2017
DOI: 10.1016/j.jchromb.2016.12.037
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Simultaneous determination of imperatorin and its metabolite xanthotoxol in rat plasma and urine by LC–MS/MS and its application to pharmacokinetic studies

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Cited by 12 publications
(6 citation statements)
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“…Furocoumarins inhibit the calcium channel, reduce platelet aggregation [ 9 ], induce apoptosis in human promyelocytic leukaemia [ 10 ] and show hepatoprotective effects [ 11 ]. Imperatorin has been reported to have numerous potent pharmacological actions, including anti-inflammation [ 12 ], anti-bacterial [ 13 ], anti-allergic [ 14 ], beneficial cardiovascular effects [ 15 , 16 , 17 ], neuromodulation [ 18 , 19 , 20 ] and is able to induce apoptosis in human promyelocytic leukaemia and HL-60 cells [ 10 ]. Effects of angelicin against postmenopausal osteoporosis were demonstrated [ 21 ].…”
Section: Introductionmentioning
confidence: 99%
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“…Furocoumarins inhibit the calcium channel, reduce platelet aggregation [ 9 ], induce apoptosis in human promyelocytic leukaemia [ 10 ] and show hepatoprotective effects [ 11 ]. Imperatorin has been reported to have numerous potent pharmacological actions, including anti-inflammation [ 12 ], anti-bacterial [ 13 ], anti-allergic [ 14 ], beneficial cardiovascular effects [ 15 , 16 , 17 ], neuromodulation [ 18 , 19 , 20 ] and is able to induce apoptosis in human promyelocytic leukaemia and HL-60 cells [ 10 ]. Effects of angelicin against postmenopausal osteoporosis were demonstrated [ 21 ].…”
Section: Introductionmentioning
confidence: 99%
“…However, in derived food or cosmetics products, viz. for target analysis in complex samples, more sensitive and selective methods are needed, mainly based on the use of tandem MS systems that allow to achieve low limits of quantification (LOQ) [ 1 , 2 , 20 , 52 , 53 , 54 , 55 ].…”
Section: Introductionmentioning
confidence: 99%
“…Until now, it is known that the prenyl group in the plant-derived polyphenolic compounds can undergo only hepatic phase I metabolism, which involves Cyt P-450 type enzymes. 15 Anaerobic gut metabolism of the prenyl functional group has never been reported. To our surprise, imperatorin (3, 23.8 min) and isoimperatorin (4, 28.6 min) were biotransformed by MRG-PMF1, and xanthotoxol (7, 8.6 min) and bergaptol (8, 9.9 min) were identified as metabolites, respectively (Figure 5).…”
Section: Resultsmentioning
confidence: 99%
“…Substrates 3 and 4 have a prenyl aryl ether functional group instead of a methyl aryl ether functional group as shown in Figures and . Until now, it is known that the prenyl group in the plant-derived polyphenolic compounds can undergo only hepatic phase I metabolism, which involves Cyt P-450 type enzymes . Anaerobic gut metabolism of the prenyl functional group has never been reported.…”
Section: Results and Discussionmentioning
confidence: 99%
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