Simultaneous determination of fluoroquinolone, sulfonamide, and trimethoprim antibiotics in wastewater using tandem solid phase extraction and liquid chromatography–electrospray mass spectrometry

Renew, Jay; Huang, Ching-Hua

doi:10.1016/j.chroma.2004.05.056

Cited by 323 publications

(184 citation statements)

References 32 publications

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“…However, other types of sorbents were utilized as well as can be seen in Table 1. In three studies the tandem of two SPE cartridges was used to achieve better clean-up step and thus high recoveries [19,42,43]. Washing step was referred in majority of studies as is suitable for extraction of analytes from the complex matrices as wastewaters.…”

Section: Multiresidual Methodsmentioning

confidence: 99%

“…Sulphuric acid was employed for the pH adjustment of the sample to pH 2.0 for the determination of erythromycin (ERY), SMX and TMP [18]. One method referred the addition of Na 2 S 2 O 3 as a quenching agent to consume residual chlorine contained in the samples of wastewater effluents [19].…”

Section: Sampling Storage and Stabilitymentioning

confidence: 99%

“…One study refers a salt addition step during the determination of FQs, SAs and TMP in wastewaters [19]. In this case, an addition of 0.1 M NaCl improved antibiotic extraction efficiency, particularly for SAs and TMP.…”

Section: Sample Pre-treatment and Extraction Proceduresmentioning

confidence: 99%

“…It is due to the following elution step when impurities can be eluted together with desirable analytes. The elution of cartridges is usually done by organic solvents such as MeOH (in majority of studies), acidified MeOH [4,19] or acetonitrile (ACN) [44][45][46]. The elution of cationexchange cartridges is done by the mixture of MeOH and ammonia according to the specific sorbent and guidelines from manufacturer.…”

Section: Sample Pre-treatment and Extraction Proceduresmentioning

confidence: 99%

See 3 more Smart Citations

An overview of analytical methodologies for the determination of antibiotics in environmental waters

Seifrtová¹,

Nováková²,

Lino³

et al. 2009

Analytica Chimica Acta

322

170

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a b s t r a c tThe widespread occurrence of antibiotics as contaminants in the aquatic environment has increased attention in the last years. The concern over the release of antibiotics into the environment is related primarily to the potential for the development of antimicrobial resistance among microorganisms. This article presents an overview of analytical methodologies for the determination of quinolone (Qs) and fluoroquinolone (FQs), macrolide (MLs), tetracycline (TCs), sulfonamide (SAs) antibiotics and trimethoprim (TMP) in different environmental waters. The analysis of these antibiotics has usually been carried out by high-performance liquid chromatography (HPLC) coupled to mass spectrometry (MS) or tandem mass spectrometry (MS/MS) and to a lesser extent by ultraviolet (UV) or fluorescence detection (FD). A very important step before LC analysis is sample preparation and extraction leading to elimination of interferences and prevention of matrix effect and preconcentration of target analytes.

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Section: Multiresidual Methodsmentioning

confidence: 99%

Section: Sampling Storage and Stabilitymentioning

confidence: 99%

Section: Sample Pre-treatment and Extraction Proceduresmentioning

confidence: 99%

Section: Sample Pre-treatment and Extraction Proceduresmentioning

confidence: 99%

See 2 more Smart Citations

An overview of analytical methodologies for the determination of antibiotics in environmental waters

Seifrtová¹,

Nováková²,

Lino³

et al. 2009

Analytica Chimica Acta

322

170

View full text Add to dashboard Cite

show abstract

“…[38][39][40]44 This is critical for some applications such as pharmacokinetic studies that handle a large number of samples. Theron et al 44 described a method for quantification of EFZ in human saliva with a LLOQ of 6.11 ng mL -1 , but with a long analysis time 8.5 min.…”

Section: Discussionmentioning

confidence: 99%

A sensitive and robust lc-ms/ms method with monolithic column and electrospray ionization for the quantitation of efavirenz in human plasma: application to a bioequivalence study

