Simple, Three-Component, Highly Efficient Green Synthesis of Thiazolo[3,2-a]pyridine Derivatives Under Neat Conditions

Mekheimer, Ramadan Ahmed; Hilmy, Noha Mohamed; Hameed, Afaf Abdel; Dacrory, Sawsan; Sadek, Kamal Usef

doi:10.1080/00397911.2010.505700

Cited by 27 publications

(8 citation statements)

References 19 publications

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“…So, discovering new materials became an argent issue. [1][2][3] Biopolymers are promising candidates that can be fabricated into hydrophilic matrices and used for many applications due to their distinctive properties such as non-toxic, biodegradable, biocompatibility, and low cost. [4,5] Polysac-charide polymers have the excellent colloid-forming ability and high mechanical strength.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and antiviral activities with molecular docking study of chitosan/carrageenan@clove oil beads

Dacrory

Hashem

Kamel

2021

Biotechnology Journal

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Background: Biopolymers are promising candidates that can be fabricated into hydrophilic matrices and used for many applications due to their distinctive properties such as non-toxic, biodegradable, biocompatibility, and low cost. A promising composite of chitosan and carrageenan with self-crosslinking has been prepared. Methods and Results:In this study, a rigorous approach for an inexpensive and nontoxic combination of different amounts of clove oil with two polyelectrolytes including chitosan and carrageenan in the form of beads has been prepared. The structure and the surface morphology of the beads were investigated using FTIR, X-ray diffraction (XRD), and SEM. Moreover, antimicrobial, antiviral activity, and molecular docking were evaluated. Antibacterial results revealed that chitosan/carrageenan@clove oil beads have antimicrobial activity as well as chitosan/carrageenan without clove oil against Escherichia coli AATCC25922, Pseudomonas aeruginosa AATCC27853, Staphylococcus aureus ATCC25923, Bacillus subtilis AATCC6051, and Candida albicans ATCC90028. Furthermore, maximum non-toxic concentration (MNTC) of chitosan/carrageenan@clove oil beads was (31.25 μg ml -1 ) which exhibited promising antiviral activity against Herpes simplex virus-1 (HSV-1), and was significantly higher than chitosan/carrageenan without clove oil, where antiviral activity was 82.94% and 57.64%, respectively. Eventually, docking study and computational calculation have been used to show the reactivity of the molecules. Conclusions:The developed chitosan/carrageenan@clove oil beads have shown promising properties to be used as carriers of drug delivery, tissue engineering, and regenerative medicine.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial and antiviral activities with molecular docking study of chitosan/carrageenan@clove oil beads

Dacrory

Hashem

Kamel

2021

Biotechnology Journal

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“…Microwave is an eco-friendly method that not only reduces reaction time but also produces a considerable yield with high quality. Therefore it can be used in organic compounds synthesis [24][25][26]. In the present study, oxidation process has enhanced by using microwave irradiation in (DAC) synthesis to minimize the reaction time and GO is prepared via modified Hummer method.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity, DFT Calculations, and Molecular Docking of Dialdehyde Cellulose/Graphene Oxide Film Against Covid-19

Dacrory

2021

J Polym Environ

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Development of the oxidation process of cellulose has occurred to decrease the reaction time. Dialdehyd cellulose (DAC) has synthesized via periodate oxidation under microwave irradiation and Graphen oxide (GO) was synthesized by modified Hummer method. A new composite of DAC/GO has prepared from GO and DAC. The structure and morphology of DAC, GO and DAC/GO composite were evaluated via Fourier transform infrared spectroscopy, scanning electron microscopy and X-ray diffraction. Mechanical properties of DAC and DAC/GO were investigated. Additionally, the computational calculations of cellulose, DAC and GO by DFT/B3LYP/6-31G (d) basis sets were investigated. DAC/GO composite demonstrated specific antimicrobial activity against Gram-positive and Gram-negative bacteria. The molecular docking of DAC shows binding energy interaction (− 4.1, − 4.0, and − 4.0) Kcal/mol against microbial protein of Pseudomonas aeruginosa as Gram-negative bacteria PDB (2W7Q), and Staphylococcus aureus as Gram-positive bacteria PDB (1BQB) as well as Covid-19 PDB (7BZ5) respectively. DAC shows drug-like behavior when it is compared with binding energy interaction of Hydroxychloroquine against Covid-19, as a standard drug.

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“…[7][8][9][10] Among these heterocycles, pyridine derivatives, such as imidazopyridine, pyridopyrimidine, and thiazolopyridine derivatives have received considerable attention over the past years due to their diverse biological activities and clinical applications. 11,12 Imidazopyridine derivatives have shown a broad range of interesting biological activities, such as antifungal, antitumor, antiviral, antibacterial, anti-HIV, 13 antipyretic, analgesic, hypnoselective, anxioselective, anti-inammatory, anticonvulsant, antiulcer, immunomodulatory 14 activities; also pyridopyrimidine derivatives 15 are found to exhibit a broad spectrum of potent antibacterial, antiallergic, antimicrobial, 12 anti-inammatory, analgesic, 16,17 tyrosine kinase, calcium channel antagonists, 8,18 tuberculostatic, antileishmanial, antitumor, 19 antifolate, antihypertensive, hepatoprotective, 20 anticancer 21 properties; and thiazolopyridine derivatives are associated with a wide range of biological activities such as analgesic, antioxidant, 11 anticancer, 22 anti-inammatory, 23 antihypertensive, 24 antibacterial, and antifungal 25,26 properties.…”

Section: Introductionmentioning

confidence: 99%

Simple synthesis of new imidazopyridinone, pyridopyrimidinone, and thiazolopyridinone derivatives and optimization of reaction parameters using response surface methodology

Hosseini

Bayat

2019

RSC Adv.

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Simple, Three-Component, Highly Efficient Green Synthesis of Thiazolo[3,2-a]pyridine Derivatives Under Neat Conditions

Cited by 27 publications

References 19 publications

Antimicrobial and antiviral activities with molecular docking study of chitosan/carrageenan@clove oil beads

Antimicrobial and antiviral activities with molecular docking study of chitosan/carrageenan@clove oil beads

Antimicrobial Activity, DFT Calculations, and Molecular Docking of Dialdehyde Cellulose/Graphene Oxide Film Against Covid-19

Simple synthesis of new imidazopyridinone, pyridopyrimidinone, and thiazolopyridinone derivatives and optimization of reaction parameters using response surface methodology

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