Simulation of spontaneous cardiovascular variability using PNEUMA

Иванова, О. В.; Khoo, Michael C. K.

doi:10.1109/iembs.2004.1404091

Cited by 8 publications

(7 citation statements)

References 16 publications

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“…Ivanova et al [14] developed a CP model with aortic baroreflex; however, the CVS model used was same that of Lu et al [17]. In general, except Beyar et al [12] model, no other model study was focused on MM simulation.…”

Section: Cp Model Formulationmentioning

confidence: 97%

“…To mimic practical MM in simulation, the P pl dynamics are formulated as Equation (14). MM dynamics has three different phases in general, namely onset, steady state and release ( Figure 10).…”

Section: MMmentioning

confidence: 99%

“…Mathematical modeling is one of the effective methodology to achieve the above-mentioned objectives. Only a few mathematical models have been developed to analyze intrapleural effects on CVS parameters in MM [12][13][14]. However, those models failed to address few of the following aspects; detailed anatomical representation of CVS and respiratory system (RPS), the various mechanisms affecting right-left heart interaction in entire circulation, turbulent and nonlinear behavior of heart valves and complete representation of baroreflex to modulate vital parameters such as heart rate (HR), cardiac contractility and peripheral resistance according to blood pressure variations [5,15].…”

Section: Introductionmentioning

confidence: 99%

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Cardiopulmonary model to study interaction hemodynamics in Muller maneuver

Hemalatha

Manivannan

2011

Int. J. Numer. Meth. Biomed. Engng.

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SUMMARYThe Muller maneuver (MM) is a frequently used physiological test in evaluating the cardiopulmonary (CP) interactions along with baroreflex functions in human. In spite of extensive experimental efforts, there is still ambiguity, controversy and disagreement in explaining different aspects of underlying mechanisms during MM. So far a complete comprehension of these mechanisms and the interactions among them is unavailable. In the present study, a CP model with detailed representation of cardiovascular, respiratory and baroreflex system is developed for the purpose of complete, continuous and simultaneous monitoring of all above three systems in MM to explain the underlying mechanisms. Our model incorporates the advantages of various models of all three systems reported separately in literature. Effective coupling is realized by intrapleural pressure between cardiovascular system and respiratory system Baroreflex regulation on cardiovascular system is achieved through vital cardiac parameters such as cardiac duration, contractility and peripheral resistance. Initially, the CP dynamics are tested qualitatively by simulating quiet breathing. Quiet breathing is simulated by perturbing intrapleural pressure in an exponential way from −3.7 to −5.5 mmHg. The quantitative analysis of CP interaction is studied by simulating MM in which strong intrapleural pressure variation is realized. The developed model can predict significant physiological events in individual system dynamics along with their interactions in quiet breathing condition as in literature data. In MM, simulated arterial pressure shows typical characteristic pattern. The quantitative analysis carried out with five different MM simulations shows an increase in LV afterload and decrease in RV preload, which lead to decrease in LV stroke volume. Mean arterial pressure is not significantly changing, however, the pulse pressure reduces significantly that stimulates baroreflex activation in MM. This suggests that arterial baroreflex responds mainly to pulsatile pressure changes compared to mean pressure changes. The right heart hemodynamics are more affected than left heart dynamics in MM. The model results are well supported by the experimental data reported in literature. Therefore, the model can be used as a tool to investigate the CP system dynamics to various normal and abnormal conditions.

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Section: Cp Model Formulationmentioning

confidence: 97%

Section: MMmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cardiopulmonary model to study interaction hemodynamics in Muller maneuver

Hemalatha

Manivannan

2011

Int. J. Numer. Meth. Biomed. Engng.

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“…Empirical and functional models have been proposed in the literature to describe various aspects of the cardiovascular system. Some of them also include the respiratory system interaction through an autonomic neural controller [7]. The cardiovascular system is structured in different intermediate processes (see Fig.…”

Section: Introductionmentioning

confidence: 99%

Cardiolab : A Virtual Laboratory for the analysis of Human circulatory system

Herrera

Mañanas

Costa‐Castelló

2009

2009 IEEE Conference on Emerging Technologies &Amp; Factory Automation

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One of the career areas included in the field of Biomedical Engineering is the application of engineering system analysis: physiological modelling, simulation and control. This paper describes a Virtual Laboratory for the analysis and the study of Human circulatory system. The Virtual Laboratory is based on the compilation of several mathematical models described in the literature. Presented application has been build using MAT-LAB/Simulink and EJS, so it combines good computation capabilities and it is completely interactive. The Virtual Laboratory is designed in order to understand the operation of the circulatory system under normal conditions, and to predict circulatory variables at different levels of stimuli and conditions.

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“…Some of them also include the respiratory system interaction through an autonomic neural controller [Ivanova and Khoo, 2004]. The cardiovascular system is structured in different intermediate processes (see Fig.…”

Section: Model Descriptionmentioning

confidence: 99%

EJS-Based Laboratory for Learning the Function of the Cardiovascular System

Mañanas

Costa‐Castelló

2010

IFAC Proceedings Volumes

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One of the career areas included in the field of Biomedical Engineering is the application of engineering system analysis: physiological modelling, simulation and control. This paper describes a Virtual Laboratory for the analysis and the study of Human circulatory system. The Virtual Laboratory is based on the compilation of several mathematical models described in the literature. Presented application has been build using MATLAB/Simulink and EJS, so it combines good computation capabilities and it is completely interactive. The Virtual Laboratory is designed in order to understand the operation of the circulatory system under normal conditions, and to predict circulatory variables at different levels of stimuli and conditions.

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Simulation of spontaneous cardiovascular variability using PNEUMA

Cited by 8 publications

References 16 publications

Cardiopulmonary model to study interaction hemodynamics in Muller maneuver

Cardiopulmonary model to study interaction hemodynamics in Muller maneuver

Cardiolab : A Virtual Laboratory for the analysis of Human circulatory system

EJS-Based Laboratory for Learning the Function of the Cardiovascular System

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