Quantitative determination of captopril and prednisolone in tablets by FT-Raman spectroscopy

Mazurek, Sylwester; Szostak, Roman

doi:10.1016/j.jpba.2005.03.047

Cited by 99 publications

(54 citation statements)

References 23 publications

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“…It is a well known drug applied in the treatment of hypertension, coronary heart disease and congestive heart failure following myocardial infarction as well as in diabetic nephropathy. 1,2 Many analytical methods have been developed for CP determination, such as visual titrimetry, 3 electrometric methods, [4][5][6][7][8] capillary electrophoresis, 9 capillary isotachophoresis, 10 flow injection analysis, 11 and chromatographic methods. [12][13][14][15][16][17] The most widely used technique for captopril determination is high-performance liquid-chromatography.…”

Section: Introductionmentioning

confidence: 99%

“…Gas chromatographic methods reported for determining CP in dosage forms also involve derivatization besides being poorly sensitive. 17 Captopril has also been determined by spectrometric methods such as: FT-Raman spectroscopy, 2 fluorimetry, 18 atomic absorption spectrometry. 19 Numerous spectrophotometric methods have also been proposed for CP determination.…”

Section: Introductionmentioning

confidence: 99%

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Indirect spectrophotometric method for determination of captopril using Cr(VI) and diphenylcarbazide

Moldovan

Badea

Bunaciu³

et al. 2012

Quím. Nova

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Recebido em 21/9/11; aceito em 6/4/12, publicado na web em 3/7/12 A spectrophotometric method for the indirect determination of captopril (CP) in pharmaceutical formulations is proposed. The proposed procedure is based on the oxidation of captopril by potassium dichromate and the determination excess oxidant on the basis of its reaction with diphenylcarbazide (DPC). Under the optimum conditions, a good linear relationship (r = 0.9997) was obtained in the range of 0.08-3.5 μg mL -1. The assay limits of detection and quantitation were 0.024 and 0.08 μg mL -1 , respectively. The results obtained for captopril determination in pharmaceuticals using the proposed method and those obtained with the US Pharmacopoeia method were in good agreement at the 95% confidence level.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Indirect spectrophotometric method for determination of captopril using Cr(VI) and diphenylcarbazide

Moldovan

Badea

Bunaciu³

et al. 2012

Quím. Nova

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show abstract

“…Partial least squares discriminant analysis (PLS-DA) models based on Raman spectra were applied in the counterfeits test by de Peinder et al [18]. Besides, multivariate calibration methods have been applied to construct models for quantification of the active pharmaceutical ingredients (APIs) in tablets based on Raman spectra, such as partial least squares (PLS) [19][20][21][22], principal component regression (PCR) [23] and artificial neural networks (ANN) [24].…”

Section: Introductionmentioning

confidence: 99%

Classification and Quantitative Analysis of Azithromycin Tablets by Raman Spectroscopy and Chemometrics

Li¹,

Du²,

Cai³

et al. 2011

AJAC

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Raman spectroscopy has been proven a noninvasive technique with high potential in pharmaceutical industry. In this study, micro Raman technique and chemometric tools were used for identification of azithromycin (AZM) tablets by different manufacturers and quantitative analysis of the active pharmaceutical ingredient (API) in the samples. Support vector machine (SVM), Bayes classifier and K-nearest neighbour (KNN) were employed for identification, partial least squares (PLS) regression was used for quantitative determination, and interval partial least squares (iPLS) and Monte Carlo based uninformative variable elimination (MC-UVE) methods were used to select informative variables for improving the models. The results show that all the samples can be classified into groups by manufacturers with high accuracy, and the correlation coefficient between the predicted API concentrations and reference values is as high as 0.96. Therefore, micro Raman spectroscopy coupled with chemometrics may be a fast and powerful tool for identification and quantitative determination of pharmaceutical tablets.

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“…Therefore, measurements of glucocorticoids such as prednisolone and other natural and synthetic corticosteroids [7,8] with detection limits (LOD) around 1 mg L À1 in biological fluids have been extensively carried out and well established by using selective chromatographic techniques such as reversed-phase HPLC [9,10], liquid chromatography-ionspray mass spectrometry [11,12], micellar electrokinetic capillary chromatography coupled with solid phase extraction [13,14], GC-MS [15][16][17], LC-MS [18,19], LC-MS-MS [20,21] and FT-Raman spectroscopy [22] and fluorescence [23]. However, there are certain limitations in chromatographic and mass spectroscopic methods such as selecting suitable columns or mobile phase, finding a suitable reactant for postcolumn reaction in liquid chromatography, the need of toxic solvent, expensive instruments, and day to day maintenance.…”

Section: Introductionmentioning

confidence: 99%

Nanoscale Manipulation of Prednisolone as Electroactive Configuration Using Molecularly Imprinted‐Multiwalled Carbon Nanotube Paste Electrode

Rezaei

Mirahmadi-Zare

2011

Electroanalysis

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Prednisolone has no suitable configuration for electroactivation in the potential window from À1.2 to + 1.5 V. In this paper, a new catalytic application of molecularly imprinted polymers (MIP) was employed to achieve a suitable prednisolone conformation for electrochemical oxidation. Also, MIP as a recognition element improved the selectivity of the sensor for determination of prednisolone. In addition, to improve the sensitivity of the electrode multiwalled carbon nanotubes (MWCNT) were used in the preparation of MIP. Using differential pulse voltammetry (DPV) under optimized conditions, the calibration curve showed a linear dynamic range (0.08-160.00 mM) with a detection limit of 0.05 mM (S/N = 3). The modified electrode was successfully applied as prednisolone sensor in real samples such as plasma, urine and pharmaceutical formulation.

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Quantitative determination of captopril and prednisolone in tablets by FT-Raman spectroscopy

Cited by 99 publications

References 23 publications

Indirect spectrophotometric method for determination of captopril using Cr(VI) and diphenylcarbazide

Indirect spectrophotometric method for determination of captopril using Cr(VI) and diphenylcarbazide

Classification and Quantitative Analysis of Azithromycin Tablets by Raman Spectroscopy and Chemometrics

Nanoscale Manipulation of Prednisolone as Electroactive Configuration Using Molecularly Imprinted‐Multiwalled Carbon Nanotube Paste Electrode

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