Simultaneous anodization/anaphoretic electrodeposition synthesis of nano calcium phosphate/titanium oxide composite coatings assisted with chitosan oligosaccharide lactate

Pavlović, Marijana R. Pantović; Pavlović, Miroslav M.; Eraković, Sanja; Stevanović, Jasmina S.; Panić, Vladimir V.; Ignjatović, Nenad

doi:10.1016/j.matlet.2019.127121

Cited by 15 publications

(33 citation statements)

References 19 publications

(21 reference statements)

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“…Calcium phosphates (CP), amongst which amorphous calcium phosphate (ACP) and hydroxyapatite (HAp), along with TiO2 layers on Ti, have found vast applications in preventive and regenerative medicine due to their excellent biocompatibility, nontoxic properties and ability to participate in the normal metabolism of organisms. [1][2][3][4][5][6][7] New research on chitosan oligolactate (ChOL) coated HAp particles for drug delivery have indicated the advanced properties of this derivative. 4 The authors have already published the results about synthesis, physicochemical and bioactive properties of new ACP and ChOL-based multifunctional hybrid composite materials by novel in situ anodization/anaphoretic process.…”

Section: Introductionmentioning

confidence: 99%

“…4 The authors have already published the results about synthesis, physicochemical and bioactive properties of new ACP and ChOL-based multifunctional hybrid composite materials by novel in situ anodization/anaphoretic process. [1][2][3] However, in order to complete the research, there was need for in vitro cytotoxicity tests of the obtained materials, in order to elucidate their *Corresponding author: mpavlovic@tmf.bg.ac.rs; Phone: +381 11 3640 231 https://doi.org/10.2298/JSC210211024P O n L i n e F i r s t biomedical compatibility. This note aims to report the cytotoxicity analysis to round out the research on the novel materials.…”

Section: Introductionmentioning

confidence: 99%

“…EXPERIMENTAL ACP powder, as well as ACP/TiO2 and ACP/TiO2/ChOL composite coatings on Ti substrates using in situ anodization/anaphoretic deposition, are prepared as explained in previous work. 2 Briefly, deposition of these coatings was performed at constant voltage of 60 V for 180 s at 25 °C, starting from prepared suspensions. 2 Upon synthesis and prior to cytotoxicity tests, the appearance of the coatings were checked by FE-SEM, Tescan Mira 3 XMU FEG-SEM.…”

Section: Introductionmentioning

confidence: 99%

“…2 Briefly, deposition of these coatings was performed at constant voltage of 60 V for 180 s at 25 °C, starting from prepared suspensions. 2 Upon synthesis and prior to cytotoxicity tests, the appearance of the coatings were checked by FE-SEM, Tescan Mira 3 XMU FEG-SEM.…”

Section: Introductionmentioning

confidence: 99%

“…1 shows the FE-SEM images indicating that synthesized coatings cover Ti surface evenly, as expected from the previous research. 1,2…”

Section: Introductionmentioning

confidence: 99%

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Cytotoxicity of amorphous calcium phosphate multifunctional composite coatings on titanium obtained by in situ anodization/anaphoretic deposition

Pantovic-Pavlovic¹,

Pavlović²,

Kovacina³

et al. 2021

JSCS

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Cytotoxicity of amorphous calcium phosphate (ACP) and chitosan lactate (ChOL) multifunctional and hybrid composite coatings on MRC-5 human lung fibroblast cell line is elucidated. ACP/TiO2 and ACP/TiO2/ChOL are deposited onto Ti by novel in situ anodization/anaphoretic process at constant voltage. Cytotoxicity tests showed that there was no significant decrease in the survival of healthy MRC-5 cells eposed to composite samples without chitosan lactate, while there was an increase in the number of viable cells in the sample containing ChOL. The findings show that there is improved cell proliferation, differentiation and cell viability in the ChOL-containing sample, which makes ACP/TiO2/ChOL coating a good candidate for the applications in medicine and stomatology.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…1 shows the FE-SEM images indicating that synthesized coatings cover Ti surface evenly, as expected from the previous research. 1,2…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Cytotoxicity of amorphous calcium phosphate multifunctional composite coatings on titanium obtained by in situ anodization/anaphoretic deposition

Pantovic-Pavlovic¹,

Pavlović²,

Kovacina³

et al. 2021

JSCS

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Osteoblast and bacterial cell response on RGD peptide‐functionalized chitosan coatings electrophoretically deposited from different suspensions on Ti13Nb13Zr alloy

et al. 2023

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Metallic materials for long‐term load‐bearing implants still do not provide high antimicrobial activity while maintaining strong compatibility with bone cells. This study aimed to modify the surface of Ti13Nb13Zr alloy by electrophoretic deposition of a chitosan coating with a covalently attached Arg‐Gly‐Asp (RGD) peptide. The suspensions for coating deposition were prepared in two different ways either using hydroxyacetic acid or a carbon dioxide saturation process. The coatings were deposited using a voltage of 10 V for 1 min. The prepared coatings were examined using SEM, EDS, FTIR, and XPS techniques. In addition, the wettability of these surfaces, corrosion resistance, adhesion of the coatings to the metallic substrate, and their antimicrobial activity (E. coli, S. aureus) and cytocompatibility properties using the MTT and LDH assays were studied. The coatings produced tightly covered the metallic substrate. Spectroscopic studies confirmed that the peptide did not detach from the chitosan chain during electrophoretic deposition. All tested samples showed high corrosion resistance (corrosion current density measured in nA/cm2). The deposited coatings contributed to a significant increase in the antimicrobial activity of the samples against Gram‐positive and Gram‐negative bacteria (reduction in bacterial counts from 99% to, for CS‐RGD‐Acid and the S. aureus strain, total killing capacity). MTT and LDH results showed high compatibility with bone cells of the modified surfaces compared to the bare substrate (survival rates above 75% under indirect contact conditions and above 100% under direct contact conditions). However, the adhesion of the coatings was considered weak.

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Modified Titanium Surface with Nano Amorphous Calcium Phosphate@Chitosan Oligolactate as Ion Loading Platform with Multifunctional Properties for Potential Biomedical Application

Pantović Pavlović,

Ignjatović,

Gudić

et al. 2024

Ann Biomed Eng

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Simultaneous anodization/anaphoretic electrodeposition synthesis of nano calcium phosphate/titanium oxide composite coatings assisted with chitosan oligosaccharide lactate

Abstract: Ignjatović, Simultaneous anodization/anaphoretic electrodeposition synthesis of nano calcium phosphate/titanium oxide composite coatings assisted with chitosan oligosaccharide lactate, Materials Letters (2019), doi:

Cited by 15 publications

References 19 publications

Cytotoxicity of amorphous calcium phosphate multifunctional composite coatings on titanium obtained by in situ anodization/anaphoretic deposition

Cytotoxicity of amorphous calcium phosphate multifunctional composite coatings on titanium obtained by in situ anodization/anaphoretic deposition

Osteoblast and bacterial cell response on RGD peptide‐functionalized chitosan coatings electrophoretically deposited from different suspensions on Ti13Nb13Zr alloy

Modified Titanium Surface with Nano Amorphous Calcium Phosphate@Chitosan Oligolactate as Ion Loading Platform with Multifunctional Properties for Potential Biomedical Application

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