Simultaneous determination of isoniazid and pyrazinamide in plasma by high performance liquid chromatography

Mahjoub, Abdallah A.; Khan, Amer Hayat; Sulaiman, Syed Azhar Syed; Lajis, Razak; Man, Che Nin; Ali, Irfhan A. Hyder

doi:10.4314/tjpr.v15i11.24

Cited by 7 publications

(4 citation statements)

References 15 publications

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“…INZ, also known as isonicotinylhydrazide, is an effective antibiotic for latent and active tuberculosis infections. Several classical analytical methods have been developed for its determination, including chemical and spectroscopic methods, such as titrimetry , spectrophotometry , high performance liquid chromatography (HPLC) and chemiluminescence , while electroanalytical techniques are of particular advantage, due to their practicality, simplicity, low‐cost, adequate sensitivity, precision and speediness for real‐time detection.…”

Section: Introductionmentioning

confidence: 99%

Silver Hexacyanoferrate (III) on a Hybrid Graphene Oxide/PAMAM Dendrimer Surface and Application as an Electrocatalyst in the Detection of Isoniazid

2018

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The polyamidoamine dendrimer PAMAM was covalently bound to graphene oxide via amide formation between any peripheral amine group dendrimer and the carboxyl groups present in graphene oxide. This material (GOP) was characterized by different spectroscopic techniques, namely Raman Spectroscopy, X‐Ray Photoelectron Spectroscopy (XPS), Fourier Transform Infrared Spectroscopy (FT‐IR) and X‐Ray Diffraction (XRD). The hybrid material was shown to adsorb silver, that in turn complexes with hexacyanoferrate (III) ions (GOPAgH). The complexed hybrid material was electrochemically investigated using cyclic voltammetry. Some electroanalytical parameters, such as different supporting electrolytes, the supporting electrolyte concentrations, hydrogen ion concentration effects and scan rate were evaluated in order to obtain optimum responses. The GOPAgH material was successfully tested in the electrocatalytic detection of Isoniazid using a graphite paste electrode with Limits of Detection and Quantification of 5.0×10−6 mol L−1 and 1.7×10−5 mol L−1, respectively.

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Section: Introductionmentioning

confidence: 99%

Silver Hexacyanoferrate (III) on a Hybrid Graphene Oxide/PAMAM Dendrimer Surface and Application as an Electrocatalyst in the Detection of Isoniazid

2018

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“…For some diseases (Huntington, Parkinson and Schizophrenia) the level of DA found in human bodily fluids is elevated, thus, DA is a vital diagnostic biomarker for these diseases [18]. Several methodologies have been applied in DA quantification including spectrometry [19], high performance liquid chromatography (HPLC) [20] and electroanalytical techniques [21], but electroanalytical ones are considered the most attractive because they relatively low-cost, rapid and sensitive [22]. There are no available publications concerning this hybrid material (citrate of β-cyclodextrin functionalized with PAMAM dendrimer doped with silver and iron) used as an electrochemical sensor for DOP detection and its application in synthetic urine samples.…”

Section: Introductionmentioning

confidence: 99%

β‐Cyclodextrin PAMAM Dendrimer Surface Doped with Silver and Hexacyanoferrate (III) and its Applications for Dopamine Detection in Synthetic Samples

et al. 2022

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A synthesis of β-cyclodextrin (β-Cd) functionalized with polyamide dendrimer PAMAM G.0 complexed with silver and potassium hexacyanoferrate (III) forming a mixed-valence complex (β-Cd-PAMAM-Ag/Fe) was proposed. This material was characterized by scanning electron microscopy (SEM), infrared spectroscopy (FT-IR), X-Ray diffraction (XRD), Energy Dispersion Spectroscopy (EDS) and Electron Paramagnetic Resonance (EPR). The hybrid complex was electrochemically investigated using cyclic voltammetry and some parameters (electrolyte, concentration of electrolyte, pH and scan rate) were evaluate in order to obtain optimum analytical responses. The β-Cd-PAMAM-Ag/Fe material was successfully applied in the electrocatalytic oxidation of dopamine (DOP) using Cyclic Voltammetry (CV) and Square Wave Voltammetry (SWV).

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“…Several methods for determination of one or more of the anti-TB drugs in plasma or serum are available [5][6]. Analysis of rifampicin in plasma and CSF has already been developed X The journal homepage www.jpacr.ub.ac.id p-ISSN : 2302 -4690 | e-ISSN : 2541 -0733 176 [7].…”

Section: Introductionmentioning

confidence: 99%

“…Poor patient results were related with short levels of INH or PZA. So individuation of INH and PZA portions supported on their blood concentration and CSF could be helpful ini optimizing the drug remedy for some patients with poor response [5].…”

Section: Introductionmentioning

confidence: 99%

Partial Validation of Ultra Performance Liquid Chromatography Method for Quantification of Isoniazid-Pyrazinamide in Human Samples

Yunivita

Meirina

Dewi

et al. 2021

J. Pure App. Chem Res

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Isoniazid (INH) and pyrazinamide (PZA) are first-line drugs in the treatment of meningitis of tuberculosis, in addition to rifampicin. The use of these drugs will determine the success of therapy to kill Mycobacterium tuberculosis in brain tissue that is difficult to penetrate by other drugs. Therefore, it is necessary to conduct research and monitor the use of this drug in plasma and cerebrospinal fluid (CSF) patients with TBM. This study aimed to determine the method of analysis of INH and PZA using Ultra Performance Liquid Chromatography Ultra Violet (UPLC-UV). The samples were taken from TBM patients who taken INH-PZA and others besides TBM patients who did not take INH-PZA. The analytic method carried out includes a comparison of the results of the analysis method for measuring levels of standard INH-PZA and INH-PZA in plasma and CSF samples. Analysis of INH-PZA in plasma and CSF can be performed using UPLC with UV detector, at least 100 uL plasma or CSF samples volume, with reproducible and accurate results.

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Simultaneous determination of isoniazid and pyrazinamide in plasma by high performance liquid chromatography

Cited by 7 publications

References 15 publications

Silver Hexacyanoferrate (III) on a Hybrid Graphene Oxide/PAMAM Dendrimer Surface and Application as an Electrocatalyst in the Detection of Isoniazid

Silver Hexacyanoferrate (III) on a Hybrid Graphene Oxide/PAMAM Dendrimer Surface and Application as an Electrocatalyst in the Detection of Isoniazid

β‐Cyclodextrin PAMAM Dendrimer Surface Doped with Silver and Hexacyanoferrate (III) and its Applications for Dopamine Detection in Synthetic Samples

Partial Validation of Ultra Performance Liquid Chromatography Method for Quantification of Isoniazid-Pyrazinamide in Human Samples

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