Simulation study on sensitivity performance of a helmet-shaped brain PET scanner based on the Plug&amp;Imaging detector design

Antonecchia, Emanuele; Chu, Qian; Costanzo, Alfonso Di; Li, Z.; Wan, Lin; D’Ascenzo, N.; Xie, Qiangqiang

doi:10.1088/1748-0221/15/05/c05071

Cited by 5 publications

(5 citation statements)

References 28 publications

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“…The expected total sensitivity of the helmet is (8.46 ± 0.01)%, therefore approximately two times higher than the digital brain PET. A physical characterization of this novel device is reported elsewhere in this proceedings collection [36]. Here we show the expected count rate performance, which has an impact on the digital readout electronics.…”

Section: Plugandimaging Helmet Petmentioning

confidence: 60%

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Recent advances in digital Positron Emission Tomography

D’Ascenzo¹,

Antonecchia²,

Bender³

et al. 2020

J. Inst.

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A: Positron Emission Tomography (PET) is a non-disruptive functional imaging technique, which provides a high resolution and high-sensitivity measurement of the functional processes in biological systems. The recent developments in biology and radio-chemistry enabled PET to study an increasing number of functional processes, but became highly demanding in terms of sensitivity, spatial resolution, and adaptability to the variable size of the biological systems ranging from few millimeters up to several centimeters. In this paper we show how digital signal processing in PET plays an important role in the technological advancement. We report the recent results of digital signal processing methods based on the Multi Voltage Threshold technology, exploring the performances of a series of digital PET systems built upon this principle. We further describe developments of the MVT theory including space-pattern digital signal analysis and the related idea of the integration of the MVT technology within intelligent CMOS SiPM sensors for PET.

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Section: Plugandimaging Helmet Petmentioning

confidence: 60%

“…The experimental verification of the MVT readout at such high expected signal rates is currently under investigation, using the prototype of PET helmet shown in figure 6d, which has been designed following the estimation of the simulations reported here and in [36].…”

Section: Plugandimaging Helmet Petmentioning

confidence: 99%

Recent advances in digital Positron Emission Tomography

D’Ascenzo¹,

Antonecchia²,

Bender³

et al. 2020

J. Inst.

Self Cite

View full text Add to dashboard Cite

show abstract

“…The technology requirement of this prototype is conservative. We propose to use PET heads already established for other scanners (D'Ascenzo et al, 2018 ; Antonecchia et al, 2020 ). They consist of an array of 6 × 6 Lutetium Yttirium Oxyorthosilicate (LYSO) scintillators.…”

Section: Methodsmentioning

confidence: 99%

“…The method, radionuclide setting and source distribution come directly from the standard method (NEMA, 2008 ). For data collection, calculation and analysis we adopted the procedures described in Antonecchia et al ( 2020 ) for sensitivity measurements from simulated data. We simulated a point-like 22 Na source with a 0.3 mm radius positioned at the center of a PMMA cube with 10 mm side length.…”

Section: Methodsmentioning

confidence: 99%

Design Study of a Novel Positron Emission Tomography System for Plant Imaging

et al. 2022

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Positron Emission Tomography is a non-disruptive and high-sensitive digital imaging technique which allows to measure in-vivo and non invasively the changes of metabolic and transport mechanisms in plants. When it comes to the early assessment of stress-induced alterations of plant functions, plant PET has the potential of a major breakthrough. The development of dedicated plant PET systems faces a series of technological and experimental difficulties, which make conventional clinical and preclinical PET systems not fully suitable to agronomy. First, the functional and metabolic mechanisms of plants depend on environmental conditions, which can be controlled during the experiment if the scanner is transported into the growing chamber. Second, plants need to be imaged vertically, thus requiring a proper Field Of View. Third, the transverse Field of View needs to adapt to the different plant shapes, according to the species and the experimental protocols. In this paper, we perform a simulation study, proposing a novel design of dedicated plant PET scanners specifically conceived to address these agronomic issues. We estimate their expected sensitivity, count rate performance and spatial resolution, and we identify these specific features, which need to be investigated when realizing a plant PET scanner. Finally, we propose a novel approach to the measurement and verification of the performance of plant PET systems, including the design of dedicated plant phantoms, in order to provide a standard evaluation procedure for this emerging digital imaging agronomic technology.

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“…During the past few years we have reported the realization of related high bandwidth digital read-out electronics for radiation sensors [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30]. As a possible solution to the sampling-rate challenge, we have previously proposed a multi-voltage threshold (MVT) sampling method that takes samples of a pulse with respect to a set of reference voltages.…”

Section: Introductionmentioning

confidence: 99%

The JOINBON SiPM for the readout of LySO crystals: a Multi Voltage Threshold approach

D’Ascenzo

Wang²,

Zhang³

et al. 2020

J. Inst.

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The JOINBON Silicon Photomultiplier is a novel commercial silicon sensor for weak photon flux. In this paper we report a characterization of the sensor for the readout of LySO crystals with potential application to Positron Emission Tomography. We measured a energy resolution of approximately (13.50±0.03)% (FWHM) and a coincidence time resolution ranging between (215±3) ps for a 5 mm long crystal up to (290±2) ps for a 20 mm long crystal. Finally we tested the feasibility of the JOINBON SiPM to a Multi Voltage Threshold readout and we obtained a energy resolution compatible with the intrinsic system performance.

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Simulation study on sensitivity performance of a helmet-shaped brain PET scanner based on the Plug&Imaging detector design

Cited by 5 publications

References 28 publications

Recent advances in digital Positron Emission Tomography

Recent advances in digital Positron Emission Tomography

Design Study of a Novel Positron Emission Tomography System for Plant Imaging

The JOINBON SiPM for the readout of LySO crystals: a Multi Voltage Threshold approach

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