Simultaneous Determination of Five Nonsteroidal Anti-Inflammatory Drugs and Two Glucocorticoids in Adulterated Traditional Herbal Medicines for the Treatment of Rheumatism

Zhang, C. Y.; Chang, Ding; Chen, S. L.

doi:10.1080/00032719.2010.526268

Cited by 8 publications

(2 citation statements)

References 29 publications

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“…To realize the modernization of CHMs, the raw materials must first be certified, which requires a high-throughput screening method to identify and collect their chemical information. [36][37][38][39] Raman spectroscopy has the characteristics of high chemical specificity and rapid analysis. So far, various Raman techniques have been successfully applied in the qualitative and quantitative analyses of CHM raw materials to establish the corresponding Raman spectrum database, such as distinguishing geographical origins of Ginseng, 16 Lycium barbarum 40 and Radix astragali, 41 probing the protein structures of various yam species 20 and collecting the chemical fingerprint information of Gynostemma pentaphyllum, 42 Radix sanguisorbae 43 and Aconiti kusnezoffii and cinnabar.…”

Section: Raw Materials Identificationmentioning

confidence: 99%

Surface-enhanced Raman spectroscopy as a powerful method for the analysis of Chinese herbal medicines

Xu,

Song,

et al. 2024

Analyst

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Section: Raw Materials Identificationmentioning

confidence: 99%

Surface-enhanced Raman spectroscopy as a powerful method for the analysis of Chinese herbal medicines

Xu,

Song,

et al. 2024

Analyst

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“…As reported in several studies, NSAIDs and acetaminophen have been found to be illegally adulterated with other pharmaceuticals such as corticosteroids. 6,7,22,23 Therefore, screening using high-resolution MS is essential for accurately identifying NSAIDs, acetaminophen, and unknown compounds illegally adulterated with them.…”

mentioning

confidence: 99%

Liquid chromatography–quadrupole orbitrap and liquid chromatography–tandem mass spectrometry system for rapid identification and quantitation of thirty nonsteroidal anti‐inflammatory drugs and acetaminophen in illegal products

Park

Ham

Yang

et al. 2023

Rapid Comm Mass Spectrometry

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Rationale: As the public interest in healthcare increases, illegal dietary supplements, foods, and drugs containing unauthorized pharmaceutical ingredients, including nonsteroidal anti-inflammatory drugs (NSAIDs) and acetaminophen, have been identified. Excessive and unintentional consumption is toxic to the gastrointestinal tract, kidneys, and liver; therefore, these pharmaceuticals must be monitored using analytical methods.Methods: A rapid and reliable analysis system involving liquid chromatographyquadrupole orbitrap mass spectrometry (LC-Q-Orbitrap/MS) and liquid chromatography-tandem mass spectrometry (LC/MS/MS) was established and validated to identify and quantify 30 NSAIDs and acetaminophen. In addition, we obtained the MS 2 spectrum for each component with the proposed structure of the fragment ions. Results:The analytical method was applied to 505 samples of illicitly distributed dietary supplements, foods, and pharmaceuticals. Non-steroidal analgesics were detected in 126 samples. Carbamazepine (42.9%) and diclofenac (30.2%) were the most detected components in the samples; other pharmaceutical adulterants were also detected in some cases. Additionally, we present the identification of an unknown component, dexamethasone (799 μg/g), using LC-Q-Orbitrap/MS in a sample containing the unknown component with meloxicam (15.4 mg/g).Conclusions: The developed analysis system, consisting of qualitative analysis using LC-Q-Orbitrap/MS and quantitative analysis using LC/MS/MS, can rapidly and accurately identify and quantify NSAIDs and acetaminophen while also identifying non-analytical components. | INTRODUCTIONWith the increasing consumption of dietary supplements, their sales are estimated to exceed $30 billion in the United States and $100 billion worldwide. 2 People who consume dietary supplements, foods, or herbal medicines to manage health conditions such as osteoarthritis believe that these products do not pose a significant health threat because they do not contain synthetic pharmaceuticals. 1 However, some unscrupulous dietary supplement manufacturers often intentionally mix and market synthetic pharmaceutical Hyoung-Joon Park and Hyeon Joo Ham contributed equally to this work.

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Capillary electrophoretic methods for the screening and determination of pharmacologic adulterants in herbal‐based pharmaceutical formulations

2014

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This review aims to describe the CE methods utilized for the determination of adulterants in herbal-based formulations marketed for different therapeutic purposes. The CE methods for screening and determination of pharmacologic adulterants are reviewed on the basis of the CE techniques and their detection methods. CZE and MEKC methods coupled to optical (UV), capacitively coupled contactless conductivity, and MS detection modes are discussed and reviewed. Worldwide adulteration cases related to pharmaceutical formulations containing herbs as the main active products are presented covering all the works published in the last four decades.

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Simultaneous Determination of Five Nonsteroidal Anti-Inflammatory Drugs and Two Glucocorticoids in Adulterated Traditional Herbal Medicines for the Treatment of Rheumatism

Cited by 8 publications

References 29 publications

Surface-enhanced Raman spectroscopy as a powerful method for the analysis of Chinese herbal medicines

Surface-enhanced Raman spectroscopy as a powerful method for the analysis of Chinese herbal medicines

Liquid chromatography–quadrupole orbitrap and liquid chromatography–tandem mass spectrometry system for rapid identification and quantitation of thirty nonsteroidal anti‐inflammatory drugs and acetaminophen in illegal products

Capillary electrophoretic methods for the screening and determination of pharmacologic adulterants in herbal‐based pharmaceutical formulations

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