Simultaneous determination of iodinated haloacetic acids and aromatic iodinated disinfection byproducts in waters with a new SPE-HPLC-MS/MS method

Hu, Shaoyang; Gong, Tingting; Ma, Jian; Tao, Yuxian; Xian, Qiming

doi:10.1016/j.chemosphere.2018.01.124

Cited by 53 publications

(26 citation statements)

References 34 publications

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“…This demonstrates the suitability of CE-MS for drinking water analysis applying efficient online preconcentration due to the low conductivity of such samples. With modern LC-MS and mixed-mode solid-phase extraction (SPE) preconcentration, Hu et al [19] showed a method for the quantitation especially for iodinated HAAs with LODs between 0.02 and 0.48 ng/L.…”

Section: Introductionmentioning

confidence: 99%

Enrichment-free analysis of anionic micropollutants in the sub-ppb range in drinking water by capillary electrophoresis-high resolution mass spectrometry

et al. 2020

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Reversed-phase liquid chromatography (RPLC) used for water analysis is not ideal for the analysis of highly polar and ionic contaminants because of low retention. Capillary electrophoresis (CE), on the other hand, is perfectly suited for the separation of ionic compounds but rarely applied in environmental analysis due to the weak concentration sensitivity when coupled to mass spectrometry (MS). However, novel interface designs and MS technology strongly improve the sensitivity. Here, a method is presented enabling the screening of anionic micropollutants in drinking water without sample pretreatment by coupling of CE to an Orbitrap mass spectrometer by a nanoflow sheath liquid interface. Targeted analysis of halogenated acetic acids, trifluoromethanesulfonic acid, and perfluorooctanoic and perfluorooctanesulfonic acid was conducted in drinking water samples which were chlorinated for disinfection. A bare fused silica capillary with an optimized background electrolyte (BGE) for separation consisting of 10% acetic acid with 10% isopropanol with large volume sample injection and optimized interface parameters offer limits of quantification in the range of < 0.1 to 0.5 μg/L with good linearity (R 2 > 0.993) and repeatability (14% standard deviation in area). Concentrations of the target analytes ranged from 0.1 to 6.2 μg/L in the water samples. Masses corresponding to halogenated methanesulfonic acids have been found as suspects and were subsequently verified by standards. Mono-, dichloro-, and bromochloro methanesulfonic acid were quantified in a range of 0.2 to 3.6 μg/L. Furthermore, five sulfonic acids, four organosulfates, and the artificial sweeteners acesulfame and cyclamate as well as inorganics such as halides, halogenates, phosphate, and sulfate could be determined as suspects among more than 300 features in a non-targeted screening. Overall, this approach demonstrates the great potential of CE-nanoESI-MS for the screening of ionic contaminants in environmental samples, complementary to chromatographic approaches.

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Section: Introductionmentioning

confidence: 99%

Enrichment-free analysis of anionic micropollutants in the sub-ppb range in drinking water by capillary electrophoresis-high resolution mass spectrometry

et al. 2020

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“…3, 18 and 21-23) or specific sorbent materials (e.g., anionic exchange resins) are required. 24 In either case, extraction protocols have to be exclusively and carefully developed to achieve acceptable performance levels. Several methodologies focused on the direct injection of the water sample into the analytical instrument have been also proposed to bypass the extraction step.…”

Section: Introductionmentioning

confidence: 99%

“…Chromatography has been achieved with ion exchange columns (ion chromatography, IC) [29][30][31][32] or reversed-phase columns (reversed-phase liquid chromatography, RPLC, or LC) packed with a silica-based sorbent modified to enhance the retention of polar analytes. 24,26,28,33,34 IC-MS/MS has been successfully used for the quantitative analysis of up to 13 HAAs and dalapon in water at levels in the low μg L −1 range (LOQs below 1 μg L −1 ). 29,32,35 The main concerns associated with the use of this technique for HAA analysis are, in addition to its high cost, the potential interferences of other anions commonly present in water matrices in the MS signal, and the complexity of the technique.…”

Section: Introductionmentioning

confidence: 99%

“…The use of LC-MS/MS to determine HAAs in water has gained attention in recent years. 24,26,33,36,37 This may be linked to advances in LC technology, that allowed the development of silica-based stationary phases with increased affinity for polar compounds (e.g., Luna C18 Polar from Phenomenex, 26 Acclaim HAAs from Thermo Fisher Scientific 33 or HSS T3 from Waters). 24,27 LC retention and separation of HAAs in the past, due to their high polar character, required the use of ion-pairing reagents in the mobile phase, specifically dibutylamine 38 or trimethylamine.…”

Section: Introductionmentioning

confidence: 99%

“…24,26,33,36,37 This may be linked to advances in LC technology, that allowed the development of silica-based stationary phases with increased affinity for polar compounds (e.g., Luna C18 Polar from Phenomenex, 26 Acclaim HAAs from Thermo Fisher Scientific 33 or HSS T3 from Waters). 24,27 LC retention and separation of HAAs in the past, due to their high polar character, required the use of ion-pairing reagents in the mobile phase, specifically dibutylamine 38 or trimethylamine. 39,40 Of all the LC-MS-based methodologies to determine HAAs in water reported in the literature, [24][25][26][27][28]33,34,36,37,41,42 none of them covers the whole suite of HAAs (13 chlorinated, brominated, and iodinated HAAs), and in some cases, details provided for method reproduction are scarce or method performance in real samples was poorly addressed.…”

Section: Introductionmentioning

confidence: 99%

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