Simultaneous Determination of Isoproterenol, Acetaminophen and Folic Acid Using a Novel Nanostructure‐Based Electrochemical Sensor

Abstract

In this study, a carbon paste electrode modified with (E)‐2‐((2‐chlorophenylimino)methyl)benzene‐1,4‐diol (CD) and titanium dioxide nanoparticles (TiO2) was used to prepare a novel electrochemical sensor. The objective of this novel electrode modification was to seek new electrochemical performances for the detection of isoproterenol (IP) in the presence of acetaminophen (AC) and folic acid (FA). Initially, cyclic voltammetry (CV) was used to investigate the redox properties of this modified electrode at various scan rates. In the following, the mediated oxidation of IP at the modified electrode was described. The results showed an efficient catalytic activity of the electrode for the electrooxidation of IP, which leads to a reduction in its overpotential by more than 235 mV. The value of the electron transfer coefficient (α), catalytic rate constant (kh) and diffusion coefficient (D) were calculated for IP, using electrochemical approaches. Based on differential pulse voltammetry (DPV), the oxidation of IP exhibited a dynamic range between 0.5 and 1000 µM and a detection limit (3σ) of 0.47 µM. DPV was used for simultaneous determination of IP, AC and FA at the modified electrode. Finally, this method was used for the determination of IP in real samples, using standard addition method.

A Highly Sensitive Sensor Based on Reduced Graphene Oxide, Carbon Nanotube and a Co(II) Complex Modified Carbon Paste Electrode: Simultaneous Determination of Isoprenaline, Captopril and Tryptophan

“…The detection limit, linear rang and pH levels used in this study are comparable to other works in the literature 18, 40–42. Some of these works have some drawbacks such as high detection limits 18, 40, 42, small dynamic ranges 41 or high oxidation peak potentials 40, 42. In the present research, a combination of RGO, CNT and CBE has been used for detection of IP.…”

Online regeneration of a piezoelectric and impedimetric immunosensor for the detection of C-reactive protein on the oriented antibody gold surface

“…Electrochemical immunoassays have unique advantages such as high sensitivity, fast response time, portability, low cost, and ease of miniaturization. [23][24][25] Electrochemical impedance spectroscopy (EIS) is a powerful technique used for investigating affinity reactions such as protein-protein interactions. In the case of biosensing and affinity reactions based on antibody-antigen interactions on the electrode surface, EIS can be used to probe interfacial properties.…”

Different Electrocatalytic Response Related to the Morphological Structure of TiO2 Nanomaterial: Hydroquinone as an Analytical Probe

“…TiO 2 nanoparticles have super performance and broad applications as a photocatalyst and catalyst, in solar cells, gas sensors, pigments and other devices . Due to the great oxidizing power, high electro stability, redox selectivity and easy synthesis of TiO 2 , it is vastly used in electrocatalytic applications . The electrochemical behavior of TiO 2 depends on the crystal structure, surface properties and textural properties such as specific surface area, size, volume and distribution.…”