Simulation of Separation Process with Laminar Flow in an Open Capillary

Harada, Makoto; Kido, Tomoo; Okada, Tetsuo

doi:10.2116/bunsekikagaku.54.1161

Cited by 3 publications

(1 citation statement)

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“…Therefore, it is important to understand the specific fluidic behavior, such as the diffusion and mixing of reagents that exist as laminar flows in the microchannels of microchips. [10][11][12][13] Recently, the observation of fluidic behavior of solutions in a polymer microchannel (polymethylmethacrylate; PMMA) was reported. 10 By monitoring the mixing and diffusion process of dye solutions with a commercial CCD camera attached to an optical microscope, the unique mixing process of liquids at the channel turnings with different shapes and roughnesses of the inner walls was observed.…”

Section: Introductionmentioning

confidence: 99%

Direct Observation of Dispersion and Mixing Processes in Microfluidic Systems

2008

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The diffusion phenomena, dispersion and mixing processes of the sample solute (Basic Blue 3 dye and KMnO4 aqueous solutions) were directly observed in laminar flow in glass microchannels. Quasi steady-state UV-visible absorption spectrometry was carried out using CCD camera images of the colored sample dispersion and mixing processes, and the absorbance change (DAbs) was discussed based on the dimensionless parameter, t which represents the flow time renormalized to the diffusion coefficient and the channel cross section. It was found that DAbs showed almost the same t dependence, even though the solutions and the microchannel sizes differed in laminar flow, if the microchannel fabrication method was the same. On the basis of this fundamental result, the total microchannel length required for the reaction of 2,3-diaminonaphthalene (DAN) and NO2 -at a flow rate of 2 mL min -1 was calculated, and the obtained value (~100 mm) showed very good agreement with our previous microchip research. It was concluded that both results were useful for designing the microchannel width, depth and length to control the chemical reaction time in recent microfluidic systems.

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Section: Introductionmentioning

confidence: 99%

Direct Observation of Dispersion and Mixing Processes in Microfluidic Systems

2008

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Hydrodynamic Chromatography in Narrow and Wide-Bores; Whether Radial Diffusion Is Essential or Not

Okada

2010

Journal of Liquid Chromatography & Related Technologies

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Molecular Characterization of Polymer through SEC and Other Several Methods

Takatori

2009

Journal of the Society of Rubber Industry, Japan

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Fractionation technique is very significant for the polymer analysis. Several methods were proposed, SEC(Size Exclusion Chromatography), FFF(Field Flow Fractionation), Electrophoresis, Hydrodynamic Chromatography, MTF (Molecular Topology Fractionation), and so on. In these methods SEC is the most general. This report reviews about concepts of separation mechanism, sources of analytical error, detectors, and analysis examples of SEC.

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Simulation of Separation Process with Laminar Flow in an Open Capillary

Cited by 3 publications

References 32 publications

Direct Observation of Dispersion and Mixing Processes in Microfluidic Systems

Direct Observation of Dispersion and Mixing Processes in Microfluidic Systems

Hydrodynamic Chromatography in Narrow and Wide-Bores; Whether Radial Diffusion Is Essential or Not

Molecular Characterization of Polymer through SEC and Other Several Methods

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