Simple Peripheral Blood Cell Parameters to Predict Prognosis in Non-Small Cell Lung Cancer

Sayan, Muhammet; Kankoç, Aykut; Özkan, Nur Dilvin; Baş, Aynur; Çelik, Ali; Kurul, İsmail Cüneyt; Aribas, Olgun Kadir; Taştepe, Abdullah İrfan

doi:10.1007/s12262-020-02237-4

Cited by 4 publications

(5 citation statements)

References 24 publications

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“… 11 , 12 The neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR) are considered reliable markers of inflammatory processes. 13 …”

Section: Discussionmentioning

confidence: 99%

Prognostic Factors Determining Survival of Patients Operated for Non-Small Cell Lung Cancer with Consideration Given to Morphological Parameters of Blood

Łochowski

Łochowska

Chałubińska-Fendler

et al. 2021

CMAR

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“… 11 , 12 The neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR) are considered reliable markers of inflammatory processes. 13 …”

Section: Discussionmentioning

confidence: 99%

Prognostic Factors Determining Survival of Patients Operated for Non-Small Cell Lung Cancer with Consideration Given to Morphological Parameters of Blood

Łochowski

Łochowska

Chałubińska-Fendler

et al. 2021

CMAR

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“…2 The majority of ongoing studies are focused on the search for other factors that can be assessed at disease onset to predict the prognosis and qualify the patient for appropriate treatment. Such studies are typically performed on a large scale, including huge panels of laboratory parameters including protein and genetic biomarkers which might indicate a biological response to oncogenesis 3,4 This biological response is accompanied by a developing inflammatory process that can be induced by serum proteins and nucleic acid products released by the tumor, eg TNF-alpha, free fractions of microRNA or free circulating DNA. Many of these molecules are undergoing testing as possible prognostic markers; however, their precise accuracy and specificity remain unknown and they are routinely used.…”

Section: Introductionmentioning

confidence: 99%

“…3 Nevertheless, it is possible to detect inflammatory processes with simple, easily available everyday tests, such as the standard complete blood count test and its calculated derivatives. 4,5 In addition, the platelet-to-lymphocyte ratio (PLR) and the neutrophil-to-lymphocyte ratio (NLR) are promising indices whose prognostic value has been discussed in cases of various malignancies. 2,4 The aim of the present study is to evaluate the prognostic value of PLR and NLR in patients receiving surgical treatment due to NSCLC.…”

Section: Introductionmentioning

confidence: 99%

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The Prognostic Significance of Preoperative Platelet-to-Lymphocyte and Neutrophil-to-Lymphocyte Ratios in Patients Operated for Non-Small Cell Lung Cancer

Łochowski

Chałubińska-Fendler

Zawadzka

et al. 2021

CMAR

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The aim of the study was to determine the prognostic significance of PLR and NLR ratios in patients operated due to non-small cell lung cancer. Material:The study group consisted of 532 (174 women, 358 men) patients with non-small cell lung cancer (NSCLC) staged IA-IIIA. The mean age was 63.6 years (range 36 to 84 years). Together with platelet/lymphocyte ratio (PLR) and neutrophil/lymphocyte ratio (NLR), the following factors were included in the statistical analysis: age, sex, smoking history, the number of leukocytes, neutrophils, and platelets, histopathology, T-stage, N-stage, concomitant diseases according to the Charlson Comorbidity Index (CCI), type of operation, adjuvant chemotherapy, and overall survival. Results: Univariate analysis showed an association between the value of PLR and NLR and the length of survival. Multivariate analysis found that the stage of advancement of the neoplastic disease (p=0.00003), adjuvant chemotherapy (p=0.009), CCI > 4 (0.00008), and PLR > 144 (p=0.001) were negative prognostic factors for survival > 2 years; however, this effect diminishes in patients surviving more than 5 years. Conclusion: PLR might serve as a prognostic factor in patients affected by NSCLC with expected two-year overall survival.

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“…9,10 Previous studies have presented that NLR could serve as a systemic inflammatory response index to provide important information regarding inflammation and immune state. NLR has been identified as a prognostic biomarker in several cancer types, including urinary tract epithelial tumors, prostate cancer, and non-small cell lung cancer (NSCLC), [11][12][13][14] although the relationship between NLR and long-term outcomes in SCLC remains to be completely understood. Thus, this study was designed to further explore the effects of NLR on the prognosis and identify other factors that modify this association in patients with SCLC.…”

Section: Introductionmentioning

confidence: 99%

<p>A Retrospective Cohort Study on Pretreated Neutrophil-to-Lymphocyte Ratio and Prognosis of Small Cell Lung Cancer: Evidence of Effect Modification by Chemotherapy Regimen</p>

Liu

Zhou

Tan

et al. 2020

CMAR

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Purpose: Neutrophil-to-lymphocyte ratio (NLR) has been suggested as an independent risk factor for progression-free survival (PFS) and overall survival (OS) in small cell lung cancer (SCLC). However, it is still unknown whether there is a linear relationship between the NLR and the risk of death in SCLC. The objective of this study is to provide further results. Patients and Methods: A retrospective cohort study was performed among a total of 251 participants with SCLC. Smooth curve fitting and piecewise Cox regression model were used to determine the linear relationship between NLR and mortality risk. A multivariable Cox regression model was used to estimate the effects of NLR on OS. Interaction and stratified analyses were conducted according to covariates. Results: The analysis indicated no significant nonlinear relationship or threshold effect between NLR and hazard of death. Multivariate analysis revealed that every unit increase in NLR was associated with a 10% increase in mortality risk. High NLR (>3.5) at baseline was associated with poor OS (hazard ratio [HR]=1.97, P=0.009). The difference in median OS duration between the high and low NLR groups was statistically significant (9.1 months vs 14.6 months, P=0.0067). Furthermore, interaction analysis identified the chemotherapy regimen to play an interactive role in the association between NLR and hazard of death. Conclusion: NLR was identified as an independent risk factor for OS in SCLC and the linear correlation was observed between them. Administration of etoposide plus cisplatin (EP) regimen in patients with low NLR resulted in better long-term outcome than that of etoposide plus carboplatin (EC) regimen, while administration of the EC regimen conferred longer OS than that of the EP regimen in patients with high NLR.

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Simple Peripheral Blood Cell Parameters to Predict Prognosis in Non-Small Cell Lung Cancer

Cited by 4 publications

References 24 publications

Prognostic Factors Determining Survival of Patients Operated for Non-Small Cell Lung Cancer with Consideration Given to Morphological Parameters of Blood

Prognostic Factors Determining Survival of Patients Operated for Non-Small Cell Lung Cancer with Consideration Given to Morphological Parameters of Blood

The Prognostic Significance of Preoperative Platelet-to-Lymphocyte and Neutrophil-to-Lymphocyte Ratios in Patients Operated for Non-Small Cell Lung Cancer

<p>A Retrospective Cohort Study on Pretreated Neutrophil-to-Lymphocyte Ratio and Prognosis of Small Cell Lung Cancer: Evidence of Effect Modification by Chemotherapy Regimen</p>

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