Simultaneous determination of imipramine and amitryptiline by derivative spectrophotometry

Quantitative determination of captopril and prednisolone in tablets by FT-Raman spectroscopy

“…Several methods of captopril quantitative analysis in pharmaceutical preparations were reported. Among them quantification using iodometric titration [2], liquid chromatography (LC) [4], differential pulse polarography [5], flowinjection (FI) [6], chemiluminescence [7] also in connection with LC [8] or FI systems [9,10], fluorimetry [11], voltammetry [12], colorimetry and potentiometry [13] or biosensors [14] were described.…”

Argentimetric assay of captopril in bulk drug and in tablets

“…Methods based on derivative and difference ultraviolet spectrophotometry [17,18] have been employed but the techniques are of great utility for resolving mixtures than individual ingredients. Several other methods proposed for the determination of CPT include fluroimetry [19,20], coulometry [21], amperometry [22] and polarography [23,24], atomic absorption spectrometry [25], capillary isotachophoresis [26] and capillary electrophoresis [27,28].…”

Simultaneous colorimetric detection of four drugs in their pharmaceutical formulations using unmodified gold nanoparticles as a probe

“…Table 1 shows the analytical data of the present method for simultaneous colorimetric detection of four drugs using unmodied Au NPs as a probe. Compared with the performance of chromatographic [7][8][9][10][11][12][13][14] and spectrophotometric [16][17][18][19] methods for detection of four drugs, the present method demonstrated a lowered detection limit and a simplied procedure (without the any sample pretreatment at minimal volume of samples) (Table 2). Although LC-MS is an efficient tool for separation and determination of four drugs independently, the unmodied Au NPs-based colorimetric method is particularly attractive for simultaneous detection of four drugs because the color changes can be easily discerned with the naked-eye and then quantied by UV-visible spectrometry, which avoids tedious sample preparations and complicated instrumentation.…”

“…[1][2][3][4][5][6] Identication and quantication of four drugs (venlafaxine; imipramine; amlodipine; alfuzosin) require a simple, specic and sensitive method for routine analysis of individual drug in biological samples. So far, various analytical techniques including high performance liquid chromatography (HPLC), [7][8][9][10] liquid chromatography with mass spectrometry (LC-MS), 14 capillary electrophoresis, 15 uorescence 16 and UV-visible spectrometry [17][18][19] have been used for the analysis of four drugs independently in pharmaceutical and biological samples. However, some of these methods are expensive, somewhat time consuming, they require derivatization steps and expensive instruments, which makes it unavailable in many laboratories for the analysis of four drugs in biological samples.…”