Simultaneous Determination of Acetaminophen and Hydrocodone Bitartrate in Solid Dosage Forms by HPLC

Fatmi, Aqeel A.; Williams, Gregory V.

doi:10.1080/01483918708068927

Cited by 6 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several reversed-phase HPLC methods have been published for the determination of hydrocodone in solid [7,8] and liquid [9] dosage formulations. Broglé at al.…”

Section: Introductionmentioning

confidence: 99%

Determination of 6-oxo-morphinans, as the oximes, by difference circular dichroism spectroscopy

Szentesi

Gergely

Horváth

et al. 2002

Analytical and Bioanalytical Chemistry

View full text Add to dashboard Cite

A negative Cotton effect is observed in the circular dichroism (CD) spectra of 6-oxo-morphinans in the wavelength range of n-pi* electron transitions. 6-oxo-Morphinans can be transformed into oxime derivatives with hydroxylamine and after oxime formation the CD spectra are significantly different. Oxime formation was monitored by CD and by HPLC. It was established that under the experimental conditions used oxime formation was complete within 90 min. The method suggested for the determination of 6-oxo-morphinans is based on the considerable differences between the ellipticities before and after the oxime formation. The ellipticity difference varies linearly with concentration in the range 2 x 10(-5)-5 x 10(-4) mol L(-1) for the three 6-oxo-morphinans examined (oxycodone, hydrocodone, and 14-hydroxycodeinone). For hydrocodone the dependence is also linear in a lower concentration range (5 x 10(-6)-10(-4) mol L(-1)). The new difference CD spectroscopic method can be applied to the selective determination of 6-oxo-morphinans in bulk and dosage forms.

show abstract

“…Several reversed-phase HPLC methods have been published for the determination of hydrocodone in solid [7,8] and liquid [9] dosage formulations. Broglé at al.…”

Section: Introductionmentioning

confidence: 99%