Simultaneous Detection and Evaluation of Four Subsets of CD4+ T Lymphocyte in Lesions and Peripheral Blood in Endometriosis

Takamura, Masashi; Koga, Kaori; Izumi, Gentaro; Hirata, Tetsuya; Harada, Miyuki; Hirota, Yasushi; Wada-Hiraike, Osamu; Fujii, Tomoyuki; Osuga, Yutaka

doi:10.1111/aji.12426

Cited by 72 publications

(63 citation statements)

References 47 publications

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“…Treg is another subset of helper T cells and they are known to maintain immunological tolerance . Many studies have shown that Treg are increased in the peritoneal cavity of endometriosis patients; however, two studies did not find a significant difference . In a mouse study, the inhibition of Treg induction (differentiation) reduced the number and weight of endometriotic lesions .…”

Section: Introductionmentioning

confidence: 92%

“…Furthermore, Th2 cytokines, such as IL‐4, IL‐10, and TSLP, have been shown to contribute to disease progression. Studies of peripheral blood, however, have revealed a higher Th1/Th2 cytokine ratio and Th1 cell frequency in endometriosis patients compared with controls. The discrepancy between the local and systemic Th1/Th2 balance remains unresolved.…”

Section: Introductionmentioning

confidence: 93%

“…72 In the endometriosis lesion, the frequency of Th1 cells is lower than in normal endometrium. 73 Furthermore, Th2 cytokines, such as IL-4, 74-76 IL-10, 77 and TSLP, 78 have been shown to contribute to disease progression. Studies of peripheral blood, however, have revealed a higher Th1/Th2 cytokine ratio 79 and Th1 cell frequency 73 in endometriosis patients compared with controls.…”

Section: T Cells Cd4+ T Cells Differentiate Into Helper T Cell Subsetsmentioning

confidence: 99%

“…It has been shown that cytokine secretion by peritoneal T cells is characteristic of Th2 in endometriosis tissue . In the endometriosis lesion, the frequency of Th1 cells is lower than in normal endometrium . Furthermore, Th2 cytokines, such as IL‐4, IL‐10, and TSLP, have been shown to contribute to disease progression.…”

Section: Introductionmentioning

confidence: 99%

“…Th17 are one of the helper T cell subsets and they are defined by their production of IL‐17a, a pro‐inflammatory cytokine. The frequency of Th17 in endometriosis lesions is higher than in that of the normal endometrium, and their high frequency in peritoneal fluid is associated with the increased severity of disease . IL‐17a is also described as an aggravator of endometriosis because it exacerbates inflammation and endometriotic cell proliferation .…”

Section: Introductionmentioning

confidence: 99%

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Involvement of immune cells in the pathogenesis of endometriosis

Izumi

Koga

Takamura

et al. 2018

J of Obstet and Gynaecol

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139

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Endometriosis is characterized by the implantation and growth of endometriotic tissues outside the uterus. It is widely accepted the theory that endometriosis is caused by the implantation of endometrial tissue from retrograde menstruation; however, retrograde menstruation occurs in almost all women and other factors are required for the establishment of endometriosis, such as cell survival, cell invasion, angiogenesis, and cell growth. Immune factors in the local environment may, therefore, contribute to the formation and progression of endometriosis. Current evidence supports the involvement of immune cells in the pathogenesis of endometriosis. Peritoneal neutrophils and macrophages secrete biochemical factors that help endometriotic cell growth and invasion, and angiogenesis. Peritoneal macrophages and NK cells in endometriosis have limited capability of eliminating endometrial cells in the peritoneal cavity. An imbalance of T cell subsets leads to aberrant cytokine secretions and inflammation that results in the growth of endometriosis lesions. It is still uncertain whether these immune cells have a role in the initial cause and/or stimulate actions that enhance disease; however, in either case, modulating the actions of these cells may prevent initiation or disease progression. Further studies are needed to deepen the understanding of the pathology of endometriosis and to develop novel management approaches of benefit to women suffering from this disease.

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Section: Introductionmentioning

confidence: 92%