Objective: To determine the importance of Clinical Simulation on the performance of the nursing student in the clinical field and to explore the effects of this methodology for their subsequent performance in real contexts. Material and Method: Mixed study, cross-sectional, quantitative, associative and qualitative phenomenological approach. The unit of analysis were nursing students; the population corresponded to the universe of two fourth-year cohorts from the Universidad Austral de Chile, 106 participants for the quantitative approach and 10 for the qualitative one, selected by convenience sampling. The inclusion criteria for both approaches were having attended the 7th and 8th semester of the study program and having participated in subject simulation activities. Data collection was carried out using sociodemographic, Likerttype perception questionnaires (after face validity and clarity review) and in-depth interviews. Descriptive analyzes, parametric or non-parametric tests were carried out using SPSS v.15 software and qualitative analysis with phenomenological reduction. Researcher triangulation was performed to ensure data quality. Ethical rigor was based on the principles of Ezequiel Emanuel, informed consent and authorization of the university's Scientific Ethics Committee. Results: The methodology was valued in academic and personal areas, increasing security, abilities, skills and the presence of emotional memory, thus contributing to meaningful learning. Conclusions: Early curricular implementation of clinical simulation is important to enhance and optimize aspects related to the users of the system when interacting in real scenarios.