Simulation of nano-biosensors based on conventional TCAD

Palestri, Pierpaolo; Sette, R.; Pittino, Federico; Saccon, Fernando A. M.; Esseni, D.; Selmi, L.

doi:10.1109/ulis.2013.6523495

Cited by 4 publications

(5 citation statements)

References 8 publications

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“…This paper extends previous investigations [32], [33], [34], [35], [36] aimed at developing a commercial TCAD based methodology for the simulation of electronic biosensors. In particular, we present a strategy to describe in TCAD the chemical reactions at the ISFET oxide/electrolyte interface, which were not addressed previously, but are the main contribution to the ISFET threshold voltage sensitivity to pH.…”

Section: Introductionsupporting

confidence: 62%

“…3), the thickness (t Stern ) is typically assumed equal to the cation's atomic radius [49] and the dielectric constant is set to a value such that the Stern layer capacitance is approximately 20 µF/cm 2 [30]. A reasonable choice of t Stern appreciably mitigates the inaccuracies due to the lack of specific models for steric effects [35], [34]. For all these reasons it is highly desirable to include the Stern layer in the ISFET model and adjust its capacitance to best fit the experiments.…”

Section: Model Of the Stern Layermentioning

confidence: 99%

See 1 more Smart Citation

A TCAD-Based Methodology to Model the Site-Binding Charge at ISFET/Electrolyte Interfaces

Bandiziol

Palestri

Pittino

et al. 2015

IEEE Trans. Electron Devices

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We propose a new approach to describe in commercial TCAD the chemical reactions that occur at dielectric/electrolyte interface and make the ion sensitive FET (ISFET) sensitive to pH. The accuracy of the proposed method is successfully verified against the available experimental data.\ud We demonstrate the usefulness of the method by performing, for the first time in a commercial TCAD environment, a full 2-D analysis of ISFET operation, and a comparison between threshold voltage and drain current differential sensitivities in the linear and saturation regimes. The method paves the way to accurate\ud and efficient ISFET modeling with standard TCAD tools

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Section: Introductionsupporting

confidence: 62%

Section: Model Of the Stern Layermentioning

confidence: 99%

A TCAD-Based Methodology to Model the Site-Binding Charge at ISFET/Electrolyte Interfaces

Bandiziol

Palestri

Pittino

et al. 2015

IEEE Trans. Electron Devices

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“…[533] Palestri et al presented a model for ISFET simulation in an electrolyte environment using SDevice TM , where they exploited the similarity between the transport equations of holes and electrons in semiconductors and the equations for charged ions in an electrolyte solution. [534] They demonstrated the model for double-gate ISFET pH sensors and sensing of charged biomolecules. The authors related the density of states for conduction and valence bands with the electrolytic concentrations of H + and OH − ions.…”

Section: Tcad Simulationmentioning

confidence: 99%

A comprehensive review of FET‐based pH sensors: materials, fabrication technologies, and modeling

Sinha

Pal

2021

Electrochemical Science Adv

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The demand for miniaturized point‐of‐care chemical/biochemical sensors has driven the development of field‐effect transistors (FETs) based pH sensors over the last 50 years. This paper aims to review the fabrication technologies, device structures, sensing film materials, and modeling techniques utilized for FET‐based pH sensors. We present the governing principles of potentiometric sensors, with major focus on the working principles of ion‐sensitive FETs (ISFETs). We extensively review different sensing film materials deposited by various techniques, which is critical to the sensing performance of ISFETs. The popular fabrication technologies have been presented, with special emphasis on state‐of‐the‐art silicon‐on‐insulator based technology, which can achieve high sensitivity by utilizing the dual‐gate effect. Furthermore, recent advancements in nano‐ISFETs has been elucidated. We also discuss the adoption of unmodified complementary metal‐oxide semiconductor (CMOS) ISFETs using standard CMOS processes, which has enabled the fabrication of integrated ISFET arrays, which are especially suited for ion‐imaging applications. Moreover, recent developments in extended‐gate FETs has been discussed, which have gained lot of attention due to their design flexibility and ease of fabrication, which is desirable for wearable sensing applications. In addition, recently there have been efforts to utilize nonsilicon channel materials for pH‐sensing application to obtain superior performance and various channel materials have been reviewed. Finally, we have extensively reviewed the ISFET device modeling and simulation techniques using various computer‐aided design tools, which aid in sensor design and characterization.

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“…B Ultra can detect kidney, liver, pelvic tumors such as endometrial cancer, pelvic cancer, ovarian cancer and the like. While X-ray can be screened for lung cancer [6][7][8]. Endoscopy for checking colon cancer, stomach cancer.…”

Section: Introductionmentioning

confidence: 99%

Research on Biological Snapshot Technology Based on Telemedicine Architecture

Musideke¹,

Mo²,

Qiang³

et al. 2016

Proceedings of the 2016 6th International Conference on Advanced Design and Manufacturing Engineering (ICADME 2016)

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Abstract. Cancer has always been possessing the highest mortality rate among major diseases, therefore, it is necessary and revolutionary for the research of the prevention of cancer. World Health Organization tells us that at least 30% of cancer is preventable and can be found in advance, so how to detect the cancer rapidly and sensitively has far-reaching significance. In this article, we used the UV spectrophotometric detection technology for human IgG protein and Raman spectroscopy to do a large number of experimental studies for qualitative and quantitative protein, obtained Raman spectra of characteristic protein and dyestuff, as well as UV spectrophotometer measured spectrum peak. We analyzed the experiment the get the conclusion, and established the database of the Raman spectra of proteins, so as to work in with telemedicine to improve current method of cancer's detection and diagnosis. Only with a complete test system program, will the rest of telemedicine have accurate and reliable data to support further depth promotion.

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Simulation of nano-biosensors based on conventional TCAD

Cited by 4 publications

References 8 publications

A TCAD-Based Methodology to Model the Site-Binding Charge at ISFET/Electrolyte Interfaces

A TCAD-Based Methodology to Model the Site-Binding Charge at ISFET/Electrolyte Interfaces

A comprehensive review of FET‐based pH sensors: materials, fabrication technologies, and modeling

Research on Biological Snapshot Technology Based on Telemedicine Architecture

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