Human Rights to Water and Sanitation (HRWS) have been consolidated as relevant frameworks to measure different levels of services. It is essential to move forward with specific initiatives that interpret the content of these human rights and operationalize them through specific metrics. However, some critical issues emerge in attempting this. Different approaches are proposed in this article to tackle this challenge: i) utilizing a participatory technique to discuss the relative importance of the normative criteria to define water and sanitation services, ii) defining a short list of key indicators to measure the different dimensions of HRWS, and iii) assessing the impact of different weighting systems in the constructing an aggregated index, which has been proposed as a useful tool to monitor water, sanitation, and hygiene (WASH) from a rights perspective. Two municipalities (in Mozambique and Nicaragua) were selected as initial case studies. The results suggest that there is a common understanding among the experts about prioritization of the HRWS criteria. Differences in the relative importance given to the HRWS criteria can be explained due to the particularities of the local context. Further, the research suggests that expert opinions may be partially conditioned by targets and indicators proposed at the international level. Although the influence of weighting techniques on aggregated measures and their utilization in the decision-making process are limited, this methodology has a great potential for adapting specific WASH metrics to different regional, national, and/or local contexts taking into account the HRWS normative content.