Simultaneous determination of 2-furfuraldehyde, 5-hydroxymethylfurfuraldehyde and malonaldehyde in mixtures by derivative spectrophotometry and partial least-squares analysis

Espinos-Mansilla, A.; Peña, Arsenio Muñoz de la; Salinas, F.; Martínez-Galera, M.

doi:10.1016/0003-2670(93)85049-p

Cited by 59 publications

(18 citation statements)

References 15 publications

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“…The absorbance of the colorants-gel system showed a maximum value when the concentration of NaCl and KClO 4 was 2.0 3 10 22 mol l 21 and decreased by about 12% when concentrations were higher than 10 21 mol l 21 .…”

Section: Other Experimental Conditionsmentioning

confidence: 92%

“…The concentration of each colorant was varied between 20.0 and 500.0 ng ml 21 , avoiding any correlation of concentrations among the different samples so as not to cause underfitting in the PLS model. Table 1 summarizes the concentrations of each sample of the set.…”

Section: Application Of the Pls-2 Modelmentioning

confidence: 99%

“…21 In all instances the analysis of these compounds was accomplished in solution; however, PLS has not been applied to spectrophotometric analysis of these chemicals in the solid-phase.…”

mentioning

confidence: 99%

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Simultaneous Determination of the Colorants Sunset Yellow FCF and Quinoline Yellow by Solid-phase Spectrophotometry Using Partial Least Squares Multivariate Calibration

Capitán-Vallvey¹,

Fernández²,

Orbe³

et al. 1997

Analyst

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A method for the simultaneous determination of the colorants Sunset Yellow FCF and Quinoline Yellow using solid-phase spectrophotometry is proposed. The colorants were isolated in Sephadex DEAE A-25 gel at pH 5.0, the gel-colorants system was packed in a 1 mm silica cell and spectra were recorded between 400 and 600 nm against a blank. Statistical results were obtained by partial least squares (PLS) multivariate calibration. The optimized matrix by using the PLS-2 method enables the determination of the colorants in artificial mixtures and commercial soft drinks.

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Section: Other Experimental Conditionsmentioning

confidence: 92%

Section: Application Of the Pls-2 Modelmentioning

confidence: 99%

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Simultaneous Determination of the Colorants Sunset Yellow FCF and Quinoline Yellow by Solid-phase Spectrophotometry Using Partial Least Squares Multivariate Calibration

Capitán-Vallvey¹,

Fernández²,

Orbe³

et al. 1997

Analyst

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“…The f-statistic was used to make the significant determination. The maximum number of factors used to calculate the optimum PRESS was selected to be 6 (half the number of samples+1) [44] and the optimum number of factors used for building PLS and PCR models was found to be 2 (Table 5 and Fig. 3).…”

Section: Partial Least Squares and Principle Component Regressionmentioning

confidence: 99%

Simultaneous determination of domperidone and cinnarizine in a binary mixture using derivative spectrophotometry, partial least squares and principle component regression calibration

et al. 2003

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This work is concerned with the simultaneous determination of domperidone maleate (DOM) and cinnarizine (CINN) in a binary mixture form, without previous separation, by two different techniques. The first method is the application of derivative spectrophotometry where the linearity range and percentage recoveries for DOM and CINN were 2.5-30 micro g mL(-1), 5-25 micro g mL(-1) and 100.06+/-1.157, 99.93+/-1.377, respectively. The second method depends on the application of partial least squares (PLS) and principle component regression (PCR) models. A training set consisting of 10 mixtures containing 5-20 micro g mL(-1) for each component was used for the construction of the PCR and PLS models. These models were used after their validation for the prediction of the concentration of DOM and CINN in their mixtures. The proposed procedures were successfully applied for the simultaneous determination of both drugs in laboratory prepared mixtures and in commercial tablet preparations. The validity of the proposed methods was assessed by applying the standard addition technique where the percentage recovery of the added standard was found to be 99.98+/-0.297 and 99.84+/-0.700 for DOM and CINN, respectively, using the derivative spectrophotometric method and 100.29+/-0.398 and 100.11+/-0.363 for DOM and CINN, respectively, using the PLS and PCR methods. The proposed procedures are rapid, simple, require no preliminary separation steps and can be used for routine analysis of both drugs in quality control laboratories.

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“…The application of multivariate calibration methods to both spectral or electrochemical data in the biomedical and pharmaceutical fields has acquired a routine nature [1,2,3,4,5,6,7,8]. Partial least-squares (PLS) has become the de facto standard for multivariate calibration because of the quality of the obtained calibration models, the ease of its implementation and the availability of software [9].…”

Section: Introductionmentioning

confidence: 99%

Complementary use of partial least-squares and artificial neural networks for the non-linear spectrophotometric analysis of pharmaceutical samples

Goicoechea

Collado

Satuf

et al. 2002

Analytical and Bioanalytical Chemistry

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The complementary use of partial least-squares (PLS) multivariate calibration and artificial neural networks (ANNs) for the simultaneous spectrophotometric determination of three active components in a pharmaceutical formulation has been explored. The presence of non-linearities caused by chemical interactions was confirmed by a recently discussed methodology based on Mallows augmented partial residual plots. Ternary mixtures of chlorpheniramine, naphazoline and dexamethasone in a matrix of excipients have been resolved by using PLS for the two major analytes (chlorpheniramine and naphazoline) and ANNs for the minor one (dexamethasone). Notwithstanding the large number of constituents, their high degree of spectral overlap and the occurrence of non-linearities, rapid and simultaneous analysis has been achieved, with reasonably good accuracy and precision. No extraction procedures using non-aqueous solvents are required.

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Simultaneous determination of 2-furfuraldehyde, 5-hydroxymethylfurfuraldehyde and malonaldehyde in mixtures by derivative spectrophotometry and partial least-squares analysis

Cited by 59 publications

References 15 publications

Simultaneous Determination of the Colorants Sunset Yellow FCF and Quinoline Yellow by Solid-phase Spectrophotometry Using Partial Least Squares Multivariate Calibration

Simultaneous Determination of the Colorants Sunset Yellow FCF and Quinoline Yellow by Solid-phase Spectrophotometry Using Partial Least Squares Multivariate Calibration

Simultaneous determination of domperidone and cinnarizine in a binary mixture using derivative spectrophotometry, partial least squares and principle component regression calibration

Complementary use of partial least-squares and artificial neural networks for the non-linear spectrophotometric analysis of pharmaceutical samples

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