Simulation of blood flow in a sudden expansion channel and a coronary artery

Wu, Wei‐Tao; Aubry, Nadine; Antaki, James F.; Massoudi, Mehrdad

doi:10.1016/j.cam.2020.112856

Cited by 19 publications

(7 citation statements)

References 53 publications

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“…Wu et al. (2020) reported that the recirculation zone after a sudden expansion arterial model with pulsatile inflow shows a reduced red blood cell concentration. They suggested that these recirculation zones may favour platelet accumulation.…”

Section: Introductionmentioning

confidence: 99%

Periodic flow features in a planar sudden expansion with pulsatile inflow velocity

Sarkar,

Roy

2024

J. Fluid Mech.

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Flow through sudden expansion finds its application in several engineering and biological processes. Though the stability of flow through steady sudden expansion has garnered much attention, little to none is given to the pulsatile flow through sudden expansion. Hence, in the present work we study the influence of inflow pulsatility on flow characteristics in a sudden expansion. The inflow velocity is a sinusoidal waveform that is modulated to encompass a wide range of amplitudes, ${{a}}$ , and reduced velocities, ${{U_{r}}}$ . We report four different modes, namely, synchronized growth of the recirculation region (at high ${{U_{r}}}$ ), necking and diffusion of the recirculation region (at moderately high ${{U_{r}}}$ ), splitting and convection of the recirculation region (at moderate ${{U_{r}}}$ ) and inverse growth of the recirculation region (at low ${{U_{r}}}$ ). In each mode, the symmetry-breaking critical Reynolds number is obtained through numerical experiments and compared with those of Floquet stability analysis. We found that diffusion and the convection mode of the recirculation region increases the stability of the flow while the inverse growth mode of the recirculation region decreases the same. The effect of the expansion ratio, ${{ER}}$ , is also explored, and we found that as ${{ER}}$ increases, the absolute stability of flow decreases, but relative stability between the modes remains similar. Finally, we explain the dynamics of the modes by using terms involving the vorticity transport equation.

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Section: Introductionmentioning

confidence: 99%

Periodic flow features in a planar sudden expansion with pulsatile inflow velocity

Sarkar,

Roy

2024

J. Fluid Mech.

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“…Higher exposure to Wall Shear Stresses were identified for increased angles of bifurcations [15]. A nonlinear rheological model is analyzed to study hemodynamics by Wu et al [16]. Simulations of a flow in a sudden expansion channel and the flow through an idealized curved coronary artery with pulsatile inlet velocity were done modelling blood as a suspension.…”

Section: Introductionmentioning

confidence: 99%

Numerical Analysis of Blood Flow through COVID-19 Infected Arteries

Krishnan¹,

Anantharaman²

2022

Molecular &Amp; Cellular Biomechanics

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Computational Fluid Dynamics has become relevant in the study of hemodynamics, where clinical results are challenging to obtain. This paper discusses a 2-Dimensional transient blood flow analysis through an arterial bifurcation for patients infected with the Coronavirus. The geometry considered is an arterial bifurcation with main stem diameter 3 mm and two outlets. The left outlet (smaller) has a diameter of 1.5 mm and the right outlet (larger), 2 mm. The length of the main stem, left branch and right branch are fixed at 35 mm, 20 mm and 25 mm respectively. Viscosity change that occurs in the blood leads to different parametrical changes in blood flow. The blood flow towards the smaller branch is significantly affected by the changed blood viscosity. Extended regions of high pressure and increased velocity towards the larger outlet are obtained. The Time Averaged Wall Shear Stress (TAWSS) for the corona affected artery is found to be 10.4114 Pa at a 90°angle of bifurcation as compared to 2.45002 Pa of the normal artery. For varying angles of bifurcation, an angle of 75°was found to have a maximum Time Averaged Wall Shear Stress of 2.46076 Pa and 10.42542 Pa for normal and corona affected artery, respectively.

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“…The more realistic multiphase model provides more information, such as, RBC volume fraction (VF), RBC velocity, viscosity of RBC and plasma [11]. Fewer studies incorporating a multiphase model while considering a real geometry model from an 8-year-old female patient with a moderate coarctation of aorta (CoA) [12], idealized geometric arteries [13][14][15] and pulsatile blood flow in coronary arteries [11,16] have been reported. Additionally, the mechanism of atherogenic disease progression is somewhat complex, so the hemodynamic indicators arising from multiphase modelling serve as bio markers for healthcare providers [17].…”

Section: Introductionmentioning

confidence: 99%

Two-Phase Non-Newtonian Pulsatile Blood Flow Simulations in a Rigid and Flexible Patient-Specific Left Coronary Artery (LCA) Exhibiting Multi-Stenosis

et al. 2021

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Coronary artery disease (CAD) is stated as one of the most common causes of death all over the world. This article explores the influence of multi stenosis in a flexible and rigid left coronary artery (LCA) model using a multiphase blood flow system which has not yet been studied. Two-way fluid–solid interaction (FSI) is employed to achieve flow within the flexible artery model. A realistic three-dimensional model of multi-stenosed LCA was reconstructed based on computerized tomography (CT) images. The fluid domain was solved using a finite volume-based commercial software (FLUENT 2020). The fluid (blood) and solid (wall) domains were fully coupled by using the ANSYS Fluid-Structure Interaction solver. The maximum pressure drops, and wall shear stress was determined across the sever stenosis (90% AS). The higher region of displacement occurs at the pre-stenosis area compared to the other area of the left coronary artery model. An increase in blood flow velocity across the restricted regions (stenosis) in the LCA was observed, whereas the recirculation zone at the post-stenosis and bifurcation regions was noted. An overestimation of hemodynamic descriptors for the rigid models was found as compared to the FSI models.

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Simulation of blood flow in a sudden expansion channel and a coronary artery

Cited by 19 publications

References 53 publications

Periodic flow features in a planar sudden expansion with pulsatile inflow velocity

Periodic flow features in a planar sudden expansion with pulsatile inflow velocity

Numerical Analysis of Blood Flow through COVID-19 Infected Arteries

Two-Phase Non-Newtonian Pulsatile Blood Flow Simulations in a Rigid and Flexible Patient-Specific Left Coronary Artery (LCA) Exhibiting Multi-Stenosis

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