Bedor¹,

Filho²,

Ramos³

et al. 2011

Quím. Nova

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Recebido em 12/7/10; aceito em 17/12/10; publicado na web em 25/3/11An LC-MS/MS method has been developed for the determination of efavirenz (EFZ) in human plasma using hydrochlorothiazide as internal standard (I.S.). An ESI negative mode with multiple reaction-monitoring was used monitoring the transitions m/z 313.88→69.24 (EFZ) and 296.02→204.76 (I.S.). Samples were extracted using liquid-liquid extraction. The total run time was 2.0 min. The separation was achieved with HPLC-RP using a monolithic column. The assay was linear in the concentration range of 100 -5000 ng mL -1 . The mean recovery was 83%. Intra-and inter-day precision were < 9.5% and < 8.9%, respectively and accuracy was in the range ± 8.33%. The method was successfully applied to a bioequivalence study.

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Solid‐Phase Extraction and Clean‐Up Procedures in Pharmaceutical Analysis

Campíns‐Falcó

Herráez‐Hernández

Molíns-Legua

et al. 2022

Encyclopedia of Analytical Chemistry

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Solid‐phase extraction (SPE) using small cartridges filled with sorbents of a small particle size has rapidly established itself as an important sample clean‐up technique since the 1980s. It has prospered at the expense of traditional liquid–liquid extraction (LLE) which is considered labor‐intensive and frequently plagued by problems, such as emulsion formation and use of large volumes of hazardous solvents. A remarkable characteristic of SPE is its easy adaptation to on‐line mode by column switching techniques; switching can be affected manually or by automated controllers. The same analyte/sorbent interactions that are exploited in liquid chromatography (LC) are of use in SPE, but particle sizes employed are generally greater. Chemically bonded silica (SI), usually with C 18 and C 8 organic groups, is by far the most commonly used material. Cross‐linked polystyrene and other polymeric resins and mixed‐mode SPE sorbents are also widely used. Recently, different sorbents have been introduced in order to improve the selectivity such as molecularly imprinted polymers (MIPs) and immunoaffinity sorbents or to improve the extraction capacity through the increment of the surface‐to‐volume ratio (i.e. hypercross‐linked resins). Advances in material science in general and in nanomaterials in particular mark a trend in this field. Also, ionic liquids (ILs), carbon‐based materials, sol‐gel‐based compounds, and metal‐organic frameworks (MOFs), among others, are being introduced. Current trends in SPE are aimed toward the development of miniaturized systems which facilitate its automation and increase its precision, throughput, and cost‐effectiveness. Its compatibility with the goals of sustainable chemistry is remarkable. Examples of such trends are the new formats of SPE such as solid‐phase microextraction (SPME) including in‐tube solid‐phase microextraction (IT‐SPME) and tip‐based microextraction, between other formats. There are different approaches to automation for both off‐line and on‐line SPE, which involve different levels of apparatus cost. SPE is generally easier and cheaper than LLE for achieving this last goal. The precision obtained is similar for both techniques, while the recoveries obtained by SPE are generally better than those obtained by LLE. Enrichment, derivatization, and fractionation can also be carried out by use of SPE sorbents as supports.

show abstract

Simultaneous determination of fluoroquinolone, sulfonamide, and trimethoprim antibiotics in wastewater using tandem solid phase extraction and liquid chromatography–electrospray mass spectrometry

Cited by 323 publications

References 32 publications

An overview of analytical methodologies for the determination of antibiotics in environmental waters

An overview of analytical methodologies for the determination of antibiotics in environmental waters

A sensitive and robust lc-ms/ms method with monolithic column and electrospray ionization for the quantitation of efavirenz in human plasma: application to a bioequivalence study

Solid‐Phase Extraction and Clean‐Up Procedures in Pharmaceutical Analysis

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