Simultaneous Analysis of d- and l-Serine in Cerebrospinal Fluid by Use of HPLC

Cerebrospinal Fluid Concentrations of Functionally Important Amino Acids and Metabolic Compounds in Patients with Mild Cognitive Impairment and Alzheimer’s Disease

“…This transition to a reactive state may be accompanied by a disruption of the cross talk normally occurring between astrocytes and neurons and so contribute to disease development [33] . Sethuraman et al [34] investigated CSF amino acids in patients with chronic pain and normal controls. Significant differences were found for D -and L -serine, glycine and citrulline.…”

“…These also include measurements of CSF concentrations of different amino acids and related metabolic compounds [34,37,38] . Especially CSF levels of glutamate have been studied in these populations [37,38] .…”

CSF Serine Enantiomers and Glycine in the Study of Neurologic and Psychiatric Disorders

“…Alterations in blood or CSF concentrations of Dand L-serine have been found in patients with schizophrenia (9,10,13,14 ), 3-phosphoglycerate-dehydrogenase deficiency, (11 ), and chronic pain (7 ). Furthermore, we reported increased glutamine:glutamate ratios in CSF of first-episode and drug-naive schizophrenic patients, suggesting that a dysfunction in the glutamate-glutamine cycle between neurons and glia may play a role in the pathophysiology of schizophrenia (15 ).…”

Two Mass-Spectrometric Techniques for Quantifying Serine Enantiomers and Glycine in Cerebrospinal Fluid: Potential Confounders and Age-Dependent Ranges

“…Recently, we reported that D-serine might be essential for human central nervous system development and provided the first example of human D-serine deficiency in patients with 3-phosphoglycerate dehydrogenase deficiency (7 ). Other studies have implicated altered D-serine concentrations in schizophrenia (8,9 ), amyotrophic lateral sclerosis (10 ), and nociception (11 ). Together, these studies imply that D-serine is important in human physiology and pathology.…”