Simultaneous choroid plexus carcinoma and pilocytic astrocytoma in a pediatric patient

Abstract

<jats:p>Simultaneous primary brain tumors in pediatric patients without prior chemotherapy or radiotherapy, phacomatosis, or known familial history are a rare occurrence. The authors report the case of a 4-year-old boy with simultaneous choroid plexus carcinoma and pilocytic astrocytoma with features of oligodendroglioma. Magnetic resonance imaging studies revealed diffuse heterogeneously enhancing left intraventricular and posterior fossa tumors initially believed most consistent with multicentric choroid plexus carcinomas. A multiple staged resection was carried out for each tumor and gross-total resection was achieved. Upon gross inspection intraoperatively as well as postoperative histological analysis, 2 distinct simultaneous tumors were identified: choroid plexus carcinoma and pilocytic astrocytoma. To the authors' knowledge this is the first case report published identifying 2 distinct tumor types with similar radiological appearances in a pediatric patient with no prior history of radiotherapy, chemotherapy, or phacomatosis.</jats:p>

Intramedullary Pilomyxoid Astrocytoma with Intracerebral Metastasis Exhibiting Oligoden-Droglioma-Like Features

“…12,13 In pediatric patients, multicentric glioma are even rarer and limited to only few case reports. 14–16 A genetic predisposition such as neurofibromatosis or Li-Fraumeni syndrome in which brain tumors occur frequently is unlikely in this case, as an unremarkable family history and the absence of any clinical symptoms suspicious of these diseases argue against this possibility.…”

Synchronous Occurrence of Colloid Cyst With Intracranial Ossifying Fibromyxoid Tumor Masquerading as Meningioma

“…Gelabert et al reported the simultaneous occurrence of a frontal lobe astrocytoma and a colloid cyst of the third ventricle, both derived from displaced primitive neuroectodermal cells, suggesting the role of a single oncogenic factor in producing different tumors in the same individual [19]. Another hypothesis suggested by Karami et al explains that this phenomenon of simultaneous occurrence of histologically different tumors in different or same areas of the brain could be purely coincidental [20].…”

Surgical Treatment In a Case of Concomittant Frontal Gemistocytic Astrocytoma and Colloid Cyst

“…Santral sinir sisteminin farklı anatomik bölgelerinde kombine patolojilerin ortaya çıkması enderdir ve birbirine eşlik eden tümörlere bakıldığında, literatürde genellikle meningiomalar ve gliomaların birlikteliği yer almaktadır (5) . Bunlara kıyasla, ventriküler sistemde eşlik eden bir tümörün olması oldukça ender görülmektedir (6) .…”

“…Farklı histopatogenezdeki multipl beyin tümörlerinin ortaya çıkması tamamen rastlantısal olabilir, ama bu konuyu açıklamaya yönelik hipotezler de ortaya atılmıştır. Bunlardan ilki, "local cross-talk" teorisi olarak bilinen, önemli sayıda olgu sunumuyla ele alınan sav, bir tümörün lokal proliferasyon oluşturması ve diğer bir tümörü meydana getirmede irritan ajan olarak davranması olasıdır (6) . Yine, kolloid kist ve glioma birlikteliği olan olgularda, tümörlerin primitif nöroektodermal hücrelerden ve dolayısıyla multipotensiyel hücrelerden kaynaklanması nedeniyle farklı bölgelerde olmalarına rağmen, aynı onkojene maruz kalmaları sonucu gelişmiş olabileceği iddia edilmiştir (1) .…”