In this paper the potential of an agile simulation proceeding in start-ups is described. The authors from the Chemnitz University of Technology worked together withHeliatek GmbH on the vision of a large scale organic solar film production. To accomplish the project goals, it was necessary to implement an agile simulation process, so that the right information could be gathered and integrated in the simulation environment. Due to this a high knowledge gain in the company and by the project participants could be reached, but also deficits of actual use of simulation tools in SME became visible. At the