List-based simulated annealing (LBSA) algorithm is a novel simulated annealing algorithm where list-based cooling scheme is used to control the change of parameter temperature. Aiming to improve the efficiency of the LBSA algorithm for large-scale optimization problems, this paper proposes an enhanced LBSA (ELBSA) algorithm for solving large-scale traveling salesman problem (TSP). The ELBSA algorithm can drive more sampling at more suitable temperatures and from more promising neighborhoods. Specifically, heuristic augmented sampling strategy is used to ensure that more neighbors are from promising neighborhoods, systematic selection strategy is proposed to guarantee that each component of the current solution has a chance to be improved, and variable Markov chain length (VMCL), based on arithmetic sequence, is used to sample more neighbors at more suitable temperatures. Extensive experiments were performed to show the contribution of the heuristic augmented sampling strategy, and to verify the advantage of using systematic selection and VMCL. Comparative experiments, which were conducted on a wide range of large-scale TSP instances, show that the ELBSA algorithm is better than or competitive with most other state-of-the-art metaheuristics.INDEX TERMS Simulated annealing, traveling salesman problem, list-based cooling scheme, heuristic augmented sampling, systematic selection, variable Markov chain length.