Simulation Studies of Neuronal Modulation Using Magneto-electric Nanoparticles for Astrocyte Stimulation

State of the Art and Current Challenges on Electroactive Biomaterials and Strategies for Neural Tissue Regeneration

“…[168] Computational studies are proposing the potential use of magnetoelectric materials for deep brain stimulation. [169,170] Superparamagnetic nanoparticles, as iron oxide-based nanoparticles, can convert alternating magnetic fields in localized heat through magnetothermal transduction. This ability allows the development of magnetothermal neural stimulation techniques.…”

“…Computational studies on the modulation of magnetoelectric nanoparticles to artificially stimulate the neural activity deep in the brain of a patient with Parkinson's disease have been presented. [ 169,170 ] The results suggested that 20 nm nanoparticles or 50 nm nanoparticles, both under an external 300 Oe magnetic field, could bring the pulsed sequences of electric fields of the patient to the levels compared to healthy people. With this, it was suggested that magnetoelectric nanoparticles can pave the way to develop new methods for noninvasive monitoring, prevention, and treatment of brain or other neural system.…”

Biomedical applications of multifunctional magnetoelectric nanoparticles

“…MENPs as core-shell structures, have been fabricated using various methods, including hydrothermal, 27,30,[34][35][36][37][38]49 and wet chemical 39,40,43 processes, and ball milling method. 40 Hydrothermal method is widely used for the fabrication of MENPs and produces high-crystalline inorganic nanomaterials in a closed batch reactor with metal precursors, surfactant, and solvents at high reaction temperatures (4100 1C) with above 1 atm pressure.…”

“…36 The risks and benefits of these approaches need to be assessed for effective use in humans. A subsequent computational study by the same group was performed to assess the use of MENPs to modulate the nervous system by stimulating astrocytes 35 (Fig. 4B and C).…”