein-bounded sugars involved in the process named glycation and resulting in the formation of advanced glycation end products or AGEs. This article reviews the pathophysiological mechanisms involved in glycation and AGEs' impact on tissues and organs of both healthy and diabetic individuals. Dietary advice must be an important part of medical consultation, emphasizing the benefi ts of a hypoglycemic diet. Future research aimed at discovering universal molecules that could interfere with AGE's will be a major breakthrough in the management of diabetes and aging related conditions.

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Simple Noninvasive Measurement of Skin Autofluorescence

Cited by 166 publications

References 27 publications

Skin Autofluorescence–Indicated Advanced Glycation End Products as Predictors of Cardiovascular and All‐Cause Mortality in High‐Risk Subjects: A Systematic Review and Meta‐analysis

Skin Autofluorescence–Indicated Advanced Glycation End Products as Predictors of Cardiovascular and All‐Cause Mortality in High‐Risk Subjects: A Systematic Review and Meta‐analysis

Assessment of advanced glycated end product accumulation in skin using auto fluorescence multispectral imaging

Glycation: Implication in Perceived Age and Dermatology

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