The anticipated widespread use of the heavy-duty industrial manipulator (HDIM) makes it an important role in the field of modern industrial automation. Research on the attack of cyber-physical systems based on industrial manipulator vulnerabilities is booming, while there are few studies on the data logic and attack impact for HDIMs. This paper proposes a new cyber-physical attack mechanism named data logic attack mechanism on HDIMs, including network protocol data logic attack, system data integrity logic attack, and process logic attack. Meanwhile, data logic attack models for HDIMs and an attack impact analysis model are established. Besides, for the proposed data logic attack mechanism, a hardware-in-theloop cosimulation based on Simulink and Adams is carried out to demonstrate the impact of data logic attacks on the system integrity, availability, accuracy, and integrity. A test platform has also been established to test the attack mechanism's effectiveness. The results of cosimulation and test show the attack impact ranking and effectiveness of the attack mechanism. INDEX TERMS Industrial manipulator, data logic attack, impact analysis model, cosimulation.