Simulation of Radiation Damage to Neural Cells with the Geant4-DNA Toolkit

Bayarchimeg, Lkhagvaa; Batmunkh, Munkhbaatar; Belov, Oleg; Lkhagva, O.

doi:10.1051/epjconf/201817305005

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…In the case of CA1 pyramidal neuron (Fig 5a), it appears that more than 80 % of the total energy deposition occurred in dendrites, and energy in spines (8.3 %) is a little bit higher than in soma (7.9 %). In the case of DG granule cells, the largest portion of direct hits by energy deposition were obtained in dendrites and soma compared to spines as estimated previously [12,17]. For receptors, GABA A has received the largest amount of energy deposition with more than 1 keV for a single track of 600 MeV/u iron ion (see Fig 5b).…”

Section: Evaluation Of Energy Deposit In Possible Targets Of Hippocampussupporting

confidence: 59%

“…The detailed geometrical description of spines head and neck, and receptors as molecular targets has been described in detail elsewhere [12][13][14]. A full description of the neuron geometry implementation in Geant4 is already available in our previously published works and Geant4 application [15][16][17].…”

Section: Modeling Of Individual Neurons With Spines and Receptorsmentioning

confidence: 99%

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Monte Carlo track structure simulation in studies of biological effects induced by accelerated charged particles in the central nervous system

et al. 2019

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Simulating the biological damage induced by charged particles trajectories (tracks) in the central nervous system (CNS) at different levels of its organization (molecular, cellular, and tissue) is a challenge of modern radiobiology studies. According to the recent experimental studies at particle accelerators, the most radiation-sensitive area of the CNS is the hippocampus. In this regards, the development of measurement-based Monte Carlo simulation of radiation-induced alterations in the hippocampus is of great interest to understand the radiobiological effects on the CNS. The present work investigates the influence of charged particles on the hippocampal cells of the rat brain using the Geant4 Monte Carlo radiation transport code. The applied computer simulation provides a method to simulate physics processes and chemical reactions in the developed model of the rat hippocampus, which contains different types of neural cells - pyramidal cells, mature and immature granular cells, mossy cells, and neural stem cells. The distribution of stochastic energy depositions has been obtained and analyzed in critical structures of the hippocampal neurons after irradiation with 600 MeV/u iron particles. The computed energy deposition in irradiated hippocampal neurons following a track of iron ion suggests that most of the energy is accumulated by granular cells. The obtained quantities at the level of molecular targets also assume that NMDA and GABA receptors belong to the most probable targets in the irradiated neural cells.

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Section: Evaluation Of Energy Deposit In Possible Targets Of Hippocampussupporting

confidence: 59%

Section: Modeling Of Individual Neurons With Spines and Receptorsmentioning

confidence: 99%

Monte Carlo track structure simulation in studies of biological effects induced by accelerated charged particles in the central nervous system

et al. 2019

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“…In our previous modeling, we calculated the microscopic energy depositions and production of water radiolysis species in the vicinity of neuron structures using the Geant4/Geant4-DNA Monte Carlo radiation transport code [4][5][6][7]. In the present work, simplified models of a DG granule and a CA pyramidal cell were constructed from models of realistic neuron morphologies and adapted into standardized SWC file format.…”

Section: Simplified Neuron Models In the Monte Carlo Track-structure mentioning

confidence: 99%

Radiation Damage to Nervous System: Designing Optimal Models for Realistic Neuron Morphology in Hippocampus

et al. 2018

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Abstract. The present study is focused on the development of optimal models of neuron morphology for Monte Carlo microdosimetry simulations of initial radiation-induced events of heavy charged particles in the specific types of cells of the hippocampus, which is the most radiation-sensitive structure of the central nervous system. The neuron geometry and particles track structures were simulated by the Geant4/Geant4-DNA Monte Carlo toolkits. The calculations were made for beams of protons and heavy ions with different energies and doses corresponding to real fluxes of galactic cosmic rays. A simple compartmental model and a complex model with realistic morphology extracted from experimental data were constructed and compared. We estimated the distribution of the energy deposition events and the production of reactive chemical species within the developed models of CA3/CA1 pyramidal neurons and DG granule cells of the rat hippocampus under exposure to different particles with the same dose. Similar distributions of the energy deposition events and concentration of some oxidative radical species were obtained in both the simplified and realistic neuron models.

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Evaluation of Radiation-Induced Damage in Membrane Ion Channels and Synaptic Receptors

Bayarchimeg

Batmunkh

Bugay

et al. 2019

Phys. Part. Nuclei Lett.

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Simulation of Radiation Damage to Neural Cells with the Geant4-DNA Toolkit

Cited by 3 publications

References 9 publications

Monte Carlo track structure simulation in studies of biological effects induced by accelerated charged particles in the central nervous system

Monte Carlo track structure simulation in studies of biological effects induced by accelerated charged particles in the central nervous system

Radiation Damage to Nervous System: Designing Optimal Models for Realistic Neuron Morphology in Hippocampus

Evaluation of Radiation-Induced Damage in Membrane Ion Channels and Synaptic Receptors

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