Simultaneous determination of amantadine, rimantadine, and memantine in processed products, chicken tissues, and eggs by liquid chromatography with tandem mass spectrometry

Tsuruoka, Yumi; Nakajima, Takayuki; Kanda, Manabu; Hayashi, Hiroshi; Matsushima, Yoko; Yoshikawa, Souichi; Nagata, Marie; Koike, Hiroshi; Nagano, Chieko; Sekimura, Kotaro; Hashimoto, Tsuneo; Takano, Ichiro; Shindo, Tetsuya

doi:10.1016/j.jchromb.2017.01.014

Cited by 38 publications

(12 citation statements)

References 28 publications

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“…Amantadine and rimantadine can prevent the virus from shelling in the cytoplasm, thus inhibiting the transmission of virus offspring [118]. Although developed for many years, it has been reported frequently that they are ineffective in clinical treatment due to drug resistance of almost all currently circulating IAVs [119]. Furthermore, they have a relatively large side effect on the human central nervous system, thus are no longer recommended by WHO as the first choice of anti-influenza drugs for the treatment or prophylaxis of influenza [118].…”

Section: Treatmentmentioning

confidence: 99%

Comparative review of respiratory diseases caused by coronaviruses and influenza A viruses during epidemic season

Jiang

Yao

Zhao

et al. 2020

Microbes and Infection

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to sweep the world, causing infection of millions and death of hundreds of thousands. The respiratory disease that it caused, COVID-19 (stands for coronavirus disease in 2019), has similar clinical symptoms with other two CoV diseases, severe acute respiratory syndrome and Middle East respiratory syndrome (SARS and MERS), of which causative viruses are SARS-CoV and MERS-CoV, respectively. These three CoVs resulting diseases also share many clinical symptoms with other respiratory diseases caused by influenza A viruses (IAVs). Since both CoVs and IAVs are general pathogens responsible for seasonal cold, in the next few months, during the changing of seasons, clinicians and public heath may have to distinguish COVID-19 pneumonia from other kinds of viral pneumonia. This is a discussion and comparison of the virus structures, transmission characteristics, clinical symptoms, diagnosis, pathological changes, treatment and prevention of the two kinds of viruses, CoVs and IAVs. It hopes to provide information for practitioners in the medical field during the epidemic season.

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Section: Treatmentmentioning

confidence: 99%

Comparative review of respiratory diseases caused by coronaviruses and influenza A viruses during epidemic season

Jiang

Yao

Zhao

et al. 2020

Microbes and Infection

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“…There are many instrument-based methods and immunoassays for the detection of AMD or RVB, such as liquid chromatography-tandem mass spectrometry (LC-MS/ MS) (Tsuruoka et al, 2017;Wu et al, 2016), high-performance liquid chromatography-tandem mass spectrometry method (HPLC-MS/MS) (You et al, 2017), and enzyme-linked immunosorbent assay (ELISA) (Wang et al, 2017(Wang et al, , 2018. Up to now, all of the simultaneous detection assays of AMD and RVB are instrumental analysis methods (Table S3).…”

Section: Introductionmentioning

confidence: 99%

Multi-wavelength fluorescence polarization immunoassays for simultaneous detection of amantadine and ribavirin in chicken and human serum

Guo

Liu

Zhang

et al. 2021

Food and Agricultural Immunology

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In this study, a homologous multi-wavelength fluorescence polarization immunoassays (MWFPIA) for rapid determination of amantadine (AMD) and ribavirin (RVB) simultaneously was established. The MWFPIA could quantify AMD and RVB concentration simultaneously in 1 min. After optimisation, longwavelength tracers AEDA-AF647 with monoclonal antibody (Mab) 1A12 and RVB-CP-EDF with polyclonal antibody (Pab) G412 were chosen for the development of MWFPIA. The limit of detections (LODs) of AMD and RVB were 1.7 and 1.0 μg/kg in chickens, and 17.6 and 10.4 μg/L in human serum, respectively. Recoveries of AMD and RVB in chickens were 61.2-94.9% and 87.3-90.2%, respectively with coefficient of variations (CVs) lower than 16.7%. For human serum, recoveries were 60.2-84.3% and 63.5-74.2% for AMD and RVB, respectively, and CVs was lower than 15.3%. The results indicated that the MWFPIA could be used for the monitoring of antiviral drugs with short analysis time, great accuracy and high throughput.

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“…Because of these potential risks, AMA has been banned in livestock farming by USA and China since 2005 [ 6 , 7 ]. So far, lots of assays have been reported for the detection of AMA, including near-infrared spectroscopy [ 8 , 9 ], HPLC-MS/GC-MS [ 6 , 10 , 11 , 12 , 13 , 14 , 15 , 16 ], micellar electrokinetic chromatography (MEKC) [ 17 ], capillary electrophoresis [ 18 , 19 ], and potentiometry [ 20 , 21 ]. However, those methods normally require complicated, expensive equipment and labor-intensive sample preparation procedures.…”

Section: Introductionmentioning

confidence: 99%

A Highly Selective and Strong Anti-Interference Host-Guest Complex as Fluorescent Probe for Detection of Amantadine by Indicator Displacement Assay

et al. 2018

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Amantadine (AMA) and its derivatives are illicit veterinary drugs that are hard to detect at very low concentrations. Developing a fast, simple and highly sensitive method for the detection of AMA is highly in demand. Here, we designed an anthracyclic compound (ABAM) that binds to a cucurbit[7]uril (CB[7]) host with a high association constant of up to 8.7 × 108 M−1. The host-guest complex was then used as a fluorescent probe for the detection of AMA. Competition by AMA for occupying the cavity of CB[7] allows ABAM to release from the CB[7]-ABAM complex, causing significant fluorescence quenching of ABAM (indicator displacement assay, IDA). The linear range of the method is from 0.000188 to 0.375 μg/mL, and the detection limit can be as low as 6.5 × 10−5 μg/mL (0.35 nM). Most importantly, due to the high binding affinity between CB[7] and ABAM, this fluorescence host-guest system shows great anti-interference capacity. Thus, we are able to accurately determine the concentration of AMA in various samples, including pharmaceutical formulations.

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Simultaneous determination of amantadine, rimantadine, and memantine in processed products, chicken tissues, and eggs by liquid chromatography with tandem mass spectrometry

Cited by 38 publications

References 28 publications

Comparative review of respiratory diseases caused by coronaviruses and influenza A viruses during epidemic season

Comparative review of respiratory diseases caused by coronaviruses and influenza A viruses during epidemic season

Multi-wavelength fluorescence polarization immunoassays for simultaneous detection of amantadine and ribavirin in chicken and human serum

A Highly Selective and Strong Anti-Interference Host-Guest Complex as Fluorescent Probe for Detection of Amantadine by Indicator Displacement Assay

